Microcalcification crystallography as a potential marker of DCIS recurrence
Abstract Ductal carcinoma in-situ (DCIS) accounts for 20–25% of all new breast cancer diagnoses. DCIS has an uncertain risk of progression to invasive breast cancer and a lack of predictive biomarkers may result in relatively high levels (~ 75%) of overtreatment. To identify unique prognostic biomar...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-06-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-33547-8 |
| _version_ | 1797806753564327936 |
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| author | Sarah B. Gosling Emily L. Arnold Samantha K. Davies Hannah Cross Ihssane Bouybayoune Doriana Calabrese Jayakrupakar Nallala Sarah E. Pinder Liping Fu Esther H. Lips Lorraine King Jeffrey Marks Allison Hall Lars J. Grimm Thomas Lynch Donna Pinto Hilary Stobart E. Shelley Hwang Jelle Wesseling Kalotina Geraki Nicholas Stone Iain D. Lyburn Charlene Greenwood Keith D. Rogers Grand Challenge PRECISION Consortium |
| author_facet | Sarah B. Gosling Emily L. Arnold Samantha K. Davies Hannah Cross Ihssane Bouybayoune Doriana Calabrese Jayakrupakar Nallala Sarah E. Pinder Liping Fu Esther H. Lips Lorraine King Jeffrey Marks Allison Hall Lars J. Grimm Thomas Lynch Donna Pinto Hilary Stobart E. Shelley Hwang Jelle Wesseling Kalotina Geraki Nicholas Stone Iain D. Lyburn Charlene Greenwood Keith D. Rogers Grand Challenge PRECISION Consortium |
| author_sort | Sarah B. Gosling |
| collection | DOAJ |
| description | Abstract Ductal carcinoma in-situ (DCIS) accounts for 20–25% of all new breast cancer diagnoses. DCIS has an uncertain risk of progression to invasive breast cancer and a lack of predictive biomarkers may result in relatively high levels (~ 75%) of overtreatment. To identify unique prognostic biomarkers of invasive progression, crystallographic and chemical features of DCIS microcalcifications have been explored. Samples from patients with at least 5-years of follow up and no known recurrence (174 calcifications in 67 patients) or ipsilateral invasive breast cancer recurrence (179 microcalcifications in 57 patients) were studied. Significant differences were noted between the two groups including whitlockite relative mass, hydroxyapatite and whitlockite crystal maturity and, elementally, sodium to calcium ion ratio. A preliminary predictive model for DCIS to invasive cancer progression was developed from these parameters with an AUC of 0.797. These results provide insights into the differing DCIS tissue microenvironments, and how these impact microcalcification formation. |
| first_indexed | 2024-03-13T06:12:06Z |
| format | Article |
| id | doaj.art-0c736cfe79ab4053ba3ef0858002ace5 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-13T06:12:06Z |
| publishDate | 2023-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-0c736cfe79ab4053ba3ef0858002ace52023-06-11T11:11:27ZengNature PortfolioScientific Reports2045-23222023-06-0113111010.1038/s41598-023-33547-8Microcalcification crystallography as a potential marker of DCIS recurrenceSarah B. Gosling0Emily L. Arnold1Samantha K. Davies2Hannah Cross3Ihssane Bouybayoune4Doriana Calabrese5Jayakrupakar Nallala6Sarah E. Pinder7Liping Fu8Esther H. Lips9Lorraine King10Jeffrey Marks11Allison Hall12Lars J. Grimm13Thomas Lynch14Donna Pinto15Hilary Stobart16E. Shelley Hwang17Jelle Wesseling18Kalotina Geraki19Nicholas Stone20Iain D. Lyburn21Charlene Greenwood22Keith D. Rogers23Grand Challenge PRECISION ConsortiumSchool of Chemical and Physical Sciences, Keele UniversityCranfield Forensic Institute, Cranfield UniversityCranfield Forensic Institute, Cranfield UniversitySchool of Chemical and Physical Sciences, Keele UniversitySchool of Cancer and Pharmaceutical Sciences, King’s College London, Guy’s HospitalSchool of Physics and Astronomy, University of ExeterSchool of Physics and Astronomy, University of ExeterSchool of Cancer and Pharmaceutical Sciences, King’s College London, Guy’s HospitalDivision of Molecular Pathology, The Netherlands Cancer InstituteDivision of Molecular Pathology, The Netherlands Cancer InstituteDepartment of Surgery, Duke University Medical CenterDepartment of Surgery, Duke University Medical CenterDepartment of Pathology, University of British ColombiaDepartment of Radiology, Duke UniversityDepartment of Surgery, Duke University Medical CenterDCIS411.comIndependent Cancer Patients’ VoiceDepartment of Surgery, Duke University Medical CenterDivision of Molecular Pathology, The Netherlands Cancer InstituteDiamond Light Source, Harwell Science and Innovation CampusSchool of Physics and Astronomy, University of ExeterCranfield Forensic Institute, Cranfield UniversitySchool of Chemical and Physical Sciences, Keele UniversityCranfield Forensic Institute, Cranfield UniversityAbstract Ductal carcinoma in-situ (DCIS) accounts for 20–25% of all new breast cancer diagnoses. DCIS has an uncertain risk of progression to invasive breast cancer and a lack of predictive biomarkers may result in relatively high levels (~ 75%) of overtreatment. To identify unique prognostic biomarkers of invasive progression, crystallographic and chemical features of DCIS microcalcifications have been explored. Samples from patients with at least 5-years of follow up and no known recurrence (174 calcifications in 67 patients) or ipsilateral invasive breast cancer recurrence (179 microcalcifications in 57 patients) were studied. Significant differences were noted between the two groups including whitlockite relative mass, hydroxyapatite and whitlockite crystal maturity and, elementally, sodium to calcium ion ratio. A preliminary predictive model for DCIS to invasive cancer progression was developed from these parameters with an AUC of 0.797. These results provide insights into the differing DCIS tissue microenvironments, and how these impact microcalcification formation.https://doi.org/10.1038/s41598-023-33547-8 |
| spellingShingle | Sarah B. Gosling Emily L. Arnold Samantha K. Davies Hannah Cross Ihssane Bouybayoune Doriana Calabrese Jayakrupakar Nallala Sarah E. Pinder Liping Fu Esther H. Lips Lorraine King Jeffrey Marks Allison Hall Lars J. Grimm Thomas Lynch Donna Pinto Hilary Stobart E. Shelley Hwang Jelle Wesseling Kalotina Geraki Nicholas Stone Iain D. Lyburn Charlene Greenwood Keith D. Rogers Grand Challenge PRECISION Consortium Microcalcification crystallography as a potential marker of DCIS recurrence Scientific Reports |
| title | Microcalcification crystallography as a potential marker of DCIS recurrence |
| title_full | Microcalcification crystallography as a potential marker of DCIS recurrence |
| title_fullStr | Microcalcification crystallography as a potential marker of DCIS recurrence |
| title_full_unstemmed | Microcalcification crystallography as a potential marker of DCIS recurrence |
| title_short | Microcalcification crystallography as a potential marker of DCIS recurrence |
| title_sort | microcalcification crystallography as a potential marker of dcis recurrence |
| url | https://doi.org/10.1038/s41598-023-33547-8 |
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