New Insights into Curcumin- and Resveratrol-Mediated Anti-Cancer Effects
Curcumin and resveratrol are bioactive natural compounds displaying anti-inflammatory, anti-oxidant and anti-cancer properties. In this study, we compared the cytotoxic effects of these molecules and the molecular mechanisms involved against Her-2/neu-positive breast and salivary cancer cell lines....
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/14/11/1068 |
| _version_ | 1797508840895283200 |
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| author | Andrea Arena Maria Anele Romeo Rossella Benedetti Laura Masuelli Roberto Bei Maria Saveria Gilardini Montani Mara Cirone |
| author_facet | Andrea Arena Maria Anele Romeo Rossella Benedetti Laura Masuelli Roberto Bei Maria Saveria Gilardini Montani Mara Cirone |
| author_sort | Andrea Arena |
| collection | DOAJ |
| description | Curcumin and resveratrol are bioactive natural compounds displaying anti-inflammatory, anti-oxidant and anti-cancer properties. In this study, we compared the cytotoxic effects of these molecules and the molecular mechanisms involved against Her-2/neu-positive breast and salivary cancer cell lines. We found that both curcumin and resveratrol were efficient in reducing cancer cell survival and that they differently affected autophagy, ROS and activation of the PI3K/AKT/mTOR pathway. Moreover, we found that resveratrol and curcumin in combination exerted a stronger cytotoxic effect in correlation with the induction of a stronger ER stress and the upregulation of pro-death UPR molecule CHOP. This effect also correlated with the induction of pro-survival autophagy by curcumin and its inhibition by resveratrol. In conclusion, this study unveils new molecular mechanisms underlying the anti-cancer effects of resveratrol, curcumin and their combination, which can help to design new therapeutic strategies based on the use of these polyphenols. |
| first_indexed | 2024-03-10T05:09:36Z |
| format | Article |
| id | doaj.art-0c73cea9daa048e6af05939c68194904 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T05:09:36Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-0c73cea9daa048e6af05939c681949042023-11-23T00:54:46ZengMDPI AGPharmaceuticals1424-82472021-10-011411106810.3390/ph14111068New Insights into Curcumin- and Resveratrol-Mediated Anti-Cancer EffectsAndrea Arena0Maria Anele Romeo1Rossella Benedetti2Laura Masuelli3Roberto Bei4Maria Saveria Gilardini Montani5Mara Cirone6Department of Experimental Medicine, “Sapienza” University of Rome, Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Viale Regina Elena 324, 00161 Rome, ItalyDepartment of Experimental Medicine, “Sapienza” University of Rome, Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Viale Regina Elena 324, 00161 Rome, ItalyDepartment of Experimental Medicine, “Sapienza” University of Rome, Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Viale Regina Elena 324, 00161 Rome, ItalyDepartment of Experimental Medicine, “Sapienza” University of Rome, Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Viale Regina Elena 324, 00161 Rome, ItalyDepartment of Clinical Science and Translational Medicine, “Tor Vergata” University of Rome, Via Montpellier 1, 00133 Rome, ItalyDepartment of Experimental Medicine, “Sapienza” University of Rome, Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Viale Regina Elena 324, 00161 Rome, ItalyDepartment of Experimental Medicine, “Sapienza” University of Rome, Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Viale Regina Elena 324, 00161 Rome, ItalyCurcumin and resveratrol are bioactive natural compounds displaying anti-inflammatory, anti-oxidant and anti-cancer properties. In this study, we compared the cytotoxic effects of these molecules and the molecular mechanisms involved against Her-2/neu-positive breast and salivary cancer cell lines. We found that both curcumin and resveratrol were efficient in reducing cancer cell survival and that they differently affected autophagy, ROS and activation of the PI3K/AKT/mTOR pathway. Moreover, we found that resveratrol and curcumin in combination exerted a stronger cytotoxic effect in correlation with the induction of a stronger ER stress and the upregulation of pro-death UPR molecule CHOP. This effect also correlated with the induction of pro-survival autophagy by curcumin and its inhibition by resveratrol. In conclusion, this study unveils new molecular mechanisms underlying the anti-cancer effects of resveratrol, curcumin and their combination, which can help to design new therapeutic strategies based on the use of these polyphenols.https://www.mdpi.com/1424-8247/14/11/1068Her-2/neu cancersresveratrolcurcuminER stressautophagyPI3K/AKT/mTOR |
| spellingShingle | Andrea Arena Maria Anele Romeo Rossella Benedetti Laura Masuelli Roberto Bei Maria Saveria Gilardini Montani Mara Cirone New Insights into Curcumin- and Resveratrol-Mediated Anti-Cancer Effects Pharmaceuticals Her-2/neu cancers resveratrol curcumin ER stress autophagy PI3K/AKT/mTOR |
| title | New Insights into Curcumin- and Resveratrol-Mediated Anti-Cancer Effects |
| title_full | New Insights into Curcumin- and Resveratrol-Mediated Anti-Cancer Effects |
| title_fullStr | New Insights into Curcumin- and Resveratrol-Mediated Anti-Cancer Effects |
| title_full_unstemmed | New Insights into Curcumin- and Resveratrol-Mediated Anti-Cancer Effects |
| title_short | New Insights into Curcumin- and Resveratrol-Mediated Anti-Cancer Effects |
| title_sort | new insights into curcumin and resveratrol mediated anti cancer effects |
| topic | Her-2/neu cancers resveratrol curcumin ER stress autophagy PI3K/AKT/mTOR |
| url | https://www.mdpi.com/1424-8247/14/11/1068 |
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