Adverse events of NOTES mediastinoscopy compared to conventional video-assisted mediastinoscopy: a randomized survival study in a porcine model
Background: Safety is a concern in natural orifice transluminal endoscopic surgery (NOTES) mediastinoscopy. The objective of this study was to compare the safety of NOTES mediastinoscopy with video-assisted mediastinoscopy (VAM). Methods: Twenty-four pigs were randomly assigned to NOTES o...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Georg Thieme Verlag KG
2015-08-01
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| Series: | Endoscopy International Open |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0034-1392599 |
| _version_ | 1828899661055787008 |
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| author | Henry Córdova Georgina Cubas Marc Boada Cristina Rodríguez de Miguel Graciela Martínez-Pallí Josep M. Gimferrer Gloria Fernández-Esparrach |
| author_facet | Henry Córdova Georgina Cubas Marc Boada Cristina Rodríguez de Miguel Graciela Martínez-Pallí Josep M. Gimferrer Gloria Fernández-Esparrach |
| author_sort | Henry Córdova |
| collection | DOAJ |
| description | Background: Safety is a concern in natural orifice transluminal endoscopic surgery (NOTES) mediastinoscopy. The objective of this study was to compare the safety of NOTES mediastinoscopy with video-assisted mediastinoscopy (VAM).
Methods: Twenty-four pigs were randomly assigned to NOTES or VAM. Thirty-minute mediastinoscopies were performed with the identification of seven predetermined structures. The animals were euthanized after 7 days and necropsy was performed.
Results: Mediastinoscopy was not possible in one animal in each group. There were more intraoperative adverse events with NOTES than VAM (7 vs. 2, P = 0.04); hemorrhage was the most frequent adverse event (4 and 1, respectively). At necropsy, pathological findings were observed in 13 animals (9 NOTES and 4 VAM; P = 0.03). Inflammatory parameters were not different between groups and were not related to adverse events.
Conclusion: Systematic NOTES mediastinoscopy is possible and comparable to VAM in terms of number of organs identified and inflammatory impact. However, the safety profile of NOTES mediastinoscopy has to be improved before it can be adopted in a clinical setting. |
| first_indexed | 2024-12-13T15:35:29Z |
| format | Article |
| id | doaj.art-0c741fbd4de94d2986a371e97305cc28 |
| institution | Directory Open Access Journal |
| issn | 2364-3722 2196-9736 |
| language | English |
| last_indexed | 2024-12-13T15:35:29Z |
| publishDate | 2015-08-01 |
| publisher | Georg Thieme Verlag KG |
| record_format | Article |
| series | Endoscopy International Open |
| spelling | doaj.art-0c741fbd4de94d2986a371e97305cc282022-12-21T23:40:03ZengGeorg Thieme Verlag KGEndoscopy International Open2364-37222196-97362015-08-010306E571E57610.1055/s-0034-1392599Adverse events of NOTES mediastinoscopy compared to conventional video-assisted mediastinoscopy: a randomized survival study in a porcine modelHenry Córdova0Georgina Cubas1Marc Boada2Cristina Rodríguez de Miguel3Graciela Martínez-Pallí4Josep M. Gimferrer5Gloria Fernández-Esparrach6Department of Gastroenterology, Hospital Clínic, University of Barcelona, Barcelona, SpainAnesthesiology Department, Hospital Clínic, University of Barcelona, Barcelona, SpainDepartment of Thoracic Surgery, Hospital Clínic, University of Barcelona, Barcelona, SpainDepartment of Gastroenterology, Hospital Clínic, University of Barcelona, Barcelona, SpainAnesthesiology Department, Hospital Clínic, University of Barcelona, Barcelona, SpainDepartment of Thoracic Surgery, Hospital Clínic, University of Barcelona, Barcelona, SpainDepartment of Gastroenterology, Hospital Clínic, University of Barcelona, Barcelona, SpainBackground: Safety is a concern in natural orifice transluminal endoscopic surgery (NOTES) mediastinoscopy. The objective of this study was to compare the safety of NOTES mediastinoscopy with video-assisted mediastinoscopy (VAM). Methods: Twenty-four pigs were randomly assigned to NOTES or VAM. Thirty-minute mediastinoscopies were performed with the identification of seven predetermined structures. The animals were euthanized after 7 days and necropsy was performed. Results: Mediastinoscopy was not possible in one animal in each group. There were more intraoperative adverse events with NOTES than VAM (7 vs. 2, P = 0.04); hemorrhage was the most frequent adverse event (4 and 1, respectively). At necropsy, pathological findings were observed in 13 animals (9 NOTES and 4 VAM; P = 0.03). Inflammatory parameters were not different between groups and were not related to adverse events. Conclusion: Systematic NOTES mediastinoscopy is possible and comparable to VAM in terms of number of organs identified and inflammatory impact. However, the safety profile of NOTES mediastinoscopy has to be improved before it can be adopted in a clinical setting.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0034-1392599 |
| spellingShingle | Henry Córdova Georgina Cubas Marc Boada Cristina Rodríguez de Miguel Graciela Martínez-Pallí Josep M. Gimferrer Gloria Fernández-Esparrach Adverse events of NOTES mediastinoscopy compared to conventional video-assisted mediastinoscopy: a randomized survival study in a porcine model Endoscopy International Open |
| title | Adverse events of NOTES mediastinoscopy compared to conventional video-assisted mediastinoscopy: a randomized survival study in a porcine model |
| title_full | Adverse events of NOTES mediastinoscopy compared to conventional video-assisted mediastinoscopy: a randomized survival study in a porcine model |
| title_fullStr | Adverse events of NOTES mediastinoscopy compared to conventional video-assisted mediastinoscopy: a randomized survival study in a porcine model |
| title_full_unstemmed | Adverse events of NOTES mediastinoscopy compared to conventional video-assisted mediastinoscopy: a randomized survival study in a porcine model |
| title_short | Adverse events of NOTES mediastinoscopy compared to conventional video-assisted mediastinoscopy: a randomized survival study in a porcine model |
| title_sort | adverse events of notes mediastinoscopy compared to conventional video assisted mediastinoscopy a randomized survival study in a porcine model |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0034-1392599 |
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