Radiotherapy may exacerbated anti‐programmed cell death 1 treatment induced vitiligo: A case report
Abstract Immunotherapy with programmed cell death 1 (PD‐1) checkpoint inhibitors combined with chemoradiotherapy shows great potential for cancer treatment and is getting extensively researched. However, a plethora of immune‐related adverse events (irAEs) has been observed during anti‐PD‐1 treatment...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-02-01
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| Series: | Skin Health and Disease |
| Online Access: | https://doi.org/10.1002/ski2.287 |
| _version_ | 1797336210496028672 |
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| author | Chengqian Chen Qihang Chang Bo Wang Yaqi Wang Zhen Zhang Xiuli Wang |
| author_facet | Chengqian Chen Qihang Chang Bo Wang Yaqi Wang Zhen Zhang Xiuli Wang |
| author_sort | Chengqian Chen |
| collection | DOAJ |
| description | Abstract Immunotherapy with programmed cell death 1 (PD‐1) checkpoint inhibitors combined with chemoradiotherapy shows great potential for cancer treatment and is getting extensively researched. However, a plethora of immune‐related adverse events (irAEs) has been observed during anti‐PD‐1 treatment, including cutaneous adverse events, such as vitiligo and pruritus. These adverse events may lead to treatment discontinuation. When anti‐PD‐1 treatment is combined with radiotherapy (RT), irAEs may be exacerbated. Here we present a case report of an elderly patient with stage IIIb rectal cancer, who developed PD‐1 inhibitor‐associated vitiligo. After a session of RT, vitiligo lesions enlarged shortly thereafter. After discontinuation of anti‐PD‐1 treatment, vitiligo lesions and pruritus quickly improved with appropriate treatment. The rectal cancer achieved clinical complete response with no sign of recurrence or metastasis during follow‐up. Considering the similar mechanism of anti‐PD‐1 treatment in targeting cancer and in inducing irAEs, cutaneous adverse events may be associated with favourable clinical response. Additionally, cutaneous irAEs aggravated by RT in this patient may suggested significant immune activation, which may occasionally contribute to tumour regression and favourable clinical outcome. |
| first_indexed | 2024-03-08T08:50:57Z |
| format | Article |
| id | doaj.art-0c743b0439f340f0811d597e53ad83bd |
| institution | Directory Open Access Journal |
| issn | 2690-442X |
| language | English |
| last_indexed | 2024-03-08T08:50:57Z |
| publishDate | 2024-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Skin Health and Disease |
| spelling | doaj.art-0c743b0439f340f0811d597e53ad83bd2024-02-01T09:32:21ZengWileySkin Health and Disease2690-442X2024-02-0141n/an/a10.1002/ski2.287Radiotherapy may exacerbated anti‐programmed cell death 1 treatment induced vitiligo: A case reportChengqian Chen0Qihang Chang1Bo Wang2Yaqi Wang3Zhen Zhang4Xiuli Wang5Institute of Photomedicine Shanghai Skin Disease Hospital School of Medicine Tongji University Shanghai ChinaInstitute of Photomedicine Shanghai Skin Disease Hospital School of Medicine Tongji University Shanghai ChinaDepartment of Dermatology University of Michigan Ann Arbor Michigan USADepartment of Radiation Oncology Fudan University Shanghai Cancer Center Shanghai ChinaDepartment of Radiation Oncology Fudan University Shanghai Cancer Center Shanghai ChinaInstitute of Photomedicine Shanghai Skin Disease Hospital School of Medicine Tongji University Shanghai ChinaAbstract Immunotherapy with programmed cell death 1 (PD‐1) checkpoint inhibitors combined with chemoradiotherapy shows great potential for cancer treatment and is getting extensively researched. However, a plethora of immune‐related adverse events (irAEs) has been observed during anti‐PD‐1 treatment, including cutaneous adverse events, such as vitiligo and pruritus. These adverse events may lead to treatment discontinuation. When anti‐PD‐1 treatment is combined with radiotherapy (RT), irAEs may be exacerbated. Here we present a case report of an elderly patient with stage IIIb rectal cancer, who developed PD‐1 inhibitor‐associated vitiligo. After a session of RT, vitiligo lesions enlarged shortly thereafter. After discontinuation of anti‐PD‐1 treatment, vitiligo lesions and pruritus quickly improved with appropriate treatment. The rectal cancer achieved clinical complete response with no sign of recurrence or metastasis during follow‐up. Considering the similar mechanism of anti‐PD‐1 treatment in targeting cancer and in inducing irAEs, cutaneous adverse events may be associated with favourable clinical response. Additionally, cutaneous irAEs aggravated by RT in this patient may suggested significant immune activation, which may occasionally contribute to tumour regression and favourable clinical outcome.https://doi.org/10.1002/ski2.287 |
| spellingShingle | Chengqian Chen Qihang Chang Bo Wang Yaqi Wang Zhen Zhang Xiuli Wang Radiotherapy may exacerbated anti‐programmed cell death 1 treatment induced vitiligo: A case report Skin Health and Disease |
| title | Radiotherapy may exacerbated anti‐programmed cell death 1 treatment induced vitiligo: A case report |
| title_full | Radiotherapy may exacerbated anti‐programmed cell death 1 treatment induced vitiligo: A case report |
| title_fullStr | Radiotherapy may exacerbated anti‐programmed cell death 1 treatment induced vitiligo: A case report |
| title_full_unstemmed | Radiotherapy may exacerbated anti‐programmed cell death 1 treatment induced vitiligo: A case report |
| title_short | Radiotherapy may exacerbated anti‐programmed cell death 1 treatment induced vitiligo: A case report |
| title_sort | radiotherapy may exacerbated anti programmed cell death 1 treatment induced vitiligo a case report |
| url | https://doi.org/10.1002/ski2.287 |
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