Chinese Herbal Medicine for Mild Cognitive Impairment: A Systematic Review of Randomized Controlled Trials
ObjectivesThis study aims to explore the benefits and harms of Chinese Herbal Medicine (CHM) for mild cognitive impairment (MCI).MethodsElectronic searching was conducted in two English and four Chinese databases till 2021 December. Randomized clinical trials on CHM compared to no intervention, plac...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-06-01
|
| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.903224/full |
| _version_ | 1828805120247201792 |
|---|---|
| author | Ning Liang Yaxin Chen Sihong Yang Changhao Liang Lidong Gao Shang Wang Yanping Wang Zhanjun Zhang Nannan Shi Nannan Shi |
| author_facet | Ning Liang Yaxin Chen Sihong Yang Changhao Liang Lidong Gao Shang Wang Yanping Wang Zhanjun Zhang Nannan Shi Nannan Shi |
| author_sort | Ning Liang |
| collection | DOAJ |
| description | ObjectivesThis study aims to explore the benefits and harms of Chinese Herbal Medicine (CHM) for mild cognitive impairment (MCI).MethodsElectronic searching was conducted in two English and four Chinese databases till 2021 December. Randomized clinical trials on CHM compared to no intervention, placebo or other therapies for MCI were included.ResultsForty-nine RCTs (48 finished trials and 1 protocol) were identified. The overall methodological quality of included trials was relatively low. This review found that compared to no intervention or placebo, CHM can significantly decrease the number of patients who progressed to dementia (RR 0.36, 95% CI 0.22–0.58) and increase the cognitive function assessed by MMSE (MD 1.96, 95% CI 1.41–2.50) and MoCA (MD 2.44, 95% CI 1.57–3.31). The subgroup analysis of different CHM showed that Ginko leaf tablets can significantly improve the cognitive function compared to no intervention or placebo when assessed by MMSE (MD 2.03, 95% CI 1.18–2.88) and MoCA (MD 3.11, 95% CI 1.90–4.33). Compared to western medicine, CHM can significantly increase the score of MMSE (MD 0.88 95% CI 0.46–1.30) and MoCA (MD 0.87, 95% CI 0.33–1.41), but there was no significant difference on the score of ADL (SMD −0.61, 95% CI −1.49 to 0.27). None of the RCTs reported on the quality of life. Of 22 RCTs that reported adverse events, there was no statistical difference between the CHM and the control group.ConclusionsCHM, Ginko leaf extracts in particular, could help to prevent progression into dementia and to improve cognitive function and ability of daily living activities. More qualified RCTs were needed to confirm the conclusion due to the low quality of current trials.Systematic Review RegistrationUnique Identifier: CRD42020157148. |
| first_indexed | 2024-12-12T07:50:07Z |
| format | Article |
| id | doaj.art-0c78aa6eb81542f8ba3bbd2d69f68a7e |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-12T07:50:07Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-0c78aa6eb81542f8ba3bbd2d69f68a7e2022-12-22T00:32:27ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-06-011310.3389/fneur.2022.903224903224Chinese Herbal Medicine for Mild Cognitive Impairment: A Systematic Review of Randomized Controlled TrialsNing Liang0Yaxin Chen1Sihong Yang2Changhao Liang3Lidong Gao4Shang Wang5Yanping Wang6Zhanjun Zhang7Nannan Shi8Nannan Shi9Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, ChinaInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, ChinaInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, ChinaCenter for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, ChinaCollege of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaCollege of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, ChinaState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, ChinaInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, ChinaState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, ChinaObjectivesThis study aims to explore the benefits and harms of Chinese Herbal Medicine (CHM) for mild cognitive impairment (MCI).MethodsElectronic searching was conducted in two English and four Chinese databases till 2021 December. Randomized clinical trials on CHM compared to no intervention, placebo or other therapies for MCI were included.ResultsForty-nine RCTs (48 finished trials and 1 protocol) were identified. The overall methodological quality of included trials was relatively low. This review found that compared to no intervention or placebo, CHM can significantly decrease the number of patients who progressed to dementia (RR 0.36, 95% CI 0.22–0.58) and increase the cognitive function assessed by MMSE (MD 1.96, 95% CI 1.41–2.50) and MoCA (MD 2.44, 95% CI 1.57–3.31). The subgroup analysis of different CHM showed that Ginko leaf tablets can significantly improve the cognitive function compared to no intervention or placebo when assessed by MMSE (MD 2.03, 95% CI 1.18–2.88) and MoCA (MD 3.11, 95% CI 1.90–4.33). Compared to western medicine, CHM can significantly increase the score of MMSE (MD 0.88 95% CI 0.46–1.30) and MoCA (MD 0.87, 95% CI 0.33–1.41), but there was no significant difference on the score of ADL (SMD −0.61, 95% CI −1.49 to 0.27). None of the RCTs reported on the quality of life. Of 22 RCTs that reported adverse events, there was no statistical difference between the CHM and the control group.ConclusionsCHM, Ginko leaf extracts in particular, could help to prevent progression into dementia and to improve cognitive function and ability of daily living activities. More qualified RCTs were needed to confirm the conclusion due to the low quality of current trials.Systematic Review RegistrationUnique Identifier: CRD42020157148.https://www.frontiersin.org/articles/10.3389/fneur.2022.903224/fullmild cognitive impairment (MCI)Chinese herbal medicinesystematic reviewmeta-analysistraditional Chinese medicine |
| spellingShingle | Ning Liang Yaxin Chen Sihong Yang Changhao Liang Lidong Gao Shang Wang Yanping Wang Zhanjun Zhang Nannan Shi Nannan Shi Chinese Herbal Medicine for Mild Cognitive Impairment: A Systematic Review of Randomized Controlled Trials Frontiers in Neurology mild cognitive impairment (MCI) Chinese herbal medicine systematic review meta-analysis traditional Chinese medicine |
| title | Chinese Herbal Medicine for Mild Cognitive Impairment: A Systematic Review of Randomized Controlled Trials |
| title_full | Chinese Herbal Medicine for Mild Cognitive Impairment: A Systematic Review of Randomized Controlled Trials |
| title_fullStr | Chinese Herbal Medicine for Mild Cognitive Impairment: A Systematic Review of Randomized Controlled Trials |
| title_full_unstemmed | Chinese Herbal Medicine for Mild Cognitive Impairment: A Systematic Review of Randomized Controlled Trials |
| title_short | Chinese Herbal Medicine for Mild Cognitive Impairment: A Systematic Review of Randomized Controlled Trials |
| title_sort | chinese herbal medicine for mild cognitive impairment a systematic review of randomized controlled trials |
| topic | mild cognitive impairment (MCI) Chinese herbal medicine systematic review meta-analysis traditional Chinese medicine |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.903224/full |
| work_keys_str_mv | AT ningliang chineseherbalmedicineformildcognitiveimpairmentasystematicreviewofrandomizedcontrolledtrials AT yaxinchen chineseherbalmedicineformildcognitiveimpairmentasystematicreviewofrandomizedcontrolledtrials AT sihongyang chineseherbalmedicineformildcognitiveimpairmentasystematicreviewofrandomizedcontrolledtrials AT changhaoliang chineseherbalmedicineformildcognitiveimpairmentasystematicreviewofrandomizedcontrolledtrials AT lidonggao chineseherbalmedicineformildcognitiveimpairmentasystematicreviewofrandomizedcontrolledtrials AT shangwang chineseherbalmedicineformildcognitiveimpairmentasystematicreviewofrandomizedcontrolledtrials AT yanpingwang chineseherbalmedicineformildcognitiveimpairmentasystematicreviewofrandomizedcontrolledtrials AT zhanjunzhang chineseherbalmedicineformildcognitiveimpairmentasystematicreviewofrandomizedcontrolledtrials AT nannanshi chineseherbalmedicineformildcognitiveimpairmentasystematicreviewofrandomizedcontrolledtrials AT nannanshi chineseherbalmedicineformildcognitiveimpairmentasystematicreviewofrandomizedcontrolledtrials |