Immune surveillance and humoral immune responses in kidney transplantation – A look back at T follicular helper cells
T follicular helper cells comprise a specialized, heterogeneous subset of immune-competent T helper cells capable of influencing B cell responses in lymphoid tissues. In physiology, for example in response to microbial challenges or vaccination, this interaction chiefly results in the production of...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1114842/full |
| _version_ | 1827902952127332352 |
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| author | Julien Subburayalu Julien Subburayalu Julien Subburayalu |
| author_facet | Julien Subburayalu Julien Subburayalu Julien Subburayalu |
| author_sort | Julien Subburayalu |
| collection | DOAJ |
| description | T follicular helper cells comprise a specialized, heterogeneous subset of immune-competent T helper cells capable of influencing B cell responses in lymphoid tissues. In physiology, for example in response to microbial challenges or vaccination, this interaction chiefly results in the production of protecting antibodies and humoral memory. In the context of kidney transplantation, however, immune surveillance provided by T follicular helper cells can take a life of its own despite matching of human leukocyte antigens and employing the latest immunosuppressive regiments. This puts kidney transplant recipients at risk of subclinical and clinical rejection episodes with a potential risk for allograft loss. In this review, the current understanding of immune surveillance provided by T follicular helper cells is briefly described in physiological responses to contrast those pathological responses observed after kidney transplantation. Sensitization of T follicular helper cells with the subsequent emergence of detectable donor-specific human leukocyte antigen antibodies, non-human leukocyte antigen antibodies their implication for kidney transplantation and lessons learnt from other transplantation “settings” with special attention to antibody-mediated rejection will be addressed. |
| first_indexed | 2024-03-13T00:07:23Z |
| format | Article |
| id | doaj.art-0c78b384895d4cd397c0e007449351d0 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-13T00:07:23Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-0c78b384895d4cd397c0e007449351d02023-07-12T21:14:04ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-07-011410.3389/fimmu.2023.11148421114842Immune surveillance and humoral immune responses in kidney transplantation – A look back at T follicular helper cellsJulien Subburayalu0Julien Subburayalu1Julien Subburayalu2Department of Internal Medicine I, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, GermanyCenter for Regenerative Therapies (CRTD), Technische Universität Dresden, Dresden, GermanyDepartment of Medicine, University of Cambridge, Cambridge, United KingdomT follicular helper cells comprise a specialized, heterogeneous subset of immune-competent T helper cells capable of influencing B cell responses in lymphoid tissues. In physiology, for example in response to microbial challenges or vaccination, this interaction chiefly results in the production of protecting antibodies and humoral memory. In the context of kidney transplantation, however, immune surveillance provided by T follicular helper cells can take a life of its own despite matching of human leukocyte antigens and employing the latest immunosuppressive regiments. This puts kidney transplant recipients at risk of subclinical and clinical rejection episodes with a potential risk for allograft loss. In this review, the current understanding of immune surveillance provided by T follicular helper cells is briefly described in physiological responses to contrast those pathological responses observed after kidney transplantation. Sensitization of T follicular helper cells with the subsequent emergence of detectable donor-specific human leukocyte antigen antibodies, non-human leukocyte antigen antibodies their implication for kidney transplantation and lessons learnt from other transplantation “settings” with special attention to antibody-mediated rejection will be addressed.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1114842/fullHLA antigensT follicular helper celltransplantation immunologysolid organ transplantation, kidney transplantationdonor-specific HLA antibodynon-HLA antibody |
| spellingShingle | Julien Subburayalu Julien Subburayalu Julien Subburayalu Immune surveillance and humoral immune responses in kidney transplantation – A look back at T follicular helper cells Frontiers in Immunology HLA antigens T follicular helper cell transplantation immunology solid organ transplantation, kidney transplantation donor-specific HLA antibody non-HLA antibody |
| title | Immune surveillance and humoral immune responses in kidney transplantation – A look back at T follicular helper cells |
| title_full | Immune surveillance and humoral immune responses in kidney transplantation – A look back at T follicular helper cells |
| title_fullStr | Immune surveillance and humoral immune responses in kidney transplantation – A look back at T follicular helper cells |
| title_full_unstemmed | Immune surveillance and humoral immune responses in kidney transplantation – A look back at T follicular helper cells |
| title_short | Immune surveillance and humoral immune responses in kidney transplantation – A look back at T follicular helper cells |
| title_sort | immune surveillance and humoral immune responses in kidney transplantation a look back at t follicular helper cells |
| topic | HLA antigens T follicular helper cell transplantation immunology solid organ transplantation, kidney transplantation donor-specific HLA antibody non-HLA antibody |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1114842/full |
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