Antioxidant and Anti-Inflammatory Phytochemicals for the Treatment of Inflammatory Bowel Disease: A Systematic Review
Inflammatory bowel disease (IBD) remains a burden for patients with increasing prevalence in industrialized countries. Phytochemicals are non-nutrient plant derived bioactive substances with antioxidant and anti-inflammatory effects that may prove beneficial to IBD patients. This review aims to over...
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MDPI AG
2024-03-01
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| Online Access: | https://www.mdpi.com/2076-3417/14/5/2177 |
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| author | George Pantalos Natalia Vaou Smaragda Papachristidou Elisavet Stavropoulou Christina Tsigalou Chrysa Voidarou Eugenia Bezirtzoglou |
| author_facet | George Pantalos Natalia Vaou Smaragda Papachristidou Elisavet Stavropoulou Christina Tsigalou Chrysa Voidarou Eugenia Bezirtzoglou |
| author_sort | George Pantalos |
| collection | DOAJ |
| description | Inflammatory bowel disease (IBD) remains a burden for patients with increasing prevalence in industrialized countries. Phytochemicals are non-nutrient plant derived bioactive substances with antioxidant and anti-inflammatory effects that may prove beneficial to IBD patients. This review aims to overview current evidence on the application and impact of isolated phytochemicals or phytochemicals contained in plant extracts and essential oils on patients suffering from IBD. A systematic literature search was conducted for studies relating to the use of phytochemicals for the treatment of IBD. Ultimately, 37 human clinical trials and 3 systematic reviews providing human IBD patient data relevant to phytochemicals as therapeutic agents were included. Phytochemicals in the form of curcumin, <i>Plantago ovata</i> seeds, polyphenon E, silymarin, resveratrol supplements or an herbal preparation of myrrh, chamomile and coffee charcoal have evidence from human clinical trials supporting their safety and beneficial effects. Cannabinoids improve quality of life but not IBD outcomes. The addition of probiotics like <i>B. longum</i> to fructo-oligosaccharides promote healthy composition of the gut microbiome. Phytochemicals like mastiha, anthocyanins, berberine, tormentil, T2, ecabet sodium and Pycnogenol need more well-designed trials. Systematic research on phytochemicals can lead to the discovery of useful therapeutics. These secondary metabolites can be incorporated in current IBD treatment strategies to limit side effects, promote mucosal healing and provide higher quality of life to patients. |
| first_indexed | 2024-04-25T00:34:00Z |
| format | Article |
| id | doaj.art-0c797fec1dc044b0899fa1e0226c68b5 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-04-25T00:34:00Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-0c797fec1dc044b0899fa1e0226c68b52024-03-12T16:40:23ZengMDPI AGApplied Sciences2076-34172024-03-01145217710.3390/app14052177Antioxidant and Anti-Inflammatory Phytochemicals for the Treatment of Inflammatory Bowel Disease: A Systematic ReviewGeorge Pantalos0Natalia Vaou1Smaragda Papachristidou2Elisavet Stavropoulou3Christina Tsigalou4Chrysa Voidarou5Eugenia Bezirtzoglou6Pediatric Surgery Department, Penteli General Children’s Hospital, 15236 Athens, GreeceLaboratory of Hygiene and Environmental Protection, Department of Medicine, Democritus University of Thrace, Dragana, 68100 Alexandroupolis, GreeceSecond Department of Pediatrics, School of Medicine, National and Kapodistrian University of Athens, P.&A. Kyriakou Children’s Hospital, 11527 Athens, GreeceLaboratory of Hygiene and Environmental Protection, Department of Medicine, Democritus University of Thrace, Dragana, 68100 Alexandroupolis, GreeceLaboratory of Hygiene and Environmental Protection, Department of Medicine, Democritus University of Thrace, Dragana, 68100 Alexandroupolis, GreeceDepartment of Agriculture, School of Agriculture, University of Ioannina, 47100 Arta, GreeceLaboratory of Hygiene and Environmental Protection, Department of Medicine, Democritus University of Thrace, Dragana, 68100 Alexandroupolis, GreeceInflammatory bowel disease (IBD) remains a burden for patients with increasing prevalence in industrialized countries. Phytochemicals are non-nutrient plant derived bioactive substances with antioxidant and anti-inflammatory effects that may prove beneficial to IBD patients. This review aims to overview current evidence on the application and impact of isolated phytochemicals or phytochemicals contained in plant extracts and essential oils on patients suffering from IBD. A systematic literature search was conducted for studies relating to the use of phytochemicals for the treatment of IBD. Ultimately, 37 human clinical trials and 3 systematic reviews providing human IBD patient data relevant to phytochemicals as therapeutic agents were included. Phytochemicals in the form of curcumin, <i>Plantago ovata</i> seeds, polyphenon E, silymarin, resveratrol supplements or an herbal preparation of myrrh, chamomile and coffee charcoal have evidence from human clinical trials supporting their safety and beneficial effects. Cannabinoids improve quality of life but not IBD outcomes. The addition of probiotics like <i>B. longum</i> to fructo-oligosaccharides promote healthy composition of the gut microbiome. Phytochemicals like mastiha, anthocyanins, berberine, tormentil, T2, ecabet sodium and Pycnogenol need more well-designed trials. Systematic research on phytochemicals can lead to the discovery of useful therapeutics. These secondary metabolites can be incorporated in current IBD treatment strategies to limit side effects, promote mucosal healing and provide higher quality of life to patients.https://www.mdpi.com/2076-3417/14/5/2177phytochemicalinflammatory bowel diseaseclinical studypreventiontreatmentantioxidant |
| spellingShingle | George Pantalos Natalia Vaou Smaragda Papachristidou Elisavet Stavropoulou Christina Tsigalou Chrysa Voidarou Eugenia Bezirtzoglou Antioxidant and Anti-Inflammatory Phytochemicals for the Treatment of Inflammatory Bowel Disease: A Systematic Review Applied Sciences phytochemical inflammatory bowel disease clinical study prevention treatment antioxidant |
| title | Antioxidant and Anti-Inflammatory Phytochemicals for the Treatment of Inflammatory Bowel Disease: A Systematic Review |
| title_full | Antioxidant and Anti-Inflammatory Phytochemicals for the Treatment of Inflammatory Bowel Disease: A Systematic Review |
| title_fullStr | Antioxidant and Anti-Inflammatory Phytochemicals for the Treatment of Inflammatory Bowel Disease: A Systematic Review |
| title_full_unstemmed | Antioxidant and Anti-Inflammatory Phytochemicals for the Treatment of Inflammatory Bowel Disease: A Systematic Review |
| title_short | Antioxidant and Anti-Inflammatory Phytochemicals for the Treatment of Inflammatory Bowel Disease: A Systematic Review |
| title_sort | antioxidant and anti inflammatory phytochemicals for the treatment of inflammatory bowel disease a systematic review |
| topic | phytochemical inflammatory bowel disease clinical study prevention treatment antioxidant |
| url | https://www.mdpi.com/2076-3417/14/5/2177 |
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