A case of a Young Multiple Myeloma Patient With Poor Prognostic Cytogenetics
Multiple myeloma is a hematologic malignancy and a subtype of plasma cell dyscrasias, which accounts for 13% of all hematologic malignancies. It mainly affects older adults and is diagnosed in only 2% of the young population under the age of 40 years. This report presents a 33-year-old man diagnosed...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2023-02-01
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| Series: | Clinical Medicine Insights: Case Reports |
| Online Access: | https://doi.org/10.1177/11795476231157245 |
| _version_ | 1797903425812299776 |
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| author | Effat Iranijam Somaieh Matin Mohammad Negaresh |
| author_facet | Effat Iranijam Somaieh Matin Mohammad Negaresh |
| author_sort | Effat Iranijam |
| collection | DOAJ |
| description | Multiple myeloma is a hematologic malignancy and a subtype of plasma cell dyscrasias, which accounts for 13% of all hematologic malignancies. It mainly affects older adults and is diagnosed in only 2% of the young population under the age of 40 years. This report presents a 33-year-old man diagnosed with Multiple myeloma with 4 poor prognostic specifications consisting of amplification of the 1q21, Translocation of t(4;14), deletion of the 6q21 and 13q14, along with decreased chromosome count to 44, X,-Y. Even though the combination of 4 poor prognostic cytogenetics in young patients is rare, he responded significantly to the Bortezomib regimen. He was selected as a candidate for bone marrow transplantation. The treatments get interrupted 2 days after the first session of the fifth cycle due to an undesirable COVID-19 infection. After 20 days, the symptoms return, and paraclinical findings show signs of MM relapse. |
| first_indexed | 2024-04-10T09:32:44Z |
| format | Article |
| id | doaj.art-0c79bf25992d4737acbf3a173f726b43 |
| institution | Directory Open Access Journal |
| issn | 1179-5476 |
| language | English |
| last_indexed | 2024-04-10T09:32:44Z |
| publishDate | 2023-02-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Clinical Medicine Insights: Case Reports |
| spelling | doaj.art-0c79bf25992d4737acbf3a173f726b432023-02-18T15:33:27ZengSAGE PublishingClinical Medicine Insights: Case Reports1179-54762023-02-011610.1177/11795476231157245A case of a Young Multiple Myeloma Patient With Poor Prognostic CytogeneticsEffat Iranijam0Somaieh Matin1Mohammad Negaresh2Department of Internal Medicine (Hematology division), Ardabil University of Medical Sciences, Ardabil, IranDepartment of Internal Medicine (Gastroenterology division), Ardabil University of Medical Sciences, Ardabil, IranDepartment of Internal Medicine, Ardabil University of Medical Sciences, Ardabil, IranMultiple myeloma is a hematologic malignancy and a subtype of plasma cell dyscrasias, which accounts for 13% of all hematologic malignancies. It mainly affects older adults and is diagnosed in only 2% of the young population under the age of 40 years. This report presents a 33-year-old man diagnosed with Multiple myeloma with 4 poor prognostic specifications consisting of amplification of the 1q21, Translocation of t(4;14), deletion of the 6q21 and 13q14, along with decreased chromosome count to 44, X,-Y. Even though the combination of 4 poor prognostic cytogenetics in young patients is rare, he responded significantly to the Bortezomib regimen. He was selected as a candidate for bone marrow transplantation. The treatments get interrupted 2 days after the first session of the fifth cycle due to an undesirable COVID-19 infection. After 20 days, the symptoms return, and paraclinical findings show signs of MM relapse.https://doi.org/10.1177/11795476231157245 |
| spellingShingle | Effat Iranijam Somaieh Matin Mohammad Negaresh A case of a Young Multiple Myeloma Patient With Poor Prognostic Cytogenetics Clinical Medicine Insights: Case Reports |
| title | A case of a Young Multiple Myeloma Patient With Poor Prognostic Cytogenetics |
| title_full | A case of a Young Multiple Myeloma Patient With Poor Prognostic Cytogenetics |
| title_fullStr | A case of a Young Multiple Myeloma Patient With Poor Prognostic Cytogenetics |
| title_full_unstemmed | A case of a Young Multiple Myeloma Patient With Poor Prognostic Cytogenetics |
| title_short | A case of a Young Multiple Myeloma Patient With Poor Prognostic Cytogenetics |
| title_sort | case of a young multiple myeloma patient with poor prognostic cytogenetics |
| url | https://doi.org/10.1177/11795476231157245 |
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