Effective Amelioration of Liver Fibrosis Through Lentiviral Vector Carrying Toxoplasma gondii gra15II in Murine Model

Effective Amelioration of Liver Fibrosis Through Lentiviral Vector Carrying Toxoplasma gondii gra15II in Murine Model

Our previous investigations indicated that in vitro polarization of mouse macrophages by Toxoplasma gondii type II strain dense granule protein 15 (GRA15II), one of the genotype-associated effectors of T. gondii, induced the phenotypes of classically activated macrophage (M1). Transfusion of the cel...

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Bibliographic Details
Main Authors: Lei Liu, Mengmeng Jin, Qing Tao, Li Yu, Jian Du, Cong Wang, Qingli Luo, Tian Xing, Yuanhong Xu, Jilong Shen, Deyong Chu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Immunology
Subjects:
GRA15
lentiviral vector
schistosomiasis hepatic fibrosis
gene delivery
macrophage
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01572/full

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