Kinetic analysis of the growth rate of sporadic and hereditary medullary thyroid carcinoma: comparing the postoperative calcitonin-doubling rate with the hypothetical preoperative tumor volume-doubling rate
Abstract Background Our previous kinetic analyses of changes in the tumor volume (TV) of papillary thyroid microcarcinomas during active surveillance revealed that the tumors’ growth varied over time from rather rapid growth to shrinkage and that the hypothetical TV-doubling rates (DRs) before the p...
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| Format: | Article |
| Language: | English |
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BMC
2020-07-01
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| Series: | Thyroid Research |
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| Online Access: | http://link.springer.com/article/10.1186/s13044-020-00087-6 |
| _version_ | 1819147007965528064 |
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| author | Minoru Kihara Akira Miyauchi Hiroo Masuoka Takuya Higashiyama Yasuhiro Ito Akihiro Miya |
| author_facet | Minoru Kihara Akira Miyauchi Hiroo Masuoka Takuya Higashiyama Yasuhiro Ito Akihiro Miya |
| author_sort | Minoru Kihara |
| collection | DOAJ |
| description | Abstract Background Our previous kinetic analyses of changes in the tumor volume (TV) of papillary thyroid microcarcinomas during active surveillance revealed that the tumors’ growth varied over time from rather rapid growth to shrinkage and that the hypothetical TV-doubling rates (DRs) before the patients’ presentation were much larger than their observed TV-DRs, indicating that rapid growth phases preceded their presentation. Whether this phenomenon also occurs in medullary thyroid carcinoma (MTC) was unknown. Methods We retrospectively analyzed the cases of 46 MTC patients (18 hereditary, 28 sporadic; 9–80 years old at surgery, median 53.5 years; 19 males and 27 females) with elevated postoperative calcitonin (Ct) measured with the electrochemiluminescence immunoassay suggesting persistent disease. We calculated each patient’s Ct-DR and his/her hypothetical TV-DR, using the tumor size and age at surgery. Results Ct-DRs (/year) after surgery were > 0.5, 0.1–0.5, − 0.1–0.1, and < − 0.1 in 9, 21, 12, and 4 patients, respectively (median 0.17). The hypothetical TV-DRs (/year) before surgery were > 1, 0.5–1.0, 0.1–0.5 and < 0.1 in 11, 21, 14, and 0 patients, respectively (median 0.60). The hypothetical TV-DR was higher than the observed Ct-DR in 41 of the 46 MTC patients and all 18 patients with hereditary MTC, suggesting that a rapid growth phase preceded surgery in these patients. Conclusions In this series of MTC patients, the pre-surgery calculated hypothetical TV-DRs were significantly higher than the Ct-DRs observed post-surgery, suggesting that there were rapid growth periods before surgery in the vast majority of these MTC patients. |
| first_indexed | 2024-12-22T13:22:59Z |
| format | Article |
| id | doaj.art-0c7ce3d6e249434194e391414c0859ef |
| institution | Directory Open Access Journal |
| issn | 1756-6614 |
| language | English |
| last_indexed | 2024-12-22T13:22:59Z |
| publishDate | 2020-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Thyroid Research |
| spelling | doaj.art-0c7ce3d6e249434194e391414c0859ef2022-12-21T18:24:24ZengBMCThyroid Research1756-66142020-07-011311710.1186/s13044-020-00087-6Kinetic analysis of the growth rate of sporadic and hereditary medullary thyroid carcinoma: comparing the postoperative calcitonin-doubling rate with the hypothetical preoperative tumor volume-doubling rateMinoru Kihara0Akira Miyauchi1Hiroo Masuoka2Takuya Higashiyama3Yasuhiro Ito4Akihiro Miya5Department of Surgery, Kuma HospitalDepartment of Surgery, Kuma HospitalDepartment of Surgery, Kuma HospitalDepartment of Surgery, Kuma HospitalDepartment of Surgery, Kuma HospitalDepartment of Surgery, Kuma HospitalAbstract Background Our previous kinetic analyses of changes in the tumor volume (TV) of papillary thyroid microcarcinomas during active surveillance revealed that the tumors’ growth varied over time from rather rapid growth to shrinkage and that the hypothetical TV-doubling rates (DRs) before the patients’ presentation were much larger than their observed TV-DRs, indicating that rapid growth phases preceded their presentation. Whether this phenomenon also occurs in medullary thyroid carcinoma (MTC) was unknown. Methods We retrospectively analyzed the cases of 46 MTC patients (18 hereditary, 28 sporadic; 9–80 years old at surgery, median 53.5 years; 19 males and 27 females) with elevated postoperative calcitonin (Ct) measured with the electrochemiluminescence immunoassay suggesting persistent disease. We calculated each patient’s Ct-DR and his/her hypothetical TV-DR, using the tumor size and age at surgery. Results Ct-DRs (/year) after surgery were > 0.5, 0.1–0.5, − 0.1–0.1, and < − 0.1 in 9, 21, 12, and 4 patients, respectively (median 0.17). The hypothetical TV-DRs (/year) before surgery were > 1, 0.5–1.0, 0.1–0.5 and < 0.1 in 11, 21, 14, and 0 patients, respectively (median 0.60). The hypothetical TV-DR was higher than the observed Ct-DR in 41 of the 46 MTC patients and all 18 patients with hereditary MTC, suggesting that a rapid growth phase preceded surgery in these patients. Conclusions In this series of MTC patients, the pre-surgery calculated hypothetical TV-DRs were significantly higher than the Ct-DRs observed post-surgery, suggesting that there were rapid growth periods before surgery in the vast majority of these MTC patients.http://link.springer.com/article/10.1186/s13044-020-00087-6Kinetic analysis of the growth rateDoubling rateMedullary thyroid carcinomaCalcitoninTumor volume |
| spellingShingle | Minoru Kihara Akira Miyauchi Hiroo Masuoka Takuya Higashiyama Yasuhiro Ito Akihiro Miya Kinetic analysis of the growth rate of sporadic and hereditary medullary thyroid carcinoma: comparing the postoperative calcitonin-doubling rate with the hypothetical preoperative tumor volume-doubling rate Thyroid Research Kinetic analysis of the growth rate Doubling rate Medullary thyroid carcinoma Calcitonin Tumor volume |
| title | Kinetic analysis of the growth rate of sporadic and hereditary medullary thyroid carcinoma: comparing the postoperative calcitonin-doubling rate with the hypothetical preoperative tumor volume-doubling rate |
| title_full | Kinetic analysis of the growth rate of sporadic and hereditary medullary thyroid carcinoma: comparing the postoperative calcitonin-doubling rate with the hypothetical preoperative tumor volume-doubling rate |
| title_fullStr | Kinetic analysis of the growth rate of sporadic and hereditary medullary thyroid carcinoma: comparing the postoperative calcitonin-doubling rate with the hypothetical preoperative tumor volume-doubling rate |
| title_full_unstemmed | Kinetic analysis of the growth rate of sporadic and hereditary medullary thyroid carcinoma: comparing the postoperative calcitonin-doubling rate with the hypothetical preoperative tumor volume-doubling rate |
| title_short | Kinetic analysis of the growth rate of sporadic and hereditary medullary thyroid carcinoma: comparing the postoperative calcitonin-doubling rate with the hypothetical preoperative tumor volume-doubling rate |
| title_sort | kinetic analysis of the growth rate of sporadic and hereditary medullary thyroid carcinoma comparing the postoperative calcitonin doubling rate with the hypothetical preoperative tumor volume doubling rate |
| topic | Kinetic analysis of the growth rate Doubling rate Medullary thyroid carcinoma Calcitonin Tumor volume |
| url | http://link.springer.com/article/10.1186/s13044-020-00087-6 |
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