Propofol directly increases tau phosphorylation.

Propofol directly increases tau phosphorylation.

In Alzheimer's disease (AD) and other tauopathies, the microtubule-associated protein tau can undergo aberrant hyperphosphorylation potentially leading to the development of neurofibrillary pathology. Anesthetics have been previously shown to induce tau hyperphosphorylation through a mechanism...

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Bibliographic Details
Main Authors: Robert A Whittington, László Virág, François Marcouiller, Marie-Amélie Papon, Noura B El Khoury, Carl Julien, Françoise Morin, Charles W Emala, Emmanuel Planel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3031597?pdf=render

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