Adiponectin gene polymorphisms contributes to ischemic stroke risk: A meta-analysis
Background: Previous studies have reported the relation between the adiponectin polymorphisms and the risk of ischemic stroke. However, the findings is inclusive. In the present study, we performed a meta-analysis to clarify the relation between the adiponectin polymorphisms and the stroke. Methods:...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publications
2015-03-01
|
| Series: | Journal of the Renin-Angiotensin-Aldosterone System |
| Online Access: | https://doi.org/10.1177/1470320314552311 |
| _version_ | 1797281857791852544 |
|---|---|
| author | Dingzhu Shen Sanli Xing Chuan Chen |
| author_facet | Dingzhu Shen Sanli Xing Chuan Chen |
| author_sort | Dingzhu Shen |
| collection | DOAJ |
| description | Background: Previous studies have reported the relation between the adiponectin polymorphisms and the risk of ischemic stroke. However, the findings is inclusive. In the present study, we performed a meta-analysis to clarify the relation between the adiponectin polymorphisms and the stroke. Methods: Relevant studies were identified by searching PubMed, EMBASE, ISI Web of Science, ScienceDirect, Wiley Online Library, Wanfang database in China, and Chinese National Knowledge Infrastructure databases (CNKI) through July 2013 and other method such as reviewing the reference of retrieved literatures. We selected literatures that reported Odds ratio (OR) and 95% confidence interval (CI) for the relation between the ischemic stroke and the adiponectin genetic polymorphisms. With 1720 stroke cases and 5549 controls, were included. Our results showed that rs2241766 was associated with the risk of ischemic stroke in a recessive model (GG vs (TT+TG), OR = 1.29, 95% CI: 1.01–1.64, p = 0.04). However, rs1501299 and rs266729 were not found to be associated with ischemic stroke in our analysis. Conclusion: The present study suggested that rs2241766 polymorphism of adiponectin gene was associated with the risk for ischemic stroke. |
| first_indexed | 2024-03-07T17:03:30Z |
| format | Article |
| id | doaj.art-0c7f70aef3a447ab8d4905638bb29519 |
| institution | Directory Open Access Journal |
| issn | 1470-3203 1752-8976 |
| language | English |
| last_indexed | 2024-03-07T17:03:30Z |
| publishDate | 2015-03-01 |
| publisher | SAGE Publications |
| record_format | Article |
| series | Journal of the Renin-Angiotensin-Aldosterone System |
| spelling | doaj.art-0c7f70aef3a447ab8d4905638bb295192024-03-03T02:50:34ZengSAGE PublicationsJournal of the Renin-Angiotensin-Aldosterone System1470-32031752-89762015-03-011610.1177/1470320314552311Adiponectin gene polymorphisms contributes to ischemic stroke risk: A meta-analysisDingzhu ShenSanli XingChuan ChenBackground: Previous studies have reported the relation between the adiponectin polymorphisms and the risk of ischemic stroke. However, the findings is inclusive. In the present study, we performed a meta-analysis to clarify the relation between the adiponectin polymorphisms and the stroke. Methods: Relevant studies were identified by searching PubMed, EMBASE, ISI Web of Science, ScienceDirect, Wiley Online Library, Wanfang database in China, and Chinese National Knowledge Infrastructure databases (CNKI) through July 2013 and other method such as reviewing the reference of retrieved literatures. We selected literatures that reported Odds ratio (OR) and 95% confidence interval (CI) for the relation between the ischemic stroke and the adiponectin genetic polymorphisms. With 1720 stroke cases and 5549 controls, were included. Our results showed that rs2241766 was associated with the risk of ischemic stroke in a recessive model (GG vs (TT+TG), OR = 1.29, 95% CI: 1.01–1.64, p = 0.04). However, rs1501299 and rs266729 were not found to be associated with ischemic stroke in our analysis. Conclusion: The present study suggested that rs2241766 polymorphism of adiponectin gene was associated with the risk for ischemic stroke.https://doi.org/10.1177/1470320314552311 |
| spellingShingle | Dingzhu Shen Sanli Xing Chuan Chen Adiponectin gene polymorphisms contributes to ischemic stroke risk: A meta-analysis Journal of the Renin-Angiotensin-Aldosterone System |
| title | Adiponectin gene polymorphisms contributes to ischemic stroke risk: A meta-analysis |
| title_full | Adiponectin gene polymorphisms contributes to ischemic stroke risk: A meta-analysis |
| title_fullStr | Adiponectin gene polymorphisms contributes to ischemic stroke risk: A meta-analysis |
| title_full_unstemmed | Adiponectin gene polymorphisms contributes to ischemic stroke risk: A meta-analysis |
| title_short | Adiponectin gene polymorphisms contributes to ischemic stroke risk: A meta-analysis |
| title_sort | adiponectin gene polymorphisms contributes to ischemic stroke risk a meta analysis |
| url | https://doi.org/10.1177/1470320314552311 |
| work_keys_str_mv | AT dingzhushen adiponectingenepolymorphismscontributestoischemicstrokeriskametaanalysis AT sanlixing adiponectingenepolymorphismscontributestoischemicstrokeriskametaanalysis AT chuanchen adiponectingenepolymorphismscontributestoischemicstrokeriskametaanalysis |