Nephroprotective effect of AT-MSCs against cisplatin-induced EMT is improved by azilsartan via attenuating oxidative stress and TGF-β/Smad signaling

Nephroprotective effect of AT-MSCs against cisplatin-induced EMT is improved by azilsartan via attenuating oxidative stress and TGF-β/Smad signaling

The nephrotoxicity of cisplatin (CIS) is a significant complication that challenges its clinical applicability. The epithelial to mesenchymal transition (EMT) may be included in the pathogenesis of CIS-evoked nephrotoxicity. Therefore, the current study aimed to evaluate, for the first time, the pos...

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Bibliographic Details
Main Authors: Michael A. Fawzy, Olivia N. Beshay, Amany Abdlrehim Bekhit, Sara Mohamed Naguib Abdel-Hafez, Gaber El-Saber Batiha, Yousef A. Bin Jardan, Moustafa Fathy
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Adipose tissue-derived mesenchymal stem cells
Azilsartan
Cisplatin
Nephrotoxicity
Epithelial to mesenchymal transition
TGF-β/Smad
Online Access:http://www.sciencedirect.com/science/article/pii/S075333222201486X

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