The interplay between noncoding RNAs and drug resistance in hepatocellular carcinoma: the big impact of little things
Abstract Hepatocellular carcinoma (HCC) is the leading cause of cancer-related death in people, and a common primary liver cancer. Lacking early diagnosis and a high recurrence rate after surgical resection, systemic treatment is still an important treatment method for advanced HCC. Different drugs...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-06-01
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| Series: | Journal of Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12967-023-04238-9 |
| _version_ | 1797806481658085376 |
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| author | Yuan Fang XiaoLi Zhang HanFei Huang Zhong Zeng |
| author_facet | Yuan Fang XiaoLi Zhang HanFei Huang Zhong Zeng |
| author_sort | Yuan Fang |
| collection | DOAJ |
| description | Abstract Hepatocellular carcinoma (HCC) is the leading cause of cancer-related death in people, and a common primary liver cancer. Lacking early diagnosis and a high recurrence rate after surgical resection, systemic treatment is still an important treatment method for advanced HCC. Different drugs have distinct curative effects, side effects and drug resistance due to different properties. At present, conventional molecular drugs for HCC have displayed some limitations, such as adverse drug reactions, insensitivity to some medicines, and drug resistance. Noncoding RNAs (ncRNAs), including microRNAs (miRNAs), long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs), have been well documented to be involved in the occurrence and progression of cancer. Novel biomarkers and therapeutic targets, as well as research into the molecular basis of drug resistance, are urgently needed for the management of HCC. We review current research on ncRNAs and consolidate the known roles regulating drug resistance in HCC and examine the potential clinical applications of ncRNAs in overcoming drug resistance barriers in HCC based on targeted therapy, cell cycle non-specific chemotherapy and cell cycle specific chemotherapy. |
| first_indexed | 2024-03-13T06:07:59Z |
| format | Article |
| id | doaj.art-0c82024ea9e74a3891677a7fd6e91036 |
| institution | Directory Open Access Journal |
| issn | 1479-5876 |
| language | English |
| last_indexed | 2024-03-13T06:07:59Z |
| publishDate | 2023-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj.art-0c82024ea9e74a3891677a7fd6e910362023-06-11T11:24:03ZengBMCJournal of Translational Medicine1479-58762023-06-0121111410.1186/s12967-023-04238-9The interplay between noncoding RNAs and drug resistance in hepatocellular carcinoma: the big impact of little thingsYuan Fang0XiaoLi Zhang1HanFei Huang2Zhong Zeng3Organ Transplantation Center, The First Affiliated Hospital of Kunming Medical UniversityGastrointestinal and Hernia Surgery, The First Affiliated Hospital of Kunming Medical UniversityOrgan Transplantation Center, The First Affiliated Hospital of Kunming Medical UniversityOrgan Transplantation Center, The First Affiliated Hospital of Kunming Medical UniversityAbstract Hepatocellular carcinoma (HCC) is the leading cause of cancer-related death in people, and a common primary liver cancer. Lacking early diagnosis and a high recurrence rate after surgical resection, systemic treatment is still an important treatment method for advanced HCC. Different drugs have distinct curative effects, side effects and drug resistance due to different properties. At present, conventional molecular drugs for HCC have displayed some limitations, such as adverse drug reactions, insensitivity to some medicines, and drug resistance. Noncoding RNAs (ncRNAs), including microRNAs (miRNAs), long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs), have been well documented to be involved in the occurrence and progression of cancer. Novel biomarkers and therapeutic targets, as well as research into the molecular basis of drug resistance, are urgently needed for the management of HCC. We review current research on ncRNAs and consolidate the known roles regulating drug resistance in HCC and examine the potential clinical applications of ncRNAs in overcoming drug resistance barriers in HCC based on targeted therapy, cell cycle non-specific chemotherapy and cell cycle specific chemotherapy.https://doi.org/10.1186/s12967-023-04238-9Hepatocellular carcinomaNoncoding RNAsDrug resistanceTargeted therapyImmune therapy |
| spellingShingle | Yuan Fang XiaoLi Zhang HanFei Huang Zhong Zeng The interplay between noncoding RNAs and drug resistance in hepatocellular carcinoma: the big impact of little things Journal of Translational Medicine Hepatocellular carcinoma Noncoding RNAs Drug resistance Targeted therapy Immune therapy |
| title | The interplay between noncoding RNAs and drug resistance in hepatocellular carcinoma: the big impact of little things |
| title_full | The interplay between noncoding RNAs and drug resistance in hepatocellular carcinoma: the big impact of little things |
| title_fullStr | The interplay between noncoding RNAs and drug resistance in hepatocellular carcinoma: the big impact of little things |
| title_full_unstemmed | The interplay between noncoding RNAs and drug resistance in hepatocellular carcinoma: the big impact of little things |
| title_short | The interplay between noncoding RNAs and drug resistance in hepatocellular carcinoma: the big impact of little things |
| title_sort | interplay between noncoding rnas and drug resistance in hepatocellular carcinoma the big impact of little things |
| topic | Hepatocellular carcinoma Noncoding RNAs Drug resistance Targeted therapy Immune therapy |
| url | https://doi.org/10.1186/s12967-023-04238-9 |
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