Probiotic or probiotics add supplement interferes with coronary heart disease: A meta‐analysis of randomized controlled trials
Abstract The effect of probiotics or probiotics add supplement on improving clinical outcomes of coronary heart disease (CHD) has produced conflicting results. This meta‐analysis aimed to evaluate the effect of probiotics supplementation or probiotics add supplement on blood glucose, lipids, blood p...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-12-01
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| Series: | eFood |
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| Online Access: | https://doi.org/10.1002/efd2.120 |
| _version_ | 1827589888080347136 |
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| author | Lingshuang Yang Jumei Zhang Juan Wang Hui Zhao Xinqiang Xie Qingping Wu |
| author_facet | Lingshuang Yang Jumei Zhang Juan Wang Hui Zhao Xinqiang Xie Qingping Wu |
| author_sort | Lingshuang Yang |
| collection | DOAJ |
| description | Abstract The effect of probiotics or probiotics add supplement on improving clinical outcomes of coronary heart disease (CHD) has produced conflicting results. This meta‐analysis aimed to evaluate the effect of probiotics supplementation or probiotics add supplement on blood glucose, lipids, blood pressure, inflammatory reaction, oxidative stress, and depress score in patients with CHD. Search PubMed, Web of Science, Embase, and Cochrane Library databases for relevant studies from February 1974 to September 2022. Pooled results were calculated using a fixed‐effect model to assess the effects of probiotics supplementation or probiotics add supplement in CHD. A total of 10 randomized controlled trials were included in this analysis. Overall, probiotics add supplement showed statistically significant reductions in triglycerides, insulin, homeostasis model of assessment‐insulin resistance (HOMA‐IR), high‐sensitivity C‐reactive protein (hs‐CRP), interleukin‐6, and Beck Depression Inventory (BDI) score, compared to the control group (standardized mean difference [SMD]: −0.35 mg/dL; SMD: −0.64 μIU/mL; SMD: −0.90; SMD: −0.57 mg/dL; SMD: −0.60 pg/mL; SMD: −0.52; respectively), but high‐density lipoprotein cholesterol, nitric oxide (NO) were statistically significant increased (SMD: 0.45 mg/dL; SMD: 1.01 μmol/L; respectively). Then, probiotics showed statistically significant reductions in hs‐CRP, and Beck Anxiety Inventory score BDI (SMD: −0.50 mg/dL; SMD: −0.67; SMD: −0.41; respectively). Moreover, subgroup analyses revealed that low‐density lipoprotein cholesterol, HOMA‐IR, diastolic blood pressure, NO indicators may influence by patients age, body mass index (BMI), duration of the supplement and dose of probiotics. Our analysis showed that probiotics supplementation or probiotics add supplement improved glucolipid metabolism, inflammatory response, oxidative stress, and depressive disorder, particularly the patients who ages ≥60, baseline BMI <30 kg/m2, duration of intervention more than 12 weeks and the dose of probiotics ≥8 × 109 CFU/day. The PROSPERO ID was CRD42022357385. |
| first_indexed | 2024-03-09T01:08:16Z |
| format | Article |
| id | doaj.art-0c8397b7b6934d4d976a11dff68d8183 |
| institution | Directory Open Access Journal |
| issn | 2666-3066 |
| language | English |
| last_indexed | 2024-03-09T01:08:16Z |
| publishDate | 2023-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | eFood |
| spelling | doaj.art-0c8397b7b6934d4d976a11dff68d81832023-12-11T08:56:28ZengWileyeFood2666-30662023-12-0146n/an/a10.1002/efd2.120Probiotic or probiotics add supplement interferes with coronary heart disease: A meta‐analysis of randomized controlled trialsLingshuang Yang0Jumei Zhang1Juan Wang2Hui Zhao3Xinqiang Xie4Qingping Wu5College of Food Science South China Agricultural University Guangzhou Guangdong ChinaGuangdong Provincial Key Laboratory of Microbial Safety and Health, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology Guangdong Academy of Sciences Guangzhou ChinaCollege of Food Science South China Agricultural University Guangzhou Guangdong ChinaGuangdong Provincial Key Laboratory of Microbial Safety and Health, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology Guangdong Academy of Sciences Guangzhou ChinaGuangdong Provincial Key Laboratory of Microbial Safety and Health, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology Guangdong Academy of Sciences Guangzhou ChinaGuangdong Provincial Key Laboratory of Microbial Safety and Health, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology Guangdong Academy of Sciences Guangzhou ChinaAbstract The effect of probiotics or probiotics add supplement on improving clinical outcomes of coronary heart disease (CHD) has produced conflicting results. This meta‐analysis aimed to evaluate the effect of probiotics supplementation or probiotics add supplement on blood glucose, lipids, blood pressure, inflammatory reaction, oxidative stress, and depress score in patients with CHD. Search PubMed, Web of Science, Embase, and Cochrane Library databases for relevant studies from February 1974 to September 2022. Pooled results were calculated using a fixed‐effect model to assess the effects of probiotics supplementation or probiotics add supplement in CHD. A total of 10 randomized controlled trials were included in this analysis. Overall, probiotics add supplement showed statistically significant reductions in triglycerides, insulin, homeostasis model of assessment‐insulin resistance (HOMA‐IR), high‐sensitivity C‐reactive protein (hs‐CRP), interleukin‐6, and Beck Depression Inventory (BDI) score, compared to the control group (standardized mean difference [SMD]: −0.35 mg/dL; SMD: −0.64 μIU/mL; SMD: −0.90; SMD: −0.57 mg/dL; SMD: −0.60 pg/mL; SMD: −0.52; respectively), but high‐density lipoprotein cholesterol, nitric oxide (NO) were statistically significant increased (SMD: 0.45 mg/dL; SMD: 1.01 μmol/L; respectively). Then, probiotics showed statistically significant reductions in hs‐CRP, and Beck Anxiety Inventory score BDI (SMD: −0.50 mg/dL; SMD: −0.67; SMD: −0.41; respectively). Moreover, subgroup analyses revealed that low‐density lipoprotein cholesterol, HOMA‐IR, diastolic blood pressure, NO indicators may influence by patients age, body mass index (BMI), duration of the supplement and dose of probiotics. Our analysis showed that probiotics supplementation or probiotics add supplement improved glucolipid metabolism, inflammatory response, oxidative stress, and depressive disorder, particularly the patients who ages ≥60, baseline BMI <30 kg/m2, duration of intervention more than 12 weeks and the dose of probiotics ≥8 × 109 CFU/day. The PROSPERO ID was CRD42022357385.https://doi.org/10.1002/efd2.120coronary heart diseasedepressive disorderglucolipid metabolisminflammationoxidative stressprobiotic |
| spellingShingle | Lingshuang Yang Jumei Zhang Juan Wang Hui Zhao Xinqiang Xie Qingping Wu Probiotic or probiotics add supplement interferes with coronary heart disease: A meta‐analysis of randomized controlled trials eFood coronary heart disease depressive disorder glucolipid metabolism inflammation oxidative stress probiotic |
| title | Probiotic or probiotics add supplement interferes with coronary heart disease: A meta‐analysis of randomized controlled trials |
| title_full | Probiotic or probiotics add supplement interferes with coronary heart disease: A meta‐analysis of randomized controlled trials |
| title_fullStr | Probiotic or probiotics add supplement interferes with coronary heart disease: A meta‐analysis of randomized controlled trials |
| title_full_unstemmed | Probiotic or probiotics add supplement interferes with coronary heart disease: A meta‐analysis of randomized controlled trials |
| title_short | Probiotic or probiotics add supplement interferes with coronary heart disease: A meta‐analysis of randomized controlled trials |
| title_sort | probiotic or probiotics add supplement interferes with coronary heart disease a meta analysis of randomized controlled trials |
| topic | coronary heart disease depressive disorder glucolipid metabolism inflammation oxidative stress probiotic |
| url | https://doi.org/10.1002/efd2.120 |
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