Mutations in <i>KMT2C</i>, <i>BCOR</i> and <i>KDM5C</i> Predict Response to Immune Checkpoint Blockade Therapy in Non-Small Cell Lung Cancer

Mutations in <i>KMT2C</i>, <i>BCOR</i> and <i>KDM5C</i> Predict Response to Immune Checkpoint Blockade Therapy in Non-Small Cell Lung Cancer

Efficient predictive biomarkers are urgently needed to identify non-small cell lung cancer (NSCLC) patients who could benefit from immune checkpoint blockade (ICB) therapy. Since chromatin remodeling is required for DNA repair process, we asked whether mutations in chromatin remodeling genes could i...

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Bibliographic Details
Main Authors: Dingxie Liu, Jonathan Benzaquen, Luc G. T. Morris, Marius Ilié, Paul Hofman
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Cancers
Subjects:
chromatin remodeling
immune checkpoint blockade
response prediction
non-small cell lung cancer
tumor mutation burden
Online Access:https://www.mdpi.com/2072-6694/14/11/2816

Internet

https://www.mdpi.com/2072-6694/14/11/2816

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