MRAP2 regulates ghrelin receptor signaling and hunger sensing
Melanocortin receptor accessory protein 2 (MRAP2) is an adaptor protein that contributes to melanocortin-4 receptor and prokineticin receptor 1 signalling. Here the authors show that MRAP2 also regulates ghrelin receptor signalling in the hypothalamus and starvation sensing in mice.
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-00747-6 |
| _version_ | 1818990599010779136 |
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| author | Dollada Srisai Terry C. Yin Abigail A. Lee Alix A. J. Rouault Nicole A. Pearson Justin L. Grobe Julien A. Sebag |
| author_facet | Dollada Srisai Terry C. Yin Abigail A. Lee Alix A. J. Rouault Nicole A. Pearson Justin L. Grobe Julien A. Sebag |
| author_sort | Dollada Srisai |
| collection | DOAJ |
| description | Melanocortin receptor accessory protein 2 (MRAP2) is an adaptor protein that contributes to melanocortin-4 receptor and prokineticin receptor 1 signalling. Here the authors show that MRAP2 also regulates ghrelin receptor signalling in the hypothalamus and starvation sensing in mice. |
| first_indexed | 2024-12-20T19:56:56Z |
| format | Article |
| id | doaj.art-0c8ac5f69f6445bd9e9a8456fe6f8bef |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T19:56:56Z |
| publishDate | 2017-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-0c8ac5f69f6445bd9e9a8456fe6f8bef2022-12-21T19:28:08ZengNature PortfolioNature Communications2041-17232017-09-018111010.1038/s41467-017-00747-6MRAP2 regulates ghrelin receptor signaling and hunger sensingDollada Srisai0Terry C. Yin1Abigail A. Lee2Alix A. J. Rouault3Nicole A. Pearson4Justin L. Grobe5Julien A. Sebag6Department of Molecular Physiology and Biophysics, University of Iowa, Carver College of MedicineDepartment of Molecular Physiology and Biophysics, University of Iowa, Carver College of MedicineDepartment of Molecular Physiology and Biophysics, University of Iowa, Carver College of MedicineDepartment of Molecular Physiology and Biophysics, University of Iowa, Carver College of MedicineF.O.E.D.R.CF.O.E.D.R.CDepartment of Molecular Physiology and Biophysics, University of Iowa, Carver College of MedicineMelanocortin receptor accessory protein 2 (MRAP2) is an adaptor protein that contributes to melanocortin-4 receptor and prokineticin receptor 1 signalling. Here the authors show that MRAP2 also regulates ghrelin receptor signalling in the hypothalamus and starvation sensing in mice.https://doi.org/10.1038/s41467-017-00747-6 |
| spellingShingle | Dollada Srisai Terry C. Yin Abigail A. Lee Alix A. J. Rouault Nicole A. Pearson Justin L. Grobe Julien A. Sebag MRAP2 regulates ghrelin receptor signaling and hunger sensing Nature Communications |
| title | MRAP2 regulates ghrelin receptor signaling and hunger sensing |
| title_full | MRAP2 regulates ghrelin receptor signaling and hunger sensing |
| title_fullStr | MRAP2 regulates ghrelin receptor signaling and hunger sensing |
| title_full_unstemmed | MRAP2 regulates ghrelin receptor signaling and hunger sensing |
| title_short | MRAP2 regulates ghrelin receptor signaling and hunger sensing |
| title_sort | mrap2 regulates ghrelin receptor signaling and hunger sensing |
| url | https://doi.org/10.1038/s41467-017-00747-6 |
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