Bioprinting for bone tissue engineering
The shape transformation characteristics of four-dimensional (4D)-printed bone structures can meet the individual bone regeneration needs, while their structure can be programmed to cross-link or reassemble by stimulating responsive materials. At the same time, it can be used to design vascularized...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.1036375/full |
| _version_ | 1811305064646574080 |
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| author | Xin Kang Xiao-Bo Zhang Xi-Dan Gao Ding-Jun Hao Tao Li Zheng-Wei Xu |
| author_facet | Xin Kang Xiao-Bo Zhang Xi-Dan Gao Ding-Jun Hao Tao Li Zheng-Wei Xu |
| author_sort | Xin Kang |
| collection | DOAJ |
| description | The shape transformation characteristics of four-dimensional (4D)-printed bone structures can meet the individual bone regeneration needs, while their structure can be programmed to cross-link or reassemble by stimulating responsive materials. At the same time, it can be used to design vascularized bone structures that help establish a bionic microenvironment, thus influencing cellular behavior and enhancing stem cell differentiation in the postprinting phase. These developments significantly improve conventional three-dimensional (3D)-printed bone structures with enhanced functional adaptability, providing theoretical support to fabricate bone structures to adapt to defective areas dynamically. The printing inks used are stimulus-responsive materials that enable spatiotemporal distribution, maintenance of bioactivity and cellular release for bone, vascular and neural tissue regeneration. This paper discusses the limitations of current bone defect therapies, 4D printing materials used to stimulate bone tissue engineering (e.g., hydrogels), the printing process, the printing classification and their value for clinical applications. We focus on summarizing the technical challenges faced to provide novel therapeutic implications for bone defect repair. |
| first_indexed | 2024-04-13T08:18:40Z |
| format | Article |
| id | doaj.art-0c8b45095ee546959b352d204f118104 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-13T08:18:40Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-0c8b45095ee546959b352d204f1181042022-12-22T02:54:42ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-11-011010.3389/fbioe.2022.10363751036375Bioprinting for bone tissue engineeringXin Kang0Xiao-Bo Zhang1Xi-Dan Gao2Ding-Jun Hao3Tao Li4Zheng-Wei Xu5Department of Spine Surgery, Honghui Hospital, Xi’an Jiao Tong University, Xian, Shaanxi, ChinaDepartment of Spine Surgery, Honghui Hospital, Xi’an Jiao Tong University, Xian, Shaanxi, ChinaDepartment of Orthopedics, Lanzhou University Second Hospital, Lanzhou, Gansu, ChinaDepartment of Spine Surgery, Honghui Hospital, Xi’an Jiao Tong University, Xian, Shaanxi, ChinaDepartment of Spine Surgery, Honghui Hospital, Xi’an Jiao Tong University, Xian, Shaanxi, ChinaDepartment of Spine Surgery, Honghui Hospital, Xi’an Jiao Tong University, Xian, Shaanxi, ChinaThe shape transformation characteristics of four-dimensional (4D)-printed bone structures can meet the individual bone regeneration needs, while their structure can be programmed to cross-link or reassemble by stimulating responsive materials. At the same time, it can be used to design vascularized bone structures that help establish a bionic microenvironment, thus influencing cellular behavior and enhancing stem cell differentiation in the postprinting phase. These developments significantly improve conventional three-dimensional (3D)-printed bone structures with enhanced functional adaptability, providing theoretical support to fabricate bone structures to adapt to defective areas dynamically. The printing inks used are stimulus-responsive materials that enable spatiotemporal distribution, maintenance of bioactivity and cellular release for bone, vascular and neural tissue regeneration. This paper discusses the limitations of current bone defect therapies, 4D printing materials used to stimulate bone tissue engineering (e.g., hydrogels), the printing process, the printing classification and their value for clinical applications. We focus on summarizing the technical challenges faced to provide novel therapeutic implications for bone defect repair.https://www.frontiersin.org/articles/10.3389/fbioe.2022.1036375/fullfour-dimensional bioprintingstimulus-responsivebone tissue engineeringchallengesreview |
| spellingShingle | Xin Kang Xiao-Bo Zhang Xi-Dan Gao Ding-Jun Hao Tao Li Zheng-Wei Xu Bioprinting for bone tissue engineering Frontiers in Bioengineering and Biotechnology four-dimensional bioprinting stimulus-responsive bone tissue engineering challenges review |
| title | Bioprinting for bone tissue engineering |
| title_full | Bioprinting for bone tissue engineering |
| title_fullStr | Bioprinting for bone tissue engineering |
| title_full_unstemmed | Bioprinting for bone tissue engineering |
| title_short | Bioprinting for bone tissue engineering |
| title_sort | bioprinting for bone tissue engineering |
| topic | four-dimensional bioprinting stimulus-responsive bone tissue engineering challenges review |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.1036375/full |
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