Primary breast tumor induced extracellular matrix remodeling in premetastatic lungs

Primary breast tumor induced extracellular matrix remodeling in premetastatic lungs

Abstract The premetastatic niche hypothesis proposes an active priming of the metastatic site by factors secreted from the primary tumor prior to the arrival of the first cancer cells. We investigated several extracellular matrix (ECM) structural proteins, ECM degrading enzymes, and ECM processing p...

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Bibliographic Details
Main Authors: Ruoqing Cai, Caitlin M. Tressler, Menglin Cheng, Kanchan Sonkar, Zheqiong Tan, Santosh Kumar Paidi, Vinay Ayyappan, Ishan Barman, Kristine Glunde
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-45832-7

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