Effect of Vitamin C on Tendinopathy Recovery: A Scoping Review
Tendinopathies represent 30–50% of all sports injuries. The tendon response is influenced by the load (volume, intensity, and frequency) that the tendon support, resulting in irritability and pain, among others. The main molecular component of tendons is collagen I (60–85%). The rest consist of glyc...
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MDPI AG
2022-06-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/13/2663 |
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| author | David C. Noriega-González Franchek Drobnic Alberto Caballero-García Enrique Roche Daniel Perez-Valdecantos Alfredo Córdova |
| author_facet | David C. Noriega-González Franchek Drobnic Alberto Caballero-García Enrique Roche Daniel Perez-Valdecantos Alfredo Córdova |
| author_sort | David C. Noriega-González |
| collection | DOAJ |
| description | Tendinopathies represent 30–50% of all sports injuries. The tendon response is influenced by the load (volume, intensity, and frequency) that the tendon support, resulting in irritability and pain, among others. The main molecular component of tendons is collagen I (60–85%). The rest consist of glycosaminoglycans-proteoglycans, glycoproteins, and other collagen subtypes. This study’s aim was to critically evaluate the efficacy of vitamin C supplementation in the treatment of tendinopathies. At the same time, the study aims to determine the optimal conditions (dose and time) for vitamin C supplementation. A structured search was carried out in the SCOPUS, Medline (PubMed), and Web of Science (WOS) databases. The inclusion criteria took into account studies describing optimal tendon recovery when using vitamin C alone or in combination with other compounds. The study design was considered, including randomized, double-blind controlled, and parallel designs in animal models or humans. The main outcome is that vitamin C supplementation is potentially useful as a therapeutic approach for tendinopathy recovery. Vitamin C supplementation, alone or in combination with other products, increases collagen synthesis with a consequent improvement in the patient’s condition. On the other hand, vitamin C deficiency is mainly associated with a decrease in procollagen synthesis and reduced hydroxylation of proline and lysine residues, hindering the tendon repair process. |
| first_indexed | 2024-03-09T12:40:27Z |
| format | Article |
| id | doaj.art-0c8cc58d10564ad384c436039d272336 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T12:40:27Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-0c8cc58d10564ad384c436039d2723362023-11-30T22:17:59ZengMDPI AGNutrients2072-66432022-06-011413266310.3390/nu14132663Effect of Vitamin C on Tendinopathy Recovery: A Scoping ReviewDavid C. Noriega-González0Franchek Drobnic1Alberto Caballero-García2Enrique Roche3Daniel Perez-Valdecantos4Alfredo Córdova5Department of Surgery, Ophthalmology, Otorhinolaryngology and Physiotherapy, Faculty of Medicine, Hospital Clínico Universitario de Valladolid, 47002 Valladolid, SpainMedical Services Shanghai Shenhua FC, Shanghai 201315, ChinaDepartment of Anatomy and Radiology, Faculty of Health Sciences, GIR Physical Exercise and Aging, Campus Los Pajaritos, University of Valladolid, 42004 Soria, SpainDepartment of Applied Biology-Nutrition, Institute of Bioengineering, University Miguel Hernández, 03202 Elche, SpainDepartment of Biochemistry, Molecular Biology and Physiology, Faculty of Health Sciences, GIR Physical Exercise and Aging, Campus Duques de Soria, University of Valladolid, 42004 Soria, SpainDepartment of Biochemistry, Molecular Biology and Physiology, Faculty of Health Sciences, GIR Physical Exercise and Aging, Campus Duques de Soria, University of Valladolid, 42004 Soria, SpainTendinopathies represent 30–50% of all sports injuries. The tendon response is influenced by the load (volume, intensity, and frequency) that the tendon support, resulting in irritability and pain, among others. The main molecular component of tendons is collagen I (60–85%). The rest consist of glycosaminoglycans-proteoglycans, glycoproteins, and other collagen subtypes. This study’s aim was to critically evaluate the efficacy of vitamin C supplementation in the treatment of tendinopathies. At the same time, the study aims to determine the optimal conditions (dose and time) for vitamin C supplementation. A structured search was carried out in the SCOPUS, Medline (PubMed), and Web of Science (WOS) databases. The inclusion criteria took into account studies describing optimal tendon recovery when using vitamin C alone or in combination with other compounds. The study design was considered, including randomized, double-blind controlled, and parallel designs in animal models or humans. The main outcome is that vitamin C supplementation is potentially useful as a therapeutic approach for tendinopathy recovery. Vitamin C supplementation, alone or in combination with other products, increases collagen synthesis with a consequent improvement in the patient’s condition. On the other hand, vitamin C deficiency is mainly associated with a decrease in procollagen synthesis and reduced hydroxylation of proline and lysine residues, hindering the tendon repair process.https://www.mdpi.com/2072-6643/14/13/2663vitamin Cascorbic acidtendinopathycollagenoxidative stress |
| spellingShingle | David C. Noriega-González Franchek Drobnic Alberto Caballero-García Enrique Roche Daniel Perez-Valdecantos Alfredo Córdova Effect of Vitamin C on Tendinopathy Recovery: A Scoping Review Nutrients vitamin C ascorbic acid tendinopathy collagen oxidative stress |
| title | Effect of Vitamin C on Tendinopathy Recovery: A Scoping Review |
| title_full | Effect of Vitamin C on Tendinopathy Recovery: A Scoping Review |
| title_fullStr | Effect of Vitamin C on Tendinopathy Recovery: A Scoping Review |
| title_full_unstemmed | Effect of Vitamin C on Tendinopathy Recovery: A Scoping Review |
| title_short | Effect of Vitamin C on Tendinopathy Recovery: A Scoping Review |
| title_sort | effect of vitamin c on tendinopathy recovery a scoping review |
| topic | vitamin C ascorbic acid tendinopathy collagen oxidative stress |
| url | https://www.mdpi.com/2072-6643/14/13/2663 |
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