Association of microalbuminuria with metabolic syndrome: a cross-sectional study in Bangladesh

Abstract Background and aims The objectives of this study were to estimate the prevalence of microalbuminuria and examine the association of microalbuminuria with metabolic syndrome (MetS) and its component in a Bangladeshi adult cohort. Methods This cross-sectional study included 175 subjects (84 m...

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Main Authors: Muntakim Mahmud Saadi, Manindra Nath Roy, Rubena Haque, Farida Akhter Tania, Shakil Mahmood, Nurshad Ali
Format: Article
Language:English
Published: BMC 2020-10-01
Series:BMC Endocrine Disorders
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12902-020-00634-0
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author Muntakim Mahmud Saadi
Manindra Nath Roy
Rubena Haque
Farida Akhter Tania
Shakil Mahmood
Nurshad Ali
author_facet Muntakim Mahmud Saadi
Manindra Nath Roy
Rubena Haque
Farida Akhter Tania
Shakil Mahmood
Nurshad Ali
author_sort Muntakim Mahmud Saadi
collection DOAJ
description Abstract Background and aims The objectives of this study were to estimate the prevalence of microalbuminuria and examine the association of microalbuminuria with metabolic syndrome (MetS) and its component in a Bangladeshi adult cohort. Methods This cross-sectional study included 175 subjects (84 males and 91 females; aged 19–59 years), recruited from the outdoor Department of Medicine and Endocrinology of a medical college hospital in Dhaka, Bangladesh. Lipid profile and fasting blood glucose (FBG) were measured in serum and albumin and creatinine were determined in urine samples. Microalbuminuria was defined as the urinary albumin-to-creatinine ratio (ACR) of 30 to 300 mg/g. The MetS was defined according to the criteria of the National Cholesterol Education Program (NECP). The association of microalbuminuria with MetS and its components was evaluated by multivariate logistic regression analysis. Results Among the study subjects, 66.3% were hypertensive and 70.3% were diabetic individuals. Overall, the prevalence of microalbuminuria was 29.7% with 31% in males and 28.6% in females. Microalbuminuria was 2.6 fold higher in hypertensive and diabetic adults than in the non-hypertensive or non-diabetic adults. The prevalence of microalbuminuria was much more frequent in persons with the MetS (36.0%) than the persons without the MetS (5.4%). The levels of FBG, systolic blood pressure (SBP), diastolic blood pressure (DBP) and triglycerides were significantly higher (p < 0.01 for all cases) in subjects with microalbuminuria. In regression analysis, after adjusting for sex, age, and body mass index, microalbuminuria was strongly correlated with MetS followed by elevated BP and FBG (p < 0.01 for all cases). Conclusions Microalbuminuria was strongly associated with MetS in Bangladeshi adults. Elevated BP and FBG were the most predominant components of MetS among the study subjects. Comprehensive management of MetS at its early stage can be effective to prevent and reduce the progression of kidney injury and cardiovascular complications.
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spelling doaj.art-0c8db62dc67c425981b4f98719a64ae72022-12-21T22:51:33ZengBMCBMC Endocrine Disorders1472-68232020-10-012011710.1186/s12902-020-00634-0Association of microalbuminuria with metabolic syndrome: a cross-sectional study in BangladeshMuntakim Mahmud Saadi0Manindra Nath Roy1Rubena Haque2Farida Akhter Tania3Shakil Mahmood4Nurshad Ali5Department of Biochemistry, Netrokona Medical CollegeDepartment of Biochemistry, Sir Salimullah Medical CollegeDepartment of Biochemistry, Sir Salimullah Medical CollegeDepartment of Biochemistry, Ad-Din Women’s Medical CollegeDepartment of Biochemistry, Gonoshasthaya Samaj Vittik Medical College, SavarDepartment of Biochemistry and Molecular Biology, Shahjalal University of Science and TechnologyAbstract Background and aims The objectives of this study were to estimate the prevalence of microalbuminuria and examine the association of microalbuminuria with metabolic syndrome (MetS) and its component in a Bangladeshi adult cohort. Methods This cross-sectional study included 175 subjects (84 males and 91 females; aged 19–59 years), recruited from the outdoor Department of Medicine and Endocrinology of a medical college hospital in Dhaka, Bangladesh. Lipid profile and fasting blood glucose (FBG) were measured in serum and albumin and creatinine were determined in urine samples. Microalbuminuria was defined as the urinary albumin-to-creatinine ratio (ACR) of 30 to 300 mg/g. The MetS was defined according to the criteria of the National Cholesterol Education Program (NECP). The association of microalbuminuria with MetS and its components was evaluated by multivariate logistic regression analysis. Results Among the study subjects, 66.3% were hypertensive and 70.3% were diabetic individuals. Overall, the prevalence of microalbuminuria was 29.7% with 31% in males and 28.6% in females. Microalbuminuria was 2.6 fold higher in hypertensive and diabetic adults than in the non-hypertensive or non-diabetic adults. The prevalence of microalbuminuria was much more frequent in persons with the MetS (36.0%) than the persons without the MetS (5.4%). The levels of FBG, systolic blood pressure (SBP), diastolic blood pressure (DBP) and triglycerides were significantly higher (p < 0.01 for all cases) in subjects with microalbuminuria. In regression analysis, after adjusting for sex, age, and body mass index, microalbuminuria was strongly correlated with MetS followed by elevated BP and FBG (p < 0.01 for all cases). Conclusions Microalbuminuria was strongly associated with MetS in Bangladeshi adults. Elevated BP and FBG were the most predominant components of MetS among the study subjects. Comprehensive management of MetS at its early stage can be effective to prevent and reduce the progression of kidney injury and cardiovascular complications.http://link.springer.com/article/10.1186/s12902-020-00634-0MicroalbuminuriaMetabolic syndromePrevalenceBangladeshi adults
spellingShingle Muntakim Mahmud Saadi
Manindra Nath Roy
Rubena Haque
Farida Akhter Tania
Shakil Mahmood
Nurshad Ali
Association of microalbuminuria with metabolic syndrome: a cross-sectional study in Bangladesh
BMC Endocrine Disorders
Microalbuminuria
Metabolic syndrome
Prevalence
Bangladeshi adults
title Association of microalbuminuria with metabolic syndrome: a cross-sectional study in Bangladesh
title_full Association of microalbuminuria with metabolic syndrome: a cross-sectional study in Bangladesh
title_fullStr Association of microalbuminuria with metabolic syndrome: a cross-sectional study in Bangladesh
title_full_unstemmed Association of microalbuminuria with metabolic syndrome: a cross-sectional study in Bangladesh
title_short Association of microalbuminuria with metabolic syndrome: a cross-sectional study in Bangladesh
title_sort association of microalbuminuria with metabolic syndrome a cross sectional study in bangladesh
topic Microalbuminuria
Metabolic syndrome
Prevalence
Bangladeshi adults
url http://link.springer.com/article/10.1186/s12902-020-00634-0
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