Interaction of LRRK2 with kinase and GTPase signaling cascades

Interaction of LRRK2 with kinase and GTPase signaling cascades

LRRK2 is a protein that interacts with a plethora of signaling molecules, but the complexity of LRRK2 function presents a challenge for understanding the role of LRRK2 in the pathophysiology of Parkinson’s disease. Studies of LRRK2 using over-expression in transgenic mice have been disappointing, h...

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Bibliographic Details
Main Authors: Joon Y Boon, Julien eDusonchet, Chelsea eTrengrove, Benjamin eWolozin
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-07-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Autophagy
Cell Death
Cytoskeleton
Dopamine
trafficking
Actin
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2014.00064/full

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