Harnessing CD8<sup>+</sup>CD28<sup>−</sup> Regulatory T Cells as a Tool to Treat Autoimmune Disease
T regulatory cell therapy presents a novel therapeutic strategy for patients with autoimmune diseases or who are undergoing transplantation. At present, the CD4<sup>+</sup> Treg population has been extensively characterized, as a result of defined phenotypic and functional readouts. In t...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/11/2973 |
| _version_ | 1797510839411933184 |
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| author | Sabrina Ceeraz Charlotte R. Thompson Richard Beatson Ernest H. Choy |
| author_facet | Sabrina Ceeraz Charlotte R. Thompson Richard Beatson Ernest H. Choy |
| author_sort | Sabrina Ceeraz |
| collection | DOAJ |
| description | T regulatory cell therapy presents a novel therapeutic strategy for patients with autoimmune diseases or who are undergoing transplantation. At present, the CD4<sup>+</sup> Treg population has been extensively characterized, as a result of defined phenotypic and functional readouts. In this review article, we discuss the development and biology of CD8<sup>+</sup> Tregs and their role in murine and human disease indications. A subset of CD8<sup>+</sup> Tregs that lack the surface expression of CD28 (CD8<sup>+</sup>CD28<sup>−</sup> Treg) has proved efficacious in preclinical models. CD8<sup>+</sup>CD28<sup>−</sup> Tregs are present in healthy individuals, but their impaired functionality in disease renders them less effective in mediating immunosuppression. We primarily focus on harnessing CD8<sup>+</sup> Treg cell therapy in the clinic to support current treatment for patients with autoimmune or inflammatory conditions. |
| first_indexed | 2024-03-10T05:37:00Z |
| format | Article |
| id | doaj.art-0c8f856cc5e947cdb4c5cf8bd03897b0 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T05:37:00Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-0c8f856cc5e947cdb4c5cf8bd03897b02023-11-22T22:49:27ZengMDPI AGCells2073-44092021-11-011011297310.3390/cells10112973Harnessing CD8<sup>+</sup>CD28<sup>−</sup> Regulatory T Cells as a Tool to Treat Autoimmune DiseaseSabrina Ceeraz0Charlotte R. Thompson1Richard Beatson2Ernest H. Choy3Carisma Therapeutics, Philadelphia, PA 19104, USABrighton and Sussex Medical School, University of Sussex, Brighton BN1 9RH, UKSchool of Cancer & Pharmaceutical Sciences, Faculty of Life Sciences and Medicine, King’s College London, London SE1 9RT, UKCREATE Centre, Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UKT regulatory cell therapy presents a novel therapeutic strategy for patients with autoimmune diseases or who are undergoing transplantation. At present, the CD4<sup>+</sup> Treg population has been extensively characterized, as a result of defined phenotypic and functional readouts. In this review article, we discuss the development and biology of CD8<sup>+</sup> Tregs and their role in murine and human disease indications. A subset of CD8<sup>+</sup> Tregs that lack the surface expression of CD28 (CD8<sup>+</sup>CD28<sup>−</sup> Treg) has proved efficacious in preclinical models. CD8<sup>+</sup>CD28<sup>−</sup> Tregs are present in healthy individuals, but their impaired functionality in disease renders them less effective in mediating immunosuppression. We primarily focus on harnessing CD8<sup>+</sup> Treg cell therapy in the clinic to support current treatment for patients with autoimmune or inflammatory conditions.https://www.mdpi.com/2073-4409/10/11/2973CD8Tregautoimmunityimmunoregulation |
| spellingShingle | Sabrina Ceeraz Charlotte R. Thompson Richard Beatson Ernest H. Choy Harnessing CD8<sup>+</sup>CD28<sup>−</sup> Regulatory T Cells as a Tool to Treat Autoimmune Disease Cells CD8 Treg autoimmunity immunoregulation |
| title | Harnessing CD8<sup>+</sup>CD28<sup>−</sup> Regulatory T Cells as a Tool to Treat Autoimmune Disease |
| title_full | Harnessing CD8<sup>+</sup>CD28<sup>−</sup> Regulatory T Cells as a Tool to Treat Autoimmune Disease |
| title_fullStr | Harnessing CD8<sup>+</sup>CD28<sup>−</sup> Regulatory T Cells as a Tool to Treat Autoimmune Disease |
| title_full_unstemmed | Harnessing CD8<sup>+</sup>CD28<sup>−</sup> Regulatory T Cells as a Tool to Treat Autoimmune Disease |
| title_short | Harnessing CD8<sup>+</sup>CD28<sup>−</sup> Regulatory T Cells as a Tool to Treat Autoimmune Disease |
| title_sort | harnessing cd8 sup sup cd28 sup sup regulatory t cells as a tool to treat autoimmune disease |
| topic | CD8 Treg autoimmunity immunoregulation |
| url | https://www.mdpi.com/2073-4409/10/11/2973 |
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