Using Monoclonal Antibody Therapies for Multiple Sclerosis: A Review
Paul M Elsbernd, Jonathan L Carter Department of Neurology, Mayo Clinic, Scottsdale, AZ, USACorrespondence: Jonathan L CarterDepartment of Neurology, Mayo Clinic, 13400 East Shea Boulevard, Scottsdale, AZ, 85259, USATel +1-480-301-8100Fax +1-480-301-8451Email carter.jonathan@mayo.eduAbstract: Monocl...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2021-06-01
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| Series: | Biologics: Targets & Therapy |
| Subjects: | |
| Online Access: | https://www.dovepress.com/using-monoclonal-antibody-therapies-for-multiple-sclerosis-a-review-peer-reviewed-fulltext-article-BTT |
| _version_ | 1819042220613828608 |
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| author | Elsbernd PM Carter JL |
| author_facet | Elsbernd PM Carter JL |
| author_sort | Elsbernd PM |
| collection | DOAJ |
| description | Paul M Elsbernd, Jonathan L Carter Department of Neurology, Mayo Clinic, Scottsdale, AZ, USACorrespondence: Jonathan L CarterDepartment of Neurology, Mayo Clinic, 13400 East Shea Boulevard, Scottsdale, AZ, 85259, USATel +1-480-301-8100Fax +1-480-301-8451Email carter.jonathan@mayo.eduAbstract: Monoclonal antibody therapies have secured an important role in the therapeutic landscape for the treatment of both relapsing and progressive forms of multiple sclerosis due to their potent efficacy, convenient dosing schedules, and well-defined side effect profiles. Each therapy has unique risks and benefits associated with its specific mechanism of action which ultimately guides clinical decision-making for individual patients. This review will summarize the mechanisms of action, evidence leading to their approval, and clinically relevant considerations for each of the current monoclonal antibody therapies approved for the treatment of multiple sclerosis.Keywords: monoclonal antibodies, multiple sclerosis, relapsing, progressive, review |
| first_indexed | 2024-12-21T09:37:26Z |
| format | Article |
| id | doaj.art-0c91e8bc3c8248e58ce948176146391f |
| institution | Directory Open Access Journal |
| issn | 1177-5491 |
| language | English |
| last_indexed | 2024-12-21T09:37:26Z |
| publishDate | 2021-06-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Biologics: Targets & Therapy |
| spelling | doaj.art-0c91e8bc3c8248e58ce948176146391f2022-12-21T19:08:35ZengDove Medical PressBiologics: Targets & Therapy1177-54912021-06-01Volume 1525526366448Using Monoclonal Antibody Therapies for Multiple Sclerosis: A ReviewElsbernd PMCarter JLPaul M Elsbernd, Jonathan L Carter Department of Neurology, Mayo Clinic, Scottsdale, AZ, USACorrespondence: Jonathan L CarterDepartment of Neurology, Mayo Clinic, 13400 East Shea Boulevard, Scottsdale, AZ, 85259, USATel +1-480-301-8100Fax +1-480-301-8451Email carter.jonathan@mayo.eduAbstract: Monoclonal antibody therapies have secured an important role in the therapeutic landscape for the treatment of both relapsing and progressive forms of multiple sclerosis due to their potent efficacy, convenient dosing schedules, and well-defined side effect profiles. Each therapy has unique risks and benefits associated with its specific mechanism of action which ultimately guides clinical decision-making for individual patients. This review will summarize the mechanisms of action, evidence leading to their approval, and clinically relevant considerations for each of the current monoclonal antibody therapies approved for the treatment of multiple sclerosis.Keywords: monoclonal antibodies, multiple sclerosis, relapsing, progressive, reviewhttps://www.dovepress.com/using-monoclonal-antibody-therapies-for-multiple-sclerosis-a-review-peer-reviewed-fulltext-article-BTTmonoclonal antibodiesmultiple sclerosisrelapsingprogressivereview |
| spellingShingle | Elsbernd PM Carter JL Using Monoclonal Antibody Therapies for Multiple Sclerosis: A Review Biologics: Targets & Therapy monoclonal antibodies multiple sclerosis relapsing progressive review |
| title | Using Monoclonal Antibody Therapies for Multiple Sclerosis: A Review |
| title_full | Using Monoclonal Antibody Therapies for Multiple Sclerosis: A Review |
| title_fullStr | Using Monoclonal Antibody Therapies for Multiple Sclerosis: A Review |
| title_full_unstemmed | Using Monoclonal Antibody Therapies for Multiple Sclerosis: A Review |
| title_short | Using Monoclonal Antibody Therapies for Multiple Sclerosis: A Review |
| title_sort | using monoclonal antibody therapies for multiple sclerosis a review |
| topic | monoclonal antibodies multiple sclerosis relapsing progressive review |
| url | https://www.dovepress.com/using-monoclonal-antibody-therapies-for-multiple-sclerosis-a-review-peer-reviewed-fulltext-article-BTT |
| work_keys_str_mv | AT elsberndpm usingmonoclonalantibodytherapiesformultiplesclerosisareview AT carterjl usingmonoclonalantibodytherapiesformultiplesclerosisareview |