Vitamin B<sub>12b</sub> Enhances the Cytotoxicity of Diethyldithiocarbamate in a Synergistic Manner, Inducing the Paraptosis-Like Death of Human Larynx Carcinoma Cells

Vitamin B<sub>12b</sub> Enhances the Cytotoxicity of Diethyldithiocarbamate in a Synergistic Manner, Inducing the Paraptosis-Like Death of Human Larynx Carcinoma Cells

We have shown that hydroxycobalamin (vitamin B<sub>12b</sub>) increases the toxicity of diethyldithiocarbamate (DDC) to tumor cells by catalyzing the formation of disulfiram (DSF) oxi-derivatives. The purpose of this study was to elucidate the mechanism of tumor cell death induced by the...

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Những tác giả chính: Marina Solovieva, Yuri Shatalin, Roman Fadeev, Olga Krestinina, Yulia Baburina, Alexey Kruglov, Ekaterina Kharechkina, Margarita Kobyakova, Vadim Rogachevsky, Elena Shishkova, Vladimir Akatov
Định dạng: Bài viết
Ngôn ngữ:English
Được phát hành: MDPI AG 2020-01-01
Loạt:Biomolecules
Những chủ đề:
hydroxycobalamin
vitamin b<sub>12b</sub>
diethyldithiocarbamate
synergism
cytotoxicity
endoplasmic reticulum
er-stress
cytoplasm vacuolization
paraptosis-like cell death
Truy cập trực tuyến:https://www.mdpi.com/2218-273X/10/1/69

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https://www.mdpi.com/2218-273X/10/1/69

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