Single methyl groups can act as toggle switches to specify transmembrane Protein-protein interactions

Single methyl groups can act as toggle switches to specify transmembrane Protein-protein interactions

Transmembrane domains (TMDs) engage in protein-protein interactions that regulate many cellular processes, but the rules governing the specificity of these interactions are poorly understood. To discover these principles, we analyzed 26-residue model transmembrane proteins consisting exclusively of...

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Bibliographic Details
Main Authors: Li He, Helena Steinocher, Ashish Shelar, Emily B Cohen, Erin N Heim, Birthe B Kragelund, Gevorg Grigoryan, Daniel DiMaio
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-09-01
Series:eLife
Subjects:
transmembrane proteins
protein-protein interacctions
traptamers
membrane
NMR
molecular dynamics
Online Access:https://elifesciences.org/articles/27701

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