Ten things you should know about transposable elements
Abstract Transposable elements (TEs) are major components of eukaryotic genomes. However, the extent of their impact on genome evolution, function, and disease remain a matter of intense interrogation. The rise of genomics and large-scale functional assays has shed new light on the multi-faceted act...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-11-01
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| Series: | Genome Biology |
| Online Access: | http://link.springer.com/article/10.1186/s13059-018-1577-z |
| _version_ | 1831686079634210816 |
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| author | Guillaume Bourque Kathleen H. Burns Mary Gehring Vera Gorbunova Andrei Seluanov Molly Hammell Michaël Imbeault Zsuzsanna Izsvák Henry L. Levin Todd S. Macfarlan Dixie L. Mager Cédric Feschotte |
| author_facet | Guillaume Bourque Kathleen H. Burns Mary Gehring Vera Gorbunova Andrei Seluanov Molly Hammell Michaël Imbeault Zsuzsanna Izsvák Henry L. Levin Todd S. Macfarlan Dixie L. Mager Cédric Feschotte |
| author_sort | Guillaume Bourque |
| collection | DOAJ |
| description | Abstract Transposable elements (TEs) are major components of eukaryotic genomes. However, the extent of their impact on genome evolution, function, and disease remain a matter of intense interrogation. The rise of genomics and large-scale functional assays has shed new light on the multi-faceted activities of TEs and implies that they should no longer be marginalized. Here, we introduce the fundamental properties of TEs and their complex interactions with their cellular environment, which are crucial to understanding their impact and manifold consequences for organismal biology. While we draw examples primarily from mammalian systems, the core concepts outlined here are relevant to a broad range of organisms. |
| first_indexed | 2024-12-20T08:32:56Z |
| format | Article |
| id | doaj.art-0c9449d64f8a4833a29a40cd990696c0 |
| institution | Directory Open Access Journal |
| issn | 1474-760X |
| language | English |
| last_indexed | 2024-12-20T08:32:56Z |
| publishDate | 2018-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Genome Biology |
| spelling | doaj.art-0c9449d64f8a4833a29a40cd990696c02022-12-21T19:46:39ZengBMCGenome Biology1474-760X2018-11-0119111210.1186/s13059-018-1577-zTen things you should know about transposable elementsGuillaume Bourque0Kathleen H. Burns1Mary Gehring2Vera Gorbunova3Andrei Seluanov4Molly Hammell5Michaël Imbeault6Zsuzsanna Izsvák7Henry L. Levin8Todd S. Macfarlan9Dixie L. Mager10Cédric Feschotte11Department of Human Genetics, McGill UniversityDepartment of Pathology, Johns Hopkins University School of MedicineWhitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of TechnologyDepartment of Biology, University of RochesterDepartment of Biology, University of RochesterCold Spring Harbor LaboratoryDepartment of Genetics, University of CambridgeMax Delbrück Center for Molecular Medicine in the Helmholtz AssociationThe Eunice Kennedy Shriver National Institute of Child Health and Human Development, The National Institutes of HealthThe Eunice Kennedy Shriver National Institute of Child Health and Human Development, The National Institutes of HealthTerry Fox Laboratory, British Columbia Cancer Agency and Department of Medical Genetics, University of BCDepartment of Molecular Biology and Genetics, Cornell UniversityAbstract Transposable elements (TEs) are major components of eukaryotic genomes. However, the extent of their impact on genome evolution, function, and disease remain a matter of intense interrogation. The rise of genomics and large-scale functional assays has shed new light on the multi-faceted activities of TEs and implies that they should no longer be marginalized. Here, we introduce the fundamental properties of TEs and their complex interactions with their cellular environment, which are crucial to understanding their impact and manifold consequences for organismal biology. While we draw examples primarily from mammalian systems, the core concepts outlined here are relevant to a broad range of organisms.http://link.springer.com/article/10.1186/s13059-018-1577-z |
| spellingShingle | Guillaume Bourque Kathleen H. Burns Mary Gehring Vera Gorbunova Andrei Seluanov Molly Hammell Michaël Imbeault Zsuzsanna Izsvák Henry L. Levin Todd S. Macfarlan Dixie L. Mager Cédric Feschotte Ten things you should know about transposable elements Genome Biology |
| title | Ten things you should know about transposable elements |
| title_full | Ten things you should know about transposable elements |
| title_fullStr | Ten things you should know about transposable elements |
| title_full_unstemmed | Ten things you should know about transposable elements |
| title_short | Ten things you should know about transposable elements |
| title_sort | ten things you should know about transposable elements |
| url | http://link.springer.com/article/10.1186/s13059-018-1577-z |
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