Engineering Escherichia coli for increased Und-P availability leads to material improvements in glycan expression technology

Engineering Escherichia coli for increased Und-P availability leads to material improvements in glycan expression technology

Abstract Background Bacterial surface glycans are assembled by glycosyltransferases (GTs) that transfer sugar monomers to long-chained lipid carriers. Most bacteria employ the 55-carbon chain undecaprenyl phosphate (Und-P) to scaffold glycan assembly. The amount of Und-P available for glycan synthes...

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Bibliographic Details
Main Authors: Emily J. Kay, Manoj K. Dooda, Joseph C. Bryant, Amanda J. Reid, Brendan W. Wren, Jerry M. Troutman, Matthew A. Jorgenson
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Microbial Cell Factories
Subjects:
Undecaprenyl phosphate
Polysaccharide
Capsule
Glycoengineering
Online Access:https://doi.org/10.1186/s12934-024-02339-8

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