Identification of Important Effector Proteins in the FOXJ1 Transcriptional Network Associated With Ciliogenesis and Ciliary Function

Identification of Important Effector Proteins in the FOXJ1 Transcriptional Network Associated With Ciliogenesis and Ciliary Function

Developmental defects in motile cilia, arising from genetic abnormalities in one or more ciliary genes, can lead to a common ciliopathy known as primary ciliary dyskinesia (PCD). Functional studies in model organisms undertaken to understand PCD or cilia biogenesis have identified 100s of genes regu...

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Bibliographic Details
Main Authors: Ishita Mukherjee, Sudipto Roy, Saikat Chakrabarti
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Genetics
Subjects:
FOXJ1
motile cilia
primary ciliary dyskinesia
ciliopathy
transcriptional network
protein–protein interaction
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.00023/full

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