Focusing of Microcrystals and Liquid Condensates in Acoustofluidics
Manipulation of high-density materials, such as crystals and liquid condensates, is of great importance for many applications, including serial crystallography, structural and molecular biology, chemistry, and medicine. In this work, we describe an acoustic technique to focus and harvest flowing cry...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-02-01
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| Series: | Crystals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4352/9/3/120 |
| _version_ | 1798043669318598656 |
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| author | Pierre Gelin Joris Van Lindt Anna Bratek-Skicki Sander Stroobants Marzena Krzek Iwona Ziemecka Peter Tompa Wim De Malsche Dominique Maes |
| author_facet | Pierre Gelin Joris Van Lindt Anna Bratek-Skicki Sander Stroobants Marzena Krzek Iwona Ziemecka Peter Tompa Wim De Malsche Dominique Maes |
| author_sort | Pierre Gelin |
| collection | DOAJ |
| description | Manipulation of high-density materials, such as crystals and liquid condensates, is of great importance for many applications, including serial crystallography, structural and molecular biology, chemistry, and medicine. In this work, we describe an acoustic technique to focus and harvest flowing crystals and liquid condensates. Moreover, we show, based on numerical simulations, that the acoustic waves can be used for size-based particle (crystals, droplets, etc.) separation. This is an essential technological step in biological research, medical applications, and industrial processes. The presented technology offers high precision, biocompatibility, ease of use and additionally, is non-invasive and inexpensive. With the recent advent of X-ray Free Electron Laser (XFEL) technology and the associated enormous importance of a thin jet of crystals, this technology might pave the way to a novel type of XFEL injector. |
| first_indexed | 2024-04-11T22:52:20Z |
| format | Article |
| id | doaj.art-0c95257a8c174edb893810d2e5d254f8 |
| institution | Directory Open Access Journal |
| issn | 2073-4352 |
| language | English |
| last_indexed | 2024-04-11T22:52:20Z |
| publishDate | 2019-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Crystals |
| spelling | doaj.art-0c95257a8c174edb893810d2e5d254f82022-12-22T03:58:33ZengMDPI AGCrystals2073-43522019-02-019312010.3390/cryst9030120cryst9030120Focusing of Microcrystals and Liquid Condensates in AcoustofluidicsPierre Gelin0Joris Van Lindt1Anna Bratek-Skicki2Sander Stroobants3Marzena Krzek4Iwona Ziemecka5Peter Tompa6Wim De Malsche7Dominique Maes8Department of Chemical Engineering, µFlow Group, Vrije Universiteit Brussel, Brussels 1050, BelgiumStructural Biology Brussels, Vrije Universiteit Brussel, Brussels 1050, BelgiumStructural Biology Brussels, Vrije Universiteit Brussel, Brussels 1050, BelgiumStructural Biology Brussels, Vrije Universiteit Brussel, Brussels 1050, BelgiumStructural Biology Brussels, Vrije Universiteit Brussel, Brussels 1050, BelgiumDepartment of Chemical Engineering, µFlow Group, Vrije Universiteit Brussel, Brussels 1050, BelgiumStructural Biology Brussels, Vrije Universiteit Brussel, Brussels 1050, BelgiumDepartment of Chemical Engineering, µFlow Group, Vrije Universiteit Brussel, Brussels 1050, BelgiumStructural Biology Brussels, Vrije Universiteit Brussel, Brussels 1050, BelgiumManipulation of high-density materials, such as crystals and liquid condensates, is of great importance for many applications, including serial crystallography, structural and molecular biology, chemistry, and medicine. In this work, we describe an acoustic technique to focus and harvest flowing crystals and liquid condensates. Moreover, we show, based on numerical simulations, that the acoustic waves can be used for size-based particle (crystals, droplets, etc.) separation. This is an essential technological step in biological research, medical applications, and industrial processes. The presented technology offers high precision, biocompatibility, ease of use and additionally, is non-invasive and inexpensive. With the recent advent of X-ray Free Electron Laser (XFEL) technology and the associated enormous importance of a thin jet of crystals, this technology might pave the way to a novel type of XFEL injector.https://www.mdpi.com/2073-4352/9/3/120microcrystalsliquid-liquid phase separationmicrofluidicsacoustic radiationparticle separationfocusingserial crystallographyfree electron lasercrystal harvesting |
| spellingShingle | Pierre Gelin Joris Van Lindt Anna Bratek-Skicki Sander Stroobants Marzena Krzek Iwona Ziemecka Peter Tompa Wim De Malsche Dominique Maes Focusing of Microcrystals and Liquid Condensates in Acoustofluidics Crystals microcrystals liquid-liquid phase separation microfluidics acoustic radiation particle separation focusing serial crystallography free electron laser crystal harvesting |
| title | Focusing of Microcrystals and Liquid Condensates in Acoustofluidics |
| title_full | Focusing of Microcrystals and Liquid Condensates in Acoustofluidics |
| title_fullStr | Focusing of Microcrystals and Liquid Condensates in Acoustofluidics |
| title_full_unstemmed | Focusing of Microcrystals and Liquid Condensates in Acoustofluidics |
| title_short | Focusing of Microcrystals and Liquid Condensates in Acoustofluidics |
| title_sort | focusing of microcrystals and liquid condensates in acoustofluidics |
| topic | microcrystals liquid-liquid phase separation microfluidics acoustic radiation particle separation focusing serial crystallography free electron laser crystal harvesting |
| url | https://www.mdpi.com/2073-4352/9/3/120 |
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