A Case of Meningococcal and HSV-2 Meningitis in a Patient Being Treated with Ustekinumab for Pityriasis Rubra Pilaris
Pityriasis rubra pilaris (PRP) is a rare chronic inflammatory papulosquamous dermatosis affecting both adults and children. Six subtypes of PRP have been described. Recently, the management of PRP with biologic immunosuppressive agents regularly used in psoriasis has been supported by several case r...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SMC MEDIA SRL
2020-05-01
|
| Series: | European Journal of Case Reports in Internal Medicine |
| Subjects: | |
| Online Access: | https://www.ejcrim.com/index.php/EJCRIM/article/view/1615 |
| _version_ | 1818500515606036480 |
|---|---|
| author | Charalampos I Kalogeropoulos Konstantinos Papathanasiou Ismini Tsagkaraki Georgios Giannopoulos Aristotelis Bamias Eleni Boutati |
| author_facet | Charalampos I Kalogeropoulos Konstantinos Papathanasiou Ismini Tsagkaraki Georgios Giannopoulos Aristotelis Bamias Eleni Boutati |
| author_sort | Charalampos I Kalogeropoulos |
| collection | DOAJ |
| description | Pityriasis rubra pilaris (PRP) is a rare chronic inflammatory papulosquamous dermatosis affecting both adults and children. Six subtypes of PRP have been described. Recently, the management of PRP with biologic immunosuppressive agents regularly used in psoriasis has been supported by several case reports and series. Ustekinumab is an anti-IL12/23 IgG1 kappa human monoclonal antibody. It has been approved for the treatment of Crohn’s disease, plaque psoriasis, psoriatic arthritis and ulcerative colitis. It has also been reported to be effective as an off-label treatment for PRP. Current data are equivocal regarding infectious disease risk with ustekinumab administration. We describe a case of meningococcal and HSV-2 infection of the central nervous system in a patient being treated with ustekinumab for PRP. |
| first_indexed | 2024-12-10T20:43:47Z |
| format | Article |
| id | doaj.art-0c97f5ef40e1410ab4fa14dfee6e0311 |
| institution | Directory Open Access Journal |
| issn | 2284-2594 |
| language | English |
| last_indexed | 2024-12-10T20:43:47Z |
| publishDate | 2020-05-01 |
| publisher | SMC MEDIA SRL |
| record_format | Article |
| series | European Journal of Case Reports in Internal Medicine |
| spelling | doaj.art-0c97f5ef40e1410ab4fa14dfee6e03112022-12-22T01:34:18ZengSMC MEDIA SRLEuropean Journal of Case Reports in Internal Medicine2284-25942020-05-0110.12890/2020_0016151257A Case of Meningococcal and HSV-2 Meningitis in a Patient Being Treated with Ustekinumab for Pityriasis Rubra PilarisCharalampos I Kalogeropoulos0Konstantinos Papathanasiou1Ismini Tsagkaraki2Georgios Giannopoulos3Aristotelis Bamias4Eleni Boutati5Second Propaedeutic Department of Internal Medicine and Research Institute, University General Hospital Attikon, National and Kapodistrian University of Athens, Athens, GreeceSecond Propaedeutic Department of Internal Medicine and Research Institute, University General Hospital Attikon, National and Kapodistrian University of Athens, Athens, GreeceSecond Propaedeutic Department of Internal Medicine and Research Institute, University General Hospital Attikon, National and Kapodistrian University of Athens, Athens, GreeceSecond Propaedeutic Department of Internal Medicine and Research Institute, University General Hospital Attikon, National and Kapodistrian University of Athens, Athens, GreeceSecond Propaedeutic Department of Internal Medicine and Research Institute, University General Hospital Attikon, National and Kapodistrian University of Athens, Athens, GreeceSecond Propaedeutic Department of Internal Medicine and Research Institute, University General Hospital Attikon, National and Kapodistrian University of Athens, Athens, GreecePityriasis rubra pilaris (PRP) is a rare chronic inflammatory papulosquamous dermatosis affecting both adults and children. Six subtypes of PRP have been described. Recently, the management of PRP with biologic immunosuppressive agents regularly used in psoriasis has been supported by several case reports and series. Ustekinumab is an anti-IL12/23 IgG1 kappa human monoclonal antibody. It has been approved for the treatment of Crohn’s disease, plaque psoriasis, psoriatic arthritis and ulcerative colitis. It has also been reported to be effective as an off-label treatment for PRP. Current data are equivocal regarding infectious disease risk with ustekinumab administration. We describe a case of meningococcal and HSV-2 infection of the central nervous system in a patient being treated with ustekinumab for PRP.https://www.ejcrim.com/index.php/EJCRIM/article/view/1615pityriasis rubra pilarisustekinumabmeningococcal meningitis |
| spellingShingle | Charalampos I Kalogeropoulos Konstantinos Papathanasiou Ismini Tsagkaraki Georgios Giannopoulos Aristotelis Bamias Eleni Boutati A Case of Meningococcal and HSV-2 Meningitis in a Patient Being Treated with Ustekinumab for Pityriasis Rubra Pilaris European Journal of Case Reports in Internal Medicine pityriasis rubra pilaris ustekinumab meningococcal meningitis |
| title | A Case of Meningococcal and HSV-2 Meningitis in a Patient Being Treated with Ustekinumab for Pityriasis Rubra Pilaris |
| title_full | A Case of Meningococcal and HSV-2 Meningitis in a Patient Being Treated with Ustekinumab for Pityriasis Rubra Pilaris |
| title_fullStr | A Case of Meningococcal and HSV-2 Meningitis in a Patient Being Treated with Ustekinumab for Pityriasis Rubra Pilaris |
| title_full_unstemmed | A Case of Meningococcal and HSV-2 Meningitis in a Patient Being Treated with Ustekinumab for Pityriasis Rubra Pilaris |
| title_short | A Case of Meningococcal and HSV-2 Meningitis in a Patient Being Treated with Ustekinumab for Pityriasis Rubra Pilaris |
| title_sort | case of meningococcal and hsv 2 meningitis in a patient being treated with ustekinumab for pityriasis rubra pilaris |
| topic | pityriasis rubra pilaris ustekinumab meningococcal meningitis |
| url | https://www.ejcrim.com/index.php/EJCRIM/article/view/1615 |
| work_keys_str_mv | AT charalamposikalogeropoulos acaseofmeningococcalandhsv2meningitisinapatientbeingtreatedwithustekinumabforpityriasisrubrapilaris AT konstantinospapathanasiou acaseofmeningococcalandhsv2meningitisinapatientbeingtreatedwithustekinumabforpityriasisrubrapilaris AT isminitsagkaraki acaseofmeningococcalandhsv2meningitisinapatientbeingtreatedwithustekinumabforpityriasisrubrapilaris AT georgiosgiannopoulos acaseofmeningococcalandhsv2meningitisinapatientbeingtreatedwithustekinumabforpityriasisrubrapilaris AT aristotelisbamias acaseofmeningococcalandhsv2meningitisinapatientbeingtreatedwithustekinumabforpityriasisrubrapilaris AT eleniboutati acaseofmeningococcalandhsv2meningitisinapatientbeingtreatedwithustekinumabforpityriasisrubrapilaris AT charalamposikalogeropoulos caseofmeningococcalandhsv2meningitisinapatientbeingtreatedwithustekinumabforpityriasisrubrapilaris AT konstantinospapathanasiou caseofmeningococcalandhsv2meningitisinapatientbeingtreatedwithustekinumabforpityriasisrubrapilaris AT isminitsagkaraki caseofmeningococcalandhsv2meningitisinapatientbeingtreatedwithustekinumabforpityriasisrubrapilaris AT georgiosgiannopoulos caseofmeningococcalandhsv2meningitisinapatientbeingtreatedwithustekinumabforpityriasisrubrapilaris AT aristotelisbamias caseofmeningococcalandhsv2meningitisinapatientbeingtreatedwithustekinumabforpityriasisrubrapilaris AT eleniboutati caseofmeningococcalandhsv2meningitisinapatientbeingtreatedwithustekinumabforpityriasisrubrapilaris |