Inflammatory Myofibroblastic Tumour –An Unusual Tumour with Intermediate Malignant Potential- Report of Three Cases
Inflammatory Myofibroblastic Tumour (IMT) is a rare mesenchymal neoplasm of borderline malignancy. It is characterised by proliferation of myofibroblasts and fibroblasts with variable amount of inflammatory infiltrate. About 50-60% of the cases show Anaplastic Lymphoma Kinase (ALK) rearrangements....
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2017-12-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/11008/32212_F(AP)%20PF1(BT%20%20PB%20%20SG%20%20VG_PFA(MJ_AnG)pdf.pdf |
| Summary: | Inflammatory Myofibroblastic Tumour (IMT) is a rare mesenchymal neoplasm of borderline malignancy. It is characterised
by proliferation of myofibroblasts and fibroblasts with variable amount of inflammatory infiltrate. About 50-60% of the cases
show Anaplastic Lymphoma Kinase (ALK) rearrangements. The recurrence rate and metastasis depends on the anatomic
site, resectability, size and presence of ALK rearrangements. In this case series, we are presenting three cases diagnosed as
IMT. All the patients were elderly. Sites included abdomen, subcutaneous tissue over scapula and orbit. Scapular lesion
presented as recurrence in six months after first excision. All three cases were ALK negative. IMTs that occur in elderly persons
can mimic malignancy. Surgical excision is the treatment of choice. Diagnosis depends on histopathological features and
immunohistochemical examination. Correct histological diagnosis is crucial for further management. Chance of recurrence and
metastasis is more in abdominopelvic location, large size and ALK negativity. This case series aims to create awareness of the
non-specific presentation of this tumour and need of follow up as this tumour may recur in a very short interval. |
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| ISSN: | 2249-782X 0973-709X |