The Role of IgM-Enriched Immunoglobulin (Pentaglobin) in Septic Patients with Hematological Disease
Background: Patients with hematological disease are 15 times more likely to develop sepsis than the general population. The patient with hematological disease and, mainly, those undergoing hematopoietic stem cell transplantation (HSCT), develop a severe secondary humoral immunodeficiency, with low s...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tehran University of Medical Sciences
2021-04-01
|
| Series: | International Journal of Hematology-Oncology and Stem Cell Research |
| Subjects: | |
| Online Access: | https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/1276 |
| _version_ | 1827935713920811008 |
|---|---|
| author | Pedro Amoedo Fernandes Flávia Tobaldini Russo Lucas Augusto Monetta da Silva Lafayete William Ferreira Ramos Aline de Almeida Simões Larissa Yukari Okada Jamilla Neves Cavalcante Maricy Almeida Viol Ferreira Lopes Maria Cristina Martins de Almeida Macedo Roberto Luiz da Silva |
| author_facet | Pedro Amoedo Fernandes Flávia Tobaldini Russo Lucas Augusto Monetta da Silva Lafayete William Ferreira Ramos Aline de Almeida Simões Larissa Yukari Okada Jamilla Neves Cavalcante Maricy Almeida Viol Ferreira Lopes Maria Cristina Martins de Almeida Macedo Roberto Luiz da Silva |
| author_sort | Pedro Amoedo Fernandes |
| collection | DOAJ |
| description | Background: Patients with hematological disease are 15 times more likely to develop sepsis than the general population. The patient with hematological disease and, mainly, those undergoing hematopoietic stem cell transplantation (HSCT), develop a severe secondary humoral immunodeficiency, with low serum levels of IgM, which may take more than a year to be restored.
Materials and Methods: This is a retrospective, controlled and observational study that analyzed 51 patients with underlying hematological disease, who were diagnosed with sepsis or septic shock during the study period, to evaluate whether IgM-rich Ig replacement decreases the 30-day mortality.
Results: Of the 51 patients, 35 patients received IgM-rich immunoglobulin (group A) and 16 (31%) received conventional therapy. Eleven (69%) patients in the control group were alive after 30 days compared to 11 (34%) patients in the intervention group, p= 0.013.
Conclusion: There are no apparent benefits in the use of IgM-rich immunoglobulin in septic patients with hematological disease. |
| first_indexed | 2024-03-13T07:58:47Z |
| format | Article |
| id | doaj.art-0c982e4be69d4f90a3e917ac3160ed0c |
| institution | Directory Open Access Journal |
| issn | 2008-2207 |
| language | English |
| last_indexed | 2024-03-13T07:58:47Z |
| publishDate | 2021-04-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | International Journal of Hematology-Oncology and Stem Cell Research |
| spelling | doaj.art-0c982e4be69d4f90a3e917ac3160ed0c2023-06-02T00:03:29ZengTehran University of Medical SciencesInternational Journal of Hematology-Oncology and Stem Cell Research2008-22072021-04-0115210.18502/ijhoscr.v15i2.60411276The Role of IgM-Enriched Immunoglobulin (Pentaglobin) in Septic Patients with Hematological DiseasePedro Amoedo Fernandes0Flávia Tobaldini Russo1Lucas Augusto Monetta da Silva2Lafayete William Ferreira Ramos3Aline de Almeida Simões4Larissa Yukari Okada5Jamilla Neves Cavalcante6Maricy Almeida Viol Ferreira Lopes7Maria Cristina Martins de Almeida Macedo8Roberto Luiz da Silva9Instituto Brasileiro de Controle do Câncer (IBCC),São Paulo, SP, BrasilInstituto Brasileiro de Controle do Câncer (IBCC),São Paulo, SP, BrasilFaculdade de Ciências Médicas Santa Casa de São Paulo, São Paulo, SP, BrasilInstituto Brasileiro de Controle do Câncer (IBCC),São Paulo, SP, BrasilInstituto Brasileiro de Controle do Câncer (IBCC),São Paulo, SP, BrasilInstituto Brasileiro de Controle do Câncer (IBCC),São Paulo, SP, BrasilInstituto Brasileiro de Controle do Câncer (IBCC),São Paulo, SP, BrasilInstituto Brasileiro de Controle do Câncer (IBCC),São Paulo, SP, BrasilInstituto Brasileiro de Controle do Câncer (IBCC),São Paulo, SP, BrasilInstituto Brasileiro de Controle do Câncer (IBCC),São Paulo, SP, BrasilBackground: Patients with hematological disease are 15 times more likely to develop sepsis than the general population. The patient with hematological disease and, mainly, those undergoing hematopoietic stem cell transplantation (HSCT), develop a severe secondary humoral immunodeficiency, with low serum levels of IgM, which may take more than a year to be restored. Materials and Methods: This is a retrospective, controlled and observational study that analyzed 51 patients with underlying hematological disease, who were diagnosed with sepsis or septic shock during the study period, to evaluate whether IgM-rich Ig replacement decreases the 30-day mortality. Results: Of the 51 patients, 35 patients received IgM-rich immunoglobulin (group A) and 16 (31%) received conventional therapy. Eleven (69%) patients in the control group were alive after 30 days compared to 11 (34%) patients in the intervention group, p= 0.013. Conclusion: There are no apparent benefits in the use of IgM-rich immunoglobulin in septic patients with hematological disease.https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/1276Pentaglobin; Sepsis; Hematological disease |
| spellingShingle | Pedro Amoedo Fernandes Flávia Tobaldini Russo Lucas Augusto Monetta da Silva Lafayete William Ferreira Ramos Aline de Almeida Simões Larissa Yukari Okada Jamilla Neves Cavalcante Maricy Almeida Viol Ferreira Lopes Maria Cristina Martins de Almeida Macedo Roberto Luiz da Silva The Role of IgM-Enriched Immunoglobulin (Pentaglobin) in Septic Patients with Hematological Disease International Journal of Hematology-Oncology and Stem Cell Research Pentaglobin; Sepsis; Hematological disease |
| title | The Role of IgM-Enriched Immunoglobulin (Pentaglobin) in Septic Patients with Hematological Disease |
| title_full | The Role of IgM-Enriched Immunoglobulin (Pentaglobin) in Septic Patients with Hematological Disease |
| title_fullStr | The Role of IgM-Enriched Immunoglobulin (Pentaglobin) in Septic Patients with Hematological Disease |
| title_full_unstemmed | The Role of IgM-Enriched Immunoglobulin (Pentaglobin) in Septic Patients with Hematological Disease |
| title_short | The Role of IgM-Enriched Immunoglobulin (Pentaglobin) in Septic Patients with Hematological Disease |
| title_sort | role of igm enriched immunoglobulin pentaglobin in septic patients with hematological disease |
| topic | Pentaglobin; Sepsis; Hematological disease |
| url | https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/1276 |
| work_keys_str_mv | AT pedroamoedofernandes theroleofigmenrichedimmunoglobulinpentaglobininsepticpatientswithhematologicaldisease AT flaviatobaldinirusso theroleofigmenrichedimmunoglobulinpentaglobininsepticpatientswithhematologicaldisease AT lucasaugustomonettadasilva theroleofigmenrichedimmunoglobulinpentaglobininsepticpatientswithhematologicaldisease AT lafayetewilliamferreiraramos theroleofigmenrichedimmunoglobulinpentaglobininsepticpatientswithhematologicaldisease AT alinedealmeidasimoes theroleofigmenrichedimmunoglobulinpentaglobininsepticpatientswithhematologicaldisease AT larissayukariokada theroleofigmenrichedimmunoglobulinpentaglobininsepticpatientswithhematologicaldisease AT jamillanevescavalcante theroleofigmenrichedimmunoglobulinpentaglobininsepticpatientswithhematologicaldisease AT maricyalmeidaviolferreiralopes theroleofigmenrichedimmunoglobulinpentaglobininsepticpatientswithhematologicaldisease AT mariacristinamartinsdealmeidamacedo theroleofigmenrichedimmunoglobulinpentaglobininsepticpatientswithhematologicaldisease AT robertoluizdasilva theroleofigmenrichedimmunoglobulinpentaglobininsepticpatientswithhematologicaldisease AT pedroamoedofernandes roleofigmenrichedimmunoglobulinpentaglobininsepticpatientswithhematologicaldisease AT flaviatobaldinirusso roleofigmenrichedimmunoglobulinpentaglobininsepticpatientswithhematologicaldisease AT lucasaugustomonettadasilva roleofigmenrichedimmunoglobulinpentaglobininsepticpatientswithhematologicaldisease AT lafayetewilliamferreiraramos roleofigmenrichedimmunoglobulinpentaglobininsepticpatientswithhematologicaldisease AT alinedealmeidasimoes roleofigmenrichedimmunoglobulinpentaglobininsepticpatientswithhematologicaldisease AT larissayukariokada roleofigmenrichedimmunoglobulinpentaglobininsepticpatientswithhematologicaldisease AT jamillanevescavalcante roleofigmenrichedimmunoglobulinpentaglobininsepticpatientswithhematologicaldisease AT maricyalmeidaviolferreiralopes roleofigmenrichedimmunoglobulinpentaglobininsepticpatientswithhematologicaldisease AT mariacristinamartinsdealmeidamacedo roleofigmenrichedimmunoglobulinpentaglobininsepticpatientswithhematologicaldisease AT robertoluizdasilva roleofigmenrichedimmunoglobulinpentaglobininsepticpatientswithhematologicaldisease |