PSEN1 E280A Cholinergic-like Neurons and Cerebral Spheroids Derived from Mesenchymal Stromal Cells and from Induced Pluripotent Stem Cells Are Neuropathologically Equivalent

PSEN1 E280A Cholinergic-like Neurons and Cerebral Spheroids Derived from Mesenchymal Stromal Cells and from Induced Pluripotent Stem Cells Are Neuropathologically Equivalent

Alzheimer’s disease (AD) is a chronic neurological condition characterized by the severe loss of cholinergic neurons. Currently, the incomplete understanding of the loss of neurons has prevented curative treatments for familial AD (FAD). Therefore, modeling FAD in vitro is essential for studying cho...

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Bibliographic Details
Main Authors: Miguel Mendivil-Perez, Carlos Velez-Pardo, Francisco Lopera, Kenneth S. Kosik, Marlene Jimenez-Del-Rio
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:International Journal of Molecular Sciences
Subjects:
Alzheimer
apoptosis
E280a
iPSCs
presenilin
mutant
Online Access:https://www.mdpi.com/1422-0067/24/10/8957

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