USE OF MULTIPARAMETER ANALYSIS OF LABORATORY BIOMARKERS TO ASSESS RHEUMATOID ARTHRITIS ACTIVITY
The key component in the management of patients with rheumatoid arthritis (RA) is regular control of RA activity. The quantitative assessment of a patient’s status allows the development of standardized indications for anti-rheumatic therapy.Objective: to identify the laboratory biomarkers able to r...
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| Format: | Article |
| Language: | Russian |
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IMA PRESS LLC
2016-02-01
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| Series: | Научно-практическая ревматология |
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| Online Access: | https://rsp.mediar-press.net/rsp/article/view/2148 |
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| author | A. A. Novikov E. N. Aleksandrova A. N. Gerasimov D. E. Karateev T. V. Popkova E. L. Luchikhina E. L. Nasonov |
| author_facet | A. A. Novikov E. N. Aleksandrova A. N. Gerasimov D. E. Karateev T. V. Popkova E. L. Luchikhina E. L. Nasonov |
| author_sort | A. A. Novikov |
| collection | DOAJ |
| description | The key component in the management of patients with rheumatoid arthritis (RA) is regular control of RA activity. The quantitative assessment of a patient’s status allows the development of standardized indications for anti-rheumatic therapy.Objective: to identify the laboratory biomarkers able to reflect RA activity.Subjects and methods. Fifty-eight patients with RA and 30 age- and sex-matched healthy donors were examined. The patients were divided into high/moderate and mild disease activity groups according to DAS28. The serum concentrations of 30 biomarkers were measured using immunonephelometric assay, enzyme immunoassay, and xMAP technology.Results and discussion. Multivariate analysis could identify the factors mostly related to high/moderate RA activity according to DAS28, such as fibroblast growth factor-2, monocyte chemoattractant protein-1, interleukins (IL) 1α, 6, and 15, and tumor necrosis factor-α and could create a prognostic model for RA activity assessment. ROC analysis has shown that this model has excellent diagnostic efficiency in differentiating high/moderate versus low RA activity.Conclusion. To create a subjective assessment-independent immunological multiparameter index of greater diagnostic accuracy than the laboratory parameters routinely used in clinical practice may be a qualitatively new step in assessing and monitoring RA activity. |
| first_indexed | 2024-04-09T22:24:46Z |
| format | Article |
| id | doaj.art-0c9b97dfbfb84505a321d3a803af0e4f |
| institution | Directory Open Access Journal |
| issn | 1995-4484 1995-4492 |
| language | Russian |
| last_indexed | 2024-04-09T22:24:46Z |
| publishDate | 2016-02-01 |
| publisher | IMA PRESS LLC |
| record_format | Article |
| series | Научно-практическая ревматология |
| spelling | doaj.art-0c9b97dfbfb84505a321d3a803af0e4f2023-03-22T13:45:50ZrusIMA PRESS LLCНаучно-практическая ревматология1995-44841995-44922016-02-0153659159510.14412/1995-4484-2015-591-5952028USE OF MULTIPARAMETER ANALYSIS OF LABORATORY BIOMARKERS TO ASSESS RHEUMATOID ARTHRITIS ACTIVITYA. A. Novikov0E. N. Aleksandrova1A. N. Gerasimov2D. E. Karateev3T. V. Popkova4E. L. Luchikhina5E. L. Nasonov6V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia; 34A, Kashirskoe Shosse, Moscow 115522V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia; 34A, Kashirskoe Shosse, Moscow 115522I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia 8, Trubetskaya St., Build. 2, Moscow 119991V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia; 34A, Kashirskoe Shosse, Moscow 115522V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia; 34A, Kashirskoe Shosse, Moscow 115522V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia; 34A, Kashirskoe Shosse, Moscow 115522V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia; 34A, Kashirskoe Shosse, Moscow 115522 I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia 8, Trubetskaya St., Build. 2, Moscow 119991The key component in the management of patients with rheumatoid arthritis (RA) is regular control of RA activity. The quantitative assessment of a patient’s status allows the development of standardized indications for anti-rheumatic therapy.Objective: to identify the laboratory biomarkers able to reflect RA activity.Subjects and methods. Fifty-eight patients with RA and 30 age- and sex-matched healthy donors were examined. The patients were divided into high/moderate and mild disease activity groups according to DAS28. The serum concentrations of 30 biomarkers were measured using immunonephelometric assay, enzyme immunoassay, and xMAP technology.Results and discussion. Multivariate analysis could identify the factors mostly related to high/moderate RA activity according to DAS28, such as fibroblast growth factor-2, monocyte chemoattractant protein-1, interleukins (IL) 1α, 6, and 15, and tumor necrosis factor-α and could create a prognostic model for RA activity assessment. ROC analysis has shown that this model has excellent diagnostic efficiency in differentiating high/moderate versus low RA activity.Conclusion. To create a subjective assessment-independent immunological multiparameter index of greater diagnostic accuracy than the laboratory parameters routinely used in clinical practice may be a qualitatively new step in assessing and monitoring RA activity.https://rsp.mediar-press.net/rsp/article/view/2148rheumatoid arthritisbiomarkers, multiparameter analysis |
| spellingShingle | A. A. Novikov E. N. Aleksandrova A. N. Gerasimov D. E. Karateev T. V. Popkova E. L. Luchikhina E. L. Nasonov USE OF MULTIPARAMETER ANALYSIS OF LABORATORY BIOMARKERS TO ASSESS RHEUMATOID ARTHRITIS ACTIVITY Научно-практическая ревматология rheumatoid arthritis biomarkers, multiparameter analysis |
| title | USE OF MULTIPARAMETER ANALYSIS OF LABORATORY BIOMARKERS TO ASSESS RHEUMATOID ARTHRITIS ACTIVITY |
| title_full | USE OF MULTIPARAMETER ANALYSIS OF LABORATORY BIOMARKERS TO ASSESS RHEUMATOID ARTHRITIS ACTIVITY |
| title_fullStr | USE OF MULTIPARAMETER ANALYSIS OF LABORATORY BIOMARKERS TO ASSESS RHEUMATOID ARTHRITIS ACTIVITY |
| title_full_unstemmed | USE OF MULTIPARAMETER ANALYSIS OF LABORATORY BIOMARKERS TO ASSESS RHEUMATOID ARTHRITIS ACTIVITY |
| title_short | USE OF MULTIPARAMETER ANALYSIS OF LABORATORY BIOMARKERS TO ASSESS RHEUMATOID ARTHRITIS ACTIVITY |
| title_sort | use of multiparameter analysis of laboratory biomarkers to assess rheumatoid arthritis activity |
| topic | rheumatoid arthritis biomarkers, multiparameter analysis |
| url | https://rsp.mediar-press.net/rsp/article/view/2148 |
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