Effect of Combined Hydroxyurea and Chelation Therapy in Reducing Serum Ferritin Level, Liver and Spleen Size in Transfusion Dependent Thalassaemia Major Patients.
Background: To compare hydroxyurea plus iron chelation therapy with iron chelation therapy alone in controlling iron overload in children with beta thalassaemia major. Methods: In this comparative study forty thalassaemia major, cases undergoing routine blood transfusion, were observed in iron...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Rawalpindi Medical University
2019-05-01
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| Series: | Journal of Rawalpindi Medical College |
| Online Access: | https://www.journalrmc.com/index.php/JRMC/article/view/1088 |
| _version_ | 1818135368205074432 |
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| author | Tatheer Zahra Wajeeha Amber Itrat Fatima |
| author_facet | Tatheer Zahra Wajeeha Amber Itrat Fatima |
| author_sort | Tatheer Zahra |
| collection | DOAJ |
| description | Background: To compare hydroxyurea plus iron
chelation therapy with iron chelation therapy alone
in controlling iron overload in children with beta
thalassaemia major.
Methods: In this comparative study forty
thalassaemia major, cases undergoing routine blood
transfusion, were observed in iron chelation plus
hydroxyurea group (n=20) and iron chelation therapy
alone (n=20). The study outcome was measured in
terms of impact of continuous blood transfusions on
the size of liver ,spleen and Serum. Ferritin levels
when compared among those given iron chelation
therapy with hydroxyurea and those given iron
chelation alone.
Results: Mean age of patients was comparable
among the two groups. Overall, males were slightly
greater in proportion than females (52.5% versus
47.5%). The mean liver size, spleen size and ferritin
levels were significantly low in hydroxyurea group
compared to no hydroxyurea group (p-value, <0.001).
Conclusion: Hydroxyurea plus iron chelation
therapy is better than iron chelation therapy alone in
controlling iron overload in terms of enlargement of
liver, and also limiting iron stores. |
| first_indexed | 2024-12-11T09:23:24Z |
| format | Article |
| id | doaj.art-0c9c77a6b0cc44f99253b0b8f3ba571b |
| institution | Directory Open Access Journal |
| issn | 1683-3562 1683-3570 |
| language | English |
| last_indexed | 2024-12-11T09:23:24Z |
| publishDate | 2019-05-01 |
| publisher | Rawalpindi Medical University |
| record_format | Article |
| series | Journal of Rawalpindi Medical College |
| spelling | doaj.art-0c9c77a6b0cc44f99253b0b8f3ba571b2022-12-22T01:13:12ZengRawalpindi Medical UniversityJournal of Rawalpindi Medical College1683-35621683-35702019-05-01231Effect of Combined Hydroxyurea and Chelation Therapy in Reducing Serum Ferritin Level, Liver and Spleen Size in Transfusion Dependent Thalassaemia Major Patients.Tatheer Zahra0Wajeeha Amber1Itrat Fatima2Bone marrow transplant unit Children hospital PIMS IslamabadDepartment of Paediatrics, Akbar Niazi Hospital, Islamabad Medical and Dental College, IslamabadDepartment of Paediatrics, Children Hospital, Pakistan Institute of Medical Sciences, SZABMU, IslamabadBackground: To compare hydroxyurea plus iron chelation therapy with iron chelation therapy alone in controlling iron overload in children with beta thalassaemia major. Methods: In this comparative study forty thalassaemia major, cases undergoing routine blood transfusion, were observed in iron chelation plus hydroxyurea group (n=20) and iron chelation therapy alone (n=20). The study outcome was measured in terms of impact of continuous blood transfusions on the size of liver ,spleen and Serum. Ferritin levels when compared among those given iron chelation therapy with hydroxyurea and those given iron chelation alone. Results: Mean age of patients was comparable among the two groups. Overall, males were slightly greater in proportion than females (52.5% versus 47.5%). The mean liver size, spleen size and ferritin levels were significantly low in hydroxyurea group compared to no hydroxyurea group (p-value, <0.001). Conclusion: Hydroxyurea plus iron chelation therapy is better than iron chelation therapy alone in controlling iron overload in terms of enlargement of liver, and also limiting iron stores.https://www.journalrmc.com/index.php/JRMC/article/view/1088 |
| spellingShingle | Tatheer Zahra Wajeeha Amber Itrat Fatima Effect of Combined Hydroxyurea and Chelation Therapy in Reducing Serum Ferritin Level, Liver and Spleen Size in Transfusion Dependent Thalassaemia Major Patients. Journal of Rawalpindi Medical College |
| title | Effect of Combined Hydroxyurea and Chelation Therapy in Reducing Serum Ferritin Level, Liver and Spleen Size in Transfusion Dependent Thalassaemia Major Patients. |
| title_full | Effect of Combined Hydroxyurea and Chelation Therapy in Reducing Serum Ferritin Level, Liver and Spleen Size in Transfusion Dependent Thalassaemia Major Patients. |
| title_fullStr | Effect of Combined Hydroxyurea and Chelation Therapy in Reducing Serum Ferritin Level, Liver and Spleen Size in Transfusion Dependent Thalassaemia Major Patients. |
| title_full_unstemmed | Effect of Combined Hydroxyurea and Chelation Therapy in Reducing Serum Ferritin Level, Liver and Spleen Size in Transfusion Dependent Thalassaemia Major Patients. |
| title_short | Effect of Combined Hydroxyurea and Chelation Therapy in Reducing Serum Ferritin Level, Liver and Spleen Size in Transfusion Dependent Thalassaemia Major Patients. |
| title_sort | effect of combined hydroxyurea and chelation therapy in reducing serum ferritin level liver and spleen size in transfusion dependent thalassaemia major patients |
| url | https://www.journalrmc.com/index.php/JRMC/article/view/1088 |
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