NREM sleep stages specifically alter dynamical integration of large-scale brain networks
Summary: Functional dissociations in the brain observed during non-rapid eye movement (NREM) sleep have been associated with reduced information integration and impaired consciousness that accompany increasing sleep depth. Here, we explored the dynamical properties of large-scale functional brain ne...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-01-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004220311202 |
| _version_ | 1831583302435209216 |
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| author | Anjali Tarun Danyal Wainstein-Andriano Virginie Sterpenich Laurence Bayer Lampros Perogamvros Mark Solms Nikolai Axmacher Sophie Schwartz Dimitri Van De Ville |
| author_facet | Anjali Tarun Danyal Wainstein-Andriano Virginie Sterpenich Laurence Bayer Lampros Perogamvros Mark Solms Nikolai Axmacher Sophie Schwartz Dimitri Van De Ville |
| author_sort | Anjali Tarun |
| collection | DOAJ |
| description | Summary: Functional dissociations in the brain observed during non-rapid eye movement (NREM) sleep have been associated with reduced information integration and impaired consciousness that accompany increasing sleep depth. Here, we explored the dynamical properties of large-scale functional brain networks derived from transient brain activity using functional magnetic resonance imaging. Spatial brain maps generally display significant modifications in terms of their tendency to occur across wakefulness and NREM sleep. Unexpectedly, almost all networks predominated in activity during NREM stage 2 before an abrupt loss of activity is observed in NREM stage 3. Yet, functional connectivity and mutual dependencies between these networks progressively broke down with increasing sleep depth. Thus, the efficiency of information transfer during NREM stage 2 is low despite the high attempt to communicate. Critically, our approach provides relevant data for evaluating functional brain network integrity and our findings robustly support a significant advance in our neural models of human sleep and consciousness. |
| first_indexed | 2024-12-17T20:39:51Z |
| format | Article |
| id | doaj.art-0c9cb50f9b7f4cd88daa115dd897b7fa |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-12-17T20:39:51Z |
| publishDate | 2021-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-0c9cb50f9b7f4cd88daa115dd897b7fa2022-12-21T21:33:20ZengElsevieriScience2589-00422021-01-01241101923NREM sleep stages specifically alter dynamical integration of large-scale brain networksAnjali Tarun0Danyal Wainstein-Andriano1Virginie Sterpenich2Laurence Bayer3Lampros Perogamvros4Mark Solms5Nikolai Axmacher6Sophie Schwartz7Dimitri Van De Ville8École Polytechnique Fédérale de Lausanne (Institute of Bioengineering, Medical Image Processing Laboratory), Geneva 1202, Switzerland; University of Geneva (Department of Radiology and Medical Informatics), Geneva 1202, Switzerland; Corresponding authorUniversity of Cape Town (Psychology Department, Faculty of Humanities), Cape Town 7701, South Africa; Ruhr-Universität Bochum (Institute of Cognitive Neuroscience, Faculty of Psychology), Ruhr 44801, GermanyUniversity of Geneva, (Department of Basic Neurosciences), Geneva 1202, SwitzerlandUniversity Hospitals of Geneva (Center for Sleep Medicine, Department of Medicine), Geneva 1202, SwitzerlandUniversity of Geneva, (Department of Basic Neurosciences), Geneva 1202, Switzerland; University Hospitals of Geneva (Center for Sleep Medicine, Department of Medicine), Geneva 1202, SwitzerlandUniversity of Cape Town (Psychology Department, Faculty of Humanities), Cape Town 7701, South AfricaRuhr-Universität Bochum (Institute of Cognitive Neuroscience, Faculty of Psychology), Ruhr 44801, GermanyUniversity of Geneva, (Department of Basic Neurosciences), Geneva 1202, SwitzerlandÉcole Polytechnique Fédérale de Lausanne (Institute of Bioengineering, Medical Image Processing Laboratory), Geneva 1202, Switzerland; University of Geneva (Department of Radiology and Medical Informatics), Geneva 1202, SwitzerlandSummary: Functional dissociations in the brain observed during non-rapid eye movement (NREM) sleep have been associated with reduced information integration and impaired consciousness that accompany increasing sleep depth. Here, we explored the dynamical properties of large-scale functional brain networks derived from transient brain activity using functional magnetic resonance imaging. Spatial brain maps generally display significant modifications in terms of their tendency to occur across wakefulness and NREM sleep. Unexpectedly, almost all networks predominated in activity during NREM stage 2 before an abrupt loss of activity is observed in NREM stage 3. Yet, functional connectivity and mutual dependencies between these networks progressively broke down with increasing sleep depth. Thus, the efficiency of information transfer during NREM stage 2 is low despite the high attempt to communicate. Critically, our approach provides relevant data for evaluating functional brain network integrity and our findings robustly support a significant advance in our neural models of human sleep and consciousness.http://www.sciencedirect.com/science/article/pii/S2589004220311202Medical ImagingSystems NeuroscienceCognitive NeuroscienceTechniques in Neuroscience |
| spellingShingle | Anjali Tarun Danyal Wainstein-Andriano Virginie Sterpenich Laurence Bayer Lampros Perogamvros Mark Solms Nikolai Axmacher Sophie Schwartz Dimitri Van De Ville NREM sleep stages specifically alter dynamical integration of large-scale brain networks iScience Medical Imaging Systems Neuroscience Cognitive Neuroscience Techniques in Neuroscience |
| title | NREM sleep stages specifically alter dynamical integration of large-scale brain networks |
| title_full | NREM sleep stages specifically alter dynamical integration of large-scale brain networks |
| title_fullStr | NREM sleep stages specifically alter dynamical integration of large-scale brain networks |
| title_full_unstemmed | NREM sleep stages specifically alter dynamical integration of large-scale brain networks |
| title_short | NREM sleep stages specifically alter dynamical integration of large-scale brain networks |
| title_sort | nrem sleep stages specifically alter dynamical integration of large scale brain networks |
| topic | Medical Imaging Systems Neuroscience Cognitive Neuroscience Techniques in Neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2589004220311202 |
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