Impaired TIGIT expression on B cells drives circulating follicular helper T cell expansion in multiple sclerosis

Impaired TIGIT expression on B cells drives circulating follicular helper T cell expansion in multiple sclerosis

B cell depletion in patients with relapsing-remitting multiple sclerosis (RRMS) markedly prevents new MRI-detected lesions and disease activity, suggesting the hypothesis that altered B cell function leads to the activation of T cells driving disease pathogenesis. Here, we performed comprehensive an...

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Bibliographic Details
Main Authors: Hiromitsu Asashima, Pierre-Paul Axisa, Thi Hong Giang Pham, Erin E. Longbrake, William E. Ruff, Nikhil Lele, Inessa Cohen, Khadir Raddassi, Tomokazu S. Sumida, David A. Hafler
Format: Article
Language:English
Published: American Society for Clinical Investigation 2022-10-01
Series:The Journal of Clinical Investigation
Subjects:
Autoimmunity
Immunology
Online Access:https://doi.org/10.1172/JCI156254

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