Shape-recovery of implanted shape-memory devices remotely triggered via image-guided ultrasound heating
Abstract Shape-memory materials hold great potential to impart medical devices with functionalities useful during implantation, locomotion, drug delivery, and removal. However, their clinical translation is limited by a lack of non-invasive and precise methods to trigger and control the shape recove...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
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Nature Portfolio
2024-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-45437-2 |
| _version_ | 1797274072766218240 |
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| author | Yang Zhu Kaicheng Deng Jianwei Zhou Chong Lai Zuwei Ma Hua Zhang Jiazhen Pan Liyin Shen Matthew D. Bucknor Eugene Ozhinsky Seungil Kim Guangjie Chen Sang-ho Ye Yue Zhang Donghong Liu Changyou Gao Yonghua Xu Huanan Wang William R. Wagner |
| author_facet | Yang Zhu Kaicheng Deng Jianwei Zhou Chong Lai Zuwei Ma Hua Zhang Jiazhen Pan Liyin Shen Matthew D. Bucknor Eugene Ozhinsky Seungil Kim Guangjie Chen Sang-ho Ye Yue Zhang Donghong Liu Changyou Gao Yonghua Xu Huanan Wang William R. Wagner |
| author_sort | Yang Zhu |
| collection | DOAJ |
| description | Abstract Shape-memory materials hold great potential to impart medical devices with functionalities useful during implantation, locomotion, drug delivery, and removal. However, their clinical translation is limited by a lack of non-invasive and precise methods to trigger and control the shape recovery, especially for devices implanted in deep tissues. In this study, the application of image-guided high-intensity focused ultrasound (HIFU) heating is tested. Magnetic resonance-guided HIFU triggered shape-recovery of a device made of polyurethane urea while monitoring its temperature by magnetic resonance thermometry. Deformation of the polyurethane urea in a live canine bladder (5 cm deep) is achieved with 8 seconds of ultrasound-guided HIFU with millimeter resolution energy focus. Tissue sections show no hyperthermic tissue injury. A conceptual application in ureteral stent shape-recovery reduces removal resistance. In conclusion, image-guided HIFU demonstrates deep energy penetration, safety and speed. |
| first_indexed | 2024-03-07T14:53:09Z |
| format | Article |
| id | doaj.art-0c9e33818a6643c8a8fb954efbea5d61 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-07T14:53:09Z |
| publishDate | 2024-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-0c9e33818a6643c8a8fb954efbea5d612024-03-05T19:32:33ZengNature PortfolioNature Communications2041-17232024-02-0115111210.1038/s41467-024-45437-2Shape-recovery of implanted shape-memory devices remotely triggered via image-guided ultrasound heatingYang Zhu0Kaicheng Deng1Jianwei Zhou2Chong Lai3Zuwei Ma4Hua Zhang5Jiazhen Pan6Liyin Shen7Matthew D. Bucknor8Eugene Ozhinsky9Seungil Kim10Guangjie Chen11Sang-ho Ye12Yue Zhang13Donghong Liu14Changyou Gao15Yonghua Xu16Huanan Wang17William R. Wagner18MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang UniversityMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang UniversitySchool of Electromechanical and Energy Engineering, NingboTech UniversityDepartment of Urology, First Affiliated Hospital, School of Medicine, Zhejiang UniversityMcGowan Institute for Regenerative Medicine, University of PittsburghCollege of Animal Sciences, Zhejiang UniversityCollege of Animal Sciences, Zhejiang UniversityMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang UniversityRadiology and Biomedical Imaging, University of CaliforniaRadiology and Biomedical Imaging, University of CaliforniaMcGowan Institute for Regenerative Medicine, University of PittsburghDepartment of Urology, The Children’s Hospital, School of Medicine, National Clinical Research Center for Child Health, Zhejiang UniversityMcGowan Institute for Regenerative Medicine, University of PittsburghSan Francisco Veterans Affairs Medical Center, University of CaliforniaCollege of Biosystems Engineering and Food Science, National-Local Joint Engineering Laboratory of Intelligent Food Technology and Equipment, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang UniversityMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang UniversityDepartment of Imaging and Interventional Radiology, Zhongshan-Xuhui Hospital of Fudan University/Shanghai Xuhui Central HospitalCollege of Animal Sciences, Zhejiang UniversityMcGowan Institute for Regenerative Medicine, University of PittsburghAbstract Shape-memory materials hold great potential to impart medical devices with functionalities useful during implantation, locomotion, drug delivery, and removal. However, their clinical translation is limited by a lack of non-invasive and precise methods to trigger and control the shape recovery, especially for devices implanted in deep tissues. In this study, the application of image-guided high-intensity focused ultrasound (HIFU) heating is tested. Magnetic resonance-guided HIFU triggered shape-recovery of a device made of polyurethane urea while monitoring its temperature by magnetic resonance thermometry. Deformation of the polyurethane urea in a live canine bladder (5 cm deep) is achieved with 8 seconds of ultrasound-guided HIFU with millimeter resolution energy focus. Tissue sections show no hyperthermic tissue injury. A conceptual application in ureteral stent shape-recovery reduces removal resistance. In conclusion, image-guided HIFU demonstrates deep energy penetration, safety and speed.https://doi.org/10.1038/s41467-024-45437-2 |
| spellingShingle | Yang Zhu Kaicheng Deng Jianwei Zhou Chong Lai Zuwei Ma Hua Zhang Jiazhen Pan Liyin Shen Matthew D. Bucknor Eugene Ozhinsky Seungil Kim Guangjie Chen Sang-ho Ye Yue Zhang Donghong Liu Changyou Gao Yonghua Xu Huanan Wang William R. Wagner Shape-recovery of implanted shape-memory devices remotely triggered via image-guided ultrasound heating Nature Communications |
| title | Shape-recovery of implanted shape-memory devices remotely triggered via image-guided ultrasound heating |
| title_full | Shape-recovery of implanted shape-memory devices remotely triggered via image-guided ultrasound heating |
| title_fullStr | Shape-recovery of implanted shape-memory devices remotely triggered via image-guided ultrasound heating |
| title_full_unstemmed | Shape-recovery of implanted shape-memory devices remotely triggered via image-guided ultrasound heating |
| title_short | Shape-recovery of implanted shape-memory devices remotely triggered via image-guided ultrasound heating |
| title_sort | shape recovery of implanted shape memory devices remotely triggered via image guided ultrasound heating |
| url | https://doi.org/10.1038/s41467-024-45437-2 |
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