Chronic vagus nerve stimulation in patients with heart failure: challenge or failed translation?
Autonomic imbalance between the sympathetic and parasympathetic nervous systems contributes to the progression of chronic heart failure (HF). Preclinical studies have demonstrated that various neuromodulation strategies may exert beneficial cardioprotective effects in preclinical models of HF. Based...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1052471/full |
| _version_ | 1827898822422953984 |
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| author | Zhihong Wu Jiaying Liao Qiming Liu Shenghua Zhou Mingxian Chen |
| author_facet | Zhihong Wu Jiaying Liao Qiming Liu Shenghua Zhou Mingxian Chen |
| author_sort | Zhihong Wu |
| collection | DOAJ |
| description | Autonomic imbalance between the sympathetic and parasympathetic nervous systems contributes to the progression of chronic heart failure (HF). Preclinical studies have demonstrated that various neuromodulation strategies may exert beneficial cardioprotective effects in preclinical models of HF. Based on these encouraging experimental data, vagus nerve stimulation (VNS) has been assessed in patients with HF with a reduced ejection fraction. Nevertheless, the main trials conducted thus far have yielded conflicting findings, questioning the clinical efficacy of VNS in this context. This review will therefore focus on the role of the autonomic nervous system in HF pathophysiology and VNS therapy, highlighting the potential reasons behind the discrepancy between preclinical and clinical studies. |
| first_indexed | 2024-03-12T23:09:15Z |
| format | Article |
| id | doaj.art-0ca1c4505293456eb87198a3576d6d7d |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-03-12T23:09:15Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-0ca1c4505293456eb87198a3576d6d7d2023-07-18T08:07:25ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2023-07-011010.3389/fcvm.2023.10524711052471Chronic vagus nerve stimulation in patients with heart failure: challenge or failed translation?Zhihong Wu0Jiaying Liao1Qiming Liu2Shenghua Zhou3Mingxian Chen4Department of Cardiovascular, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Nephrology, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Cardiovascular, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Cardiovascular, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Cardiovascular, The Second Xiangya Hospital of Central South University, Changsha, ChinaAutonomic imbalance between the sympathetic and parasympathetic nervous systems contributes to the progression of chronic heart failure (HF). Preclinical studies have demonstrated that various neuromodulation strategies may exert beneficial cardioprotective effects in preclinical models of HF. Based on these encouraging experimental data, vagus nerve stimulation (VNS) has been assessed in patients with HF with a reduced ejection fraction. Nevertheless, the main trials conducted thus far have yielded conflicting findings, questioning the clinical efficacy of VNS in this context. This review will therefore focus on the role of the autonomic nervous system in HF pathophysiology and VNS therapy, highlighting the potential reasons behind the discrepancy between preclinical and clinical studies.https://www.frontiersin.org/articles/10.3389/fcvm.2023.1052471/fullvagus nerve stimulationheart failureanti-inflammatorytragus nerve stimulationtranslation |
| spellingShingle | Zhihong Wu Jiaying Liao Qiming Liu Shenghua Zhou Mingxian Chen Chronic vagus nerve stimulation in patients with heart failure: challenge or failed translation? Frontiers in Cardiovascular Medicine vagus nerve stimulation heart failure anti-inflammatory tragus nerve stimulation translation |
| title | Chronic vagus nerve stimulation in patients with heart failure: challenge or failed translation? |
| title_full | Chronic vagus nerve stimulation in patients with heart failure: challenge or failed translation? |
| title_fullStr | Chronic vagus nerve stimulation in patients with heart failure: challenge or failed translation? |
| title_full_unstemmed | Chronic vagus nerve stimulation in patients with heart failure: challenge or failed translation? |
| title_short | Chronic vagus nerve stimulation in patients with heart failure: challenge or failed translation? |
| title_sort | chronic vagus nerve stimulation in patients with heart failure challenge or failed translation |
| topic | vagus nerve stimulation heart failure anti-inflammatory tragus nerve stimulation translation |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1052471/full |
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