A Novel Aminomethacrylate-Based Copolymer for Solubility Enhancement—From Radical Polymer Synthesis to Manufacture and Characterization of Amorphous Solid Dispersions

A Novel Aminomethacrylate-Based Copolymer for Solubility Enhancement—From Radical Polymer Synthesis to Manufacture and Characterization of Amorphous Solid Dispersions

The present study covers the synthesis, purification and evaluation of a novel aminomethacrylate-based copolymer in terms of its suitability for improving the solubility and in vitro release of poorly water-soluble drug compounds. The new copolymer was synthesized by solvent polymerization with radi...

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Bibliographic Details
Main Authors:	Fabian-Pascal Schmied, Alexander Bernhardt, Christian Moers, Christian Meier, Thomas Endres, Sandra Klein
Format:	Article
Language:	English
Published:	MDPI AG 2022-03-01
Series:	Polymers
Subjects:	drug release molecular weight glass transition poorly soluble drugs in vitro dissolution hot melt extrusion
Online Access:	https://www.mdpi.com/2073-4360/14/7/1281

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