7-Chloroquinolinehydrazones as First-in-Class Anticancer Experimental Drugs in the NCI-60 Screen among Different Investigated Series of Aryl, Quinoline, Pyridine, Benzothiazole and Imidazolehydrazones
In the context of a continuously increasing global cancer risk, the search for new effective and affordable anticancer drugs remains a constant demand. This study describes chemical experimental drugs able to destroy cancer cells by arresting their growth. New hydrazones with quinoline, pyridine, be...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/16/5/691 |
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| author | Georgiana Negru (Apostol) Alina Ghinet Elena Bîcu |
| author_facet | Georgiana Negru (Apostol) Alina Ghinet Elena Bîcu |
| author_sort | Georgiana Negru (Apostol) |
| collection | DOAJ |
| description | In the context of a continuously increasing global cancer risk, the search for new effective and affordable anticancer drugs remains a constant demand. This study describes chemical experimental drugs able to destroy cancer cells by arresting their growth. New hydrazones with quinoline, pyridine, benzothiazole and imidazole moieties have been synthesized and evaluated for their cytotoxic potential against 60 cancer cell lines. 7-Chloroquinolinehydrazones were the most active in the current study and exhibited good cytotoxic activity with submicromolar GI<sub>50</sub> values on a large panel of cell lines from nine tumor types (leukemia, non-small cell lung cancer, colon cancer, CNS cancer, melanoma, ovarian cancer, renal cancer, prostate cancer and breast cancer). This study provided consistent structure-activity relationships in this series of experimental antitumor compounds. |
| first_indexed | 2024-03-11T03:25:01Z |
| format | Article |
| id | doaj.art-0ca38055239c4c698bd5f1c5fc37f304 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-11T03:25:01Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-0ca38055239c4c698bd5f1c5fc37f3042023-11-18T02:48:33ZengMDPI AGPharmaceuticals1424-82472023-05-0116569110.3390/ph160506917-Chloroquinolinehydrazones as First-in-Class Anticancer Experimental Drugs in the NCI-60 Screen among Different Investigated Series of Aryl, Quinoline, Pyridine, Benzothiazole and ImidazolehydrazonesGeorgiana Negru (Apostol)0Alina Ghinet1Elena Bîcu2Faculty of Chemistry, ‘Alexandru Ioan Cuza’ University of Iasi, Bd. Carol I, nr. 11, 700506 Iasi, RomaniaFaculty of Chemistry, ‘Alexandru Ioan Cuza’ University of Iasi, Bd. Carol I, nr. 11, 700506 Iasi, RomaniaFaculty of Chemistry, ‘Alexandru Ioan Cuza’ University of Iasi, Bd. Carol I, nr. 11, 700506 Iasi, RomaniaIn the context of a continuously increasing global cancer risk, the search for new effective and affordable anticancer drugs remains a constant demand. This study describes chemical experimental drugs able to destroy cancer cells by arresting their growth. New hydrazones with quinoline, pyridine, benzothiazole and imidazole moieties have been synthesized and evaluated for their cytotoxic potential against 60 cancer cell lines. 7-Chloroquinolinehydrazones were the most active in the current study and exhibited good cytotoxic activity with submicromolar GI<sub>50</sub> values on a large panel of cell lines from nine tumor types (leukemia, non-small cell lung cancer, colon cancer, CNS cancer, melanoma, ovarian cancer, renal cancer, prostate cancer and breast cancer). This study provided consistent structure-activity relationships in this series of experimental antitumor compounds.https://www.mdpi.com/1424-8247/16/5/691hydrazone7-chloroquinolineNCI panelantitumorpharmacomodulationSAR |
| spellingShingle | Georgiana Negru (Apostol) Alina Ghinet Elena Bîcu 7-Chloroquinolinehydrazones as First-in-Class Anticancer Experimental Drugs in the NCI-60 Screen among Different Investigated Series of Aryl, Quinoline, Pyridine, Benzothiazole and Imidazolehydrazones Pharmaceuticals hydrazone 7-chloroquinoline NCI panel antitumor pharmacomodulation SAR |
| title | 7-Chloroquinolinehydrazones as First-in-Class Anticancer Experimental Drugs in the NCI-60 Screen among Different Investigated Series of Aryl, Quinoline, Pyridine, Benzothiazole and Imidazolehydrazones |
| title_full | 7-Chloroquinolinehydrazones as First-in-Class Anticancer Experimental Drugs in the NCI-60 Screen among Different Investigated Series of Aryl, Quinoline, Pyridine, Benzothiazole and Imidazolehydrazones |
| title_fullStr | 7-Chloroquinolinehydrazones as First-in-Class Anticancer Experimental Drugs in the NCI-60 Screen among Different Investigated Series of Aryl, Quinoline, Pyridine, Benzothiazole and Imidazolehydrazones |
| title_full_unstemmed | 7-Chloroquinolinehydrazones as First-in-Class Anticancer Experimental Drugs in the NCI-60 Screen among Different Investigated Series of Aryl, Quinoline, Pyridine, Benzothiazole and Imidazolehydrazones |
| title_short | 7-Chloroquinolinehydrazones as First-in-Class Anticancer Experimental Drugs in the NCI-60 Screen among Different Investigated Series of Aryl, Quinoline, Pyridine, Benzothiazole and Imidazolehydrazones |
| title_sort | 7 chloroquinolinehydrazones as first in class anticancer experimental drugs in the nci 60 screen among different investigated series of aryl quinoline pyridine benzothiazole and imidazolehydrazones |
| topic | hydrazone 7-chloroquinoline NCI panel antitumor pharmacomodulation SAR |
| url | https://www.mdpi.com/1424-8247/16/5/691 |
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