Blood type, ABO genetic variants, and ovarian cancer survival.
Blood type A and the A1 allele have been associated with increased ovarian cancer risk. With only two small studies published to date, evidence for an association between ABO blood type and ovarian cancer survival is limited.We conducted a retrospective cohort study of Tumor Registry confirmed ovari...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5407760?pdf=render |
| _version_ | 1818854942524309504 |
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| author | Gabriella D Cozzi Rebecca T Levinson Hilary Toole Malcolm-Robert Snyder Angie Deng Marta A Crispens Dineo Khabele Alicia Beeghly-Fadiel |
| author_facet | Gabriella D Cozzi Rebecca T Levinson Hilary Toole Malcolm-Robert Snyder Angie Deng Marta A Crispens Dineo Khabele Alicia Beeghly-Fadiel |
| author_sort | Gabriella D Cozzi |
| collection | DOAJ |
| description | Blood type A and the A1 allele have been associated with increased ovarian cancer risk. With only two small studies published to date, evidence for an association between ABO blood type and ovarian cancer survival is limited.We conducted a retrospective cohort study of Tumor Registry confirmed ovarian cancer cases from the Vanderbilt University Medical Center with blood type from linked laboratory reports and ABO variants from linked Illumina Exome BeadChip data. Associations with overall survival (OS) were quantified by hazard ratios (HR) and confidence intervals (CI) from proportional hazards regression models; covariates included age, race, stage, grade, histologic subtype, and year of diagnosis.ABO phenotype (N = 694) and/or genotype (N = 154) data were available for 713 predominantly Caucasian (89.3%) cases. In multivariable models, blood type A had significantly better OS compared to either O (HR: 0.75, 95% CI: 0.60-0.93) or all non-A (HR: 0.77, 95% CI: 0.63-0.94) cases. Similarly, missense rs1053878 minor allele carriers (A2) had better OS (HR: 0.50, 95% CI: 0.25-0.99). Among Caucasians, this phenotype association was strengthened, but the genotype association was attenuated; instead, four variants sharing moderate linkage disequilibrium with the O variant were associated with better OS (HR: 0.62, 95% CI: 0.39-0.99) in unadjusted models.Blood type A was significantly associated with longer ovarian cancer survival in the largest such study to date. This finding was supported by genetic analysis, which implicated the A2 allele, although O related variants also had suggestive associations. Further research on ABO and ovarian cancer survival is warranted. |
| first_indexed | 2024-12-19T08:00:43Z |
| format | Article |
| id | doaj.art-0ca3f37cc6f74b5eaba23aa8fe4bdd46 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-19T08:00:43Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-0ca3f37cc6f74b5eaba23aa8fe4bdd462022-12-21T20:29:52ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01124e017511910.1371/journal.pone.0175119Blood type, ABO genetic variants, and ovarian cancer survival.Gabriella D CozziRebecca T LevinsonHilary TooleMalcolm-Robert SnyderAngie DengMarta A CrispensDineo KhabeleAlicia Beeghly-FadielBlood type A and the A1 allele have been associated with increased ovarian cancer risk. With only two small studies published to date, evidence for an association between ABO blood type and ovarian cancer survival is limited.We conducted a retrospective cohort study of Tumor Registry confirmed ovarian cancer cases from the Vanderbilt University Medical Center with blood type from linked laboratory reports and ABO variants from linked Illumina Exome BeadChip data. Associations with overall survival (OS) were quantified by hazard ratios (HR) and confidence intervals (CI) from proportional hazards regression models; covariates included age, race, stage, grade, histologic subtype, and year of diagnosis.ABO phenotype (N = 694) and/or genotype (N = 154) data were available for 713 predominantly Caucasian (89.3%) cases. In multivariable models, blood type A had significantly better OS compared to either O (HR: 0.75, 95% CI: 0.60-0.93) or all non-A (HR: 0.77, 95% CI: 0.63-0.94) cases. Similarly, missense rs1053878 minor allele carriers (A2) had better OS (HR: 0.50, 95% CI: 0.25-0.99). Among Caucasians, this phenotype association was strengthened, but the genotype association was attenuated; instead, four variants sharing moderate linkage disequilibrium with the O variant were associated with better OS (HR: 0.62, 95% CI: 0.39-0.99) in unadjusted models.Blood type A was significantly associated with longer ovarian cancer survival in the largest such study to date. This finding was supported by genetic analysis, which implicated the A2 allele, although O related variants also had suggestive associations. Further research on ABO and ovarian cancer survival is warranted.http://europepmc.org/articles/PMC5407760?pdf=render |
| spellingShingle | Gabriella D Cozzi Rebecca T Levinson Hilary Toole Malcolm-Robert Snyder Angie Deng Marta A Crispens Dineo Khabele Alicia Beeghly-Fadiel Blood type, ABO genetic variants, and ovarian cancer survival. PLoS ONE |
| title | Blood type, ABO genetic variants, and ovarian cancer survival. |
| title_full | Blood type, ABO genetic variants, and ovarian cancer survival. |
| title_fullStr | Blood type, ABO genetic variants, and ovarian cancer survival. |
| title_full_unstemmed | Blood type, ABO genetic variants, and ovarian cancer survival. |
| title_short | Blood type, ABO genetic variants, and ovarian cancer survival. |
| title_sort | blood type abo genetic variants and ovarian cancer survival |
| url | http://europepmc.org/articles/PMC5407760?pdf=render |
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