Genomic rearrangements and functional diversification of lecA and lecB lectin-coding regions impacting the efficacy of glycomimetics directed against Pseudomonas aeruginosa

Genomic rearrangements and functional diversification of lecA and lecB lectin-coding regions impacting the efficacy of glycomimetics directed against Pseudomonas aeruginosa

LecA and LecB tetrameric lectins take part in oligosaccharide-mediated adhesion-processes of Pseudomonas aeruginosa. Glycomimetics have been designed to block these interactions. The great versatility of P. aeruginosa suggests that the range of application of these glycomimetics could be restricted...

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Bibliographic Details
Main Authors: Amine M Boukerb, Aude eDecor, Sebastien eRibun, Rachel eTabaroni, Audric eRousset, Loris eCommin, Samuel eBuff, Anne eDoleans-Jordheim, Sebastien eVidal, Annabelle eVarrot, Anne eImberty, Benoit eCournoyer
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-05-01
Series:Frontiers in Microbiology
Subjects:
Flow Cytometry
Pseudomonas aeruginosa
glycan array
Glycoclusters
Crystallography.
soluble lectins
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.00811/full

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