Cerebrospinal fluid metabolite alterations in patients with different etiologies, diagnoses, and prognoses of disorders of consciousness
Abstract Introduction Medical management of disorders of consciousness (DoC) is a growing issue imposing a major burden on families and societies. Recovery rates vary widely among patients with DoC, and recovery predictions strongly influence decisions on medical care. However, the specific mechanis...
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| Format: | Article |
| Language: | English |
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Wiley
2023-08-01
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| Series: | Brain and Behavior |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/brb3.3070 |
| _version_ | 1797359458187214848 |
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| author | Long Xu Qianqian Ge Hezhen Lu Yutong Zhuang Xiaoli Geng Xueling Chen Xiaoyan Liu Haidan Sun Zhengguang Guo Jiameng Sun Feng Qi Xia Niu Aiwei Wang Wei Sun Jianghong He |
| author_facet | Long Xu Qianqian Ge Hezhen Lu Yutong Zhuang Xiaoli Geng Xueling Chen Xiaoyan Liu Haidan Sun Zhengguang Guo Jiameng Sun Feng Qi Xia Niu Aiwei Wang Wei Sun Jianghong He |
| author_sort | Long Xu |
| collection | DOAJ |
| description | Abstract Introduction Medical management of disorders of consciousness (DoC) is a growing issue imposing a major burden on families and societies. Recovery rates vary widely among patients with DoC, and recovery predictions strongly influence decisions on medical care. However, the specific mechanisms underlying different etiologies, consciousness levels, and prognoses are still unclear. Methods We analyzed the comprehensive cerebrospinal fluid (CSF) metabolome through liquid chromatography‐mass spectrometry. Metabolomic analyses were used to identify the metabolic differences between patients with different etiologies, diagnoses, and prognoses. Results We found that the CSF levels of multiple acylcarnitines were lower in patients with traumatic DoC, suggesting mitochondrial function preservation in the CNS, which might contribute to the better consciousness outcomes of these patients. Metabolites related to glutamate and GABA metabolism were altered and showed a good ability to distinguish the patients in the minimally conscious state and the vegetative state. Moreover, we identified 8 phospholipids as potential biomarkers to predict the recovery of consciousness. Conclusions Our findings shed light on the differences in physiological activities underlying DoC with different etiologies and identified some potential biomarkers used for DoC diagnosis and prognosis. |
| first_indexed | 2024-03-08T15:25:09Z |
| format | Article |
| id | doaj.art-0ca61c440695404781de7ddd89b06220 |
| institution | Directory Open Access Journal |
| issn | 2162-3279 |
| language | English |
| last_indexed | 2024-03-08T15:25:09Z |
| publishDate | 2023-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj.art-0ca61c440695404781de7ddd89b062202024-01-10T10:25:35ZengWileyBrain and Behavior2162-32792023-08-01138n/an/a10.1002/brb3.3070Cerebrospinal fluid metabolite alterations in patients with different etiologies, diagnoses, and prognoses of disorders of consciousnessLong Xu0Qianqian Ge1Hezhen Lu2Yutong Zhuang3Xiaoli Geng4Xueling Chen5Xiaoyan Liu6Haidan Sun7Zhengguang Guo8Jiameng Sun9Feng Qi10Xia Niu11Aiwei Wang12Wei Sun13Jianghong He14Department of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing ChinaDepartment of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing ChinaDepartment of clinical laboratoryChina‐Japan Union Hospital of Jilin UniversityChangchunChinaDepartment of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing ChinaDepartment of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing ChinaDepartment of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing ChinaCore Instrument Facility, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College Beijing ChinaCore Instrument Facility, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College Beijing ChinaCore Instrument Facility, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College Beijing ChinaCore Instrument Facility, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College Beijing ChinaCore Instrument Facility, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College Beijing ChinaCore Instrument Facility, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College Beijing ChinaCore Instrument Facility, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College Beijing ChinaCore Instrument Facility, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College Beijing ChinaDepartment of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing ChinaAbstract Introduction Medical management of disorders of consciousness (DoC) is a growing issue imposing a major burden on families and societies. Recovery rates vary widely among patients with DoC, and recovery predictions strongly influence decisions on medical care. However, the specific mechanisms underlying different etiologies, consciousness levels, and prognoses are still unclear. Methods We analyzed the comprehensive cerebrospinal fluid (CSF) metabolome through liquid chromatography‐mass spectrometry. Metabolomic analyses were used to identify the metabolic differences between patients with different etiologies, diagnoses, and prognoses. Results We found that the CSF levels of multiple acylcarnitines were lower in patients with traumatic DoC, suggesting mitochondrial function preservation in the CNS, which might contribute to the better consciousness outcomes of these patients. Metabolites related to glutamate and GABA metabolism were altered and showed a good ability to distinguish the patients in the minimally conscious state and the vegetative state. Moreover, we identified 8 phospholipids as potential biomarkers to predict the recovery of consciousness. Conclusions Our findings shed light on the differences in physiological activities underlying DoC with different etiologies and identified some potential biomarkers used for DoC diagnosis and prognosis.https://doi.org/10.1002/brb3.3070biomarkerscerebrospinal fluidconsciousness disordersmetabolomics |
| spellingShingle | Long Xu Qianqian Ge Hezhen Lu Yutong Zhuang Xiaoli Geng Xueling Chen Xiaoyan Liu Haidan Sun Zhengguang Guo Jiameng Sun Feng Qi Xia Niu Aiwei Wang Wei Sun Jianghong He Cerebrospinal fluid metabolite alterations in patients with different etiologies, diagnoses, and prognoses of disorders of consciousness Brain and Behavior biomarkers cerebrospinal fluid consciousness disorders metabolomics |
| title | Cerebrospinal fluid metabolite alterations in patients with different etiologies, diagnoses, and prognoses of disorders of consciousness |
| title_full | Cerebrospinal fluid metabolite alterations in patients with different etiologies, diagnoses, and prognoses of disorders of consciousness |
| title_fullStr | Cerebrospinal fluid metabolite alterations in patients with different etiologies, diagnoses, and prognoses of disorders of consciousness |
| title_full_unstemmed | Cerebrospinal fluid metabolite alterations in patients with different etiologies, diagnoses, and prognoses of disorders of consciousness |
| title_short | Cerebrospinal fluid metabolite alterations in patients with different etiologies, diagnoses, and prognoses of disorders of consciousness |
| title_sort | cerebrospinal fluid metabolite alterations in patients with different etiologies diagnoses and prognoses of disorders of consciousness |
| topic | biomarkers cerebrospinal fluid consciousness disorders metabolomics |
| url | https://doi.org/10.1002/brb3.3070 |
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