Efficacy of pure olive oil and PRF in the prevention of postoperative peritoneal adhesions
Purpose: In this study, we applied platelet rich fibrin (PRF) and pure olive oil on the incision surfaces of rats. We aimed to examine whether PRF may be used safely to prevent peritoneal adhesions. Materials and Methods: Fourty rats were divided into 4 groups (n=8). Eight rats, not included in the...
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| Format: | Article |
| Language: | English |
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Cukurova University
2022-06-01
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| Series: | Cukurova Medical Journal |
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| Online Access: | https://dergipark.org.tr/tr/download/article-file/2111062 |
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| author | Ahmet Gökhan Güler Ali Erdal Karakaya Abdulkadir Yasir Bahar Muhammed Seyithanoğlu Duygun Altıntaş Aykan Dilan Altıntaş Ural |
| author_facet | Ahmet Gökhan Güler Ali Erdal Karakaya Abdulkadir Yasir Bahar Muhammed Seyithanoğlu Duygun Altıntaş Aykan Dilan Altıntaş Ural |
| author_sort | Ahmet Gökhan Güler |
| collection | DOAJ |
| description | Purpose: In this study, we applied platelet rich fibrin (PRF) and pure olive oil on the incision surfaces of rats. We aimed to examine whether PRF may be used safely to prevent peritoneal adhesions.
Materials and Methods: Fourty rats were divided into 4 groups (n=8). Eight rats, not included in the study groups, were used to obtain PRF material. Group 1 had no surgical procedure, Group 2 was operated without medication, Group 3 was operated and received 1cc olive oil, Group 4 was operated and received 1 cc PRF. After 21 days, cecum areas were examined histopathologically. Tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), intercellular adhesion molecule-1 (ICAM-1) and platelet-derived growth factor (PDGF) levels were measured in serum by ELISA.
Results: The adhesion scores and severity of fibrosis in Group 3 and 4 were significantly lower than Group 2. Plasma TNF-α value was significantly higher in Group 2 than Group 4. Plasma PDGF value was significantly higher in Group 2 than Group 3 and 4.
Discussion: PRF reduced intestinal adhesion by inhibiting the proliferation of fibroblasts and inflammatory cells, and promoting the proliferation of mesothelial cells. PRF has anti-inflammatory effect and prevented postop adhesions, based mainly on growth factors and cytokines in its content. |
| first_indexed | 2024-04-10T10:59:29Z |
| format | Article |
| id | doaj.art-0ca61f8900f2455f8be4bbddda75f98c |
| institution | Directory Open Access Journal |
| issn | 2602-3040 |
| language | English |
| last_indexed | 2024-04-10T10:59:29Z |
| publishDate | 2022-06-01 |
| publisher | Cukurova University |
| record_format | Article |
| series | Cukurova Medical Journal |
| spelling | doaj.art-0ca61f8900f2455f8be4bbddda75f98c2023-02-15T16:19:45ZengCukurova UniversityCukurova Medical Journal2602-30402022-06-0147257057910.17826/cumj.103138848Efficacy of pure olive oil and PRF in the prevention of postoperative peritoneal adhesionsAhmet Gökhan Güler0Ali Erdal Karakaya1Abdulkadir Yasir Bahar2Muhammed Seyithanoğlu3Duygun Altıntaş Aykan4Dilan Altıntaş Ural5KAHRAMANMARAŞ SÜTÇÜ İMAM ÜNİVERSİTESİKAHRAMANMARAŞ SÜTÇÜ İMAM ÜNİVERSİTESİ, TIP FAKÜLTESİKAHRAMANMARAŞ SÜTÇÜ İMAM ÜNİVERSİTESİ, TIP FAKÜLTESİKAHRAMANMARAS SUTCU IMAM UNIVERSITYKAHRAMANMARAŞ SÜTÇÜ İMAM ÜNİVERSİTESİ, TIP FAKÜLTESİMemorial Ankara HastanesiPurpose: In this study, we applied platelet rich fibrin (PRF) and pure olive oil on the incision surfaces of rats. We aimed to examine whether PRF may be used safely to prevent peritoneal adhesions. Materials and Methods: Fourty rats were divided into 4 groups (n=8). Eight rats, not included in the study groups, were used to obtain PRF material. Group 1 had no surgical procedure, Group 2 was operated without medication, Group 3 was operated and received 1cc olive oil, Group 4 was operated and received 1 cc PRF. After 21 days, cecum areas were examined histopathologically. Tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), intercellular adhesion molecule-1 (ICAM-1) and platelet-derived growth factor (PDGF) levels were measured in serum by ELISA. Results: The adhesion scores and severity of fibrosis in Group 3 and 4 were significantly lower than Group 2. Plasma TNF-α value was significantly higher in Group 2 than Group 4. Plasma PDGF value was significantly higher in Group 2 than Group 3 and 4. Discussion: PRF reduced intestinal adhesion by inhibiting the proliferation of fibroblasts and inflammatory cells, and promoting the proliferation of mesothelial cells. PRF has anti-inflammatory effect and prevented postop adhesions, based mainly on growth factors and cytokines in its content.https://dergipark.org.tr/tr/download/article-file/2111062postoperatıve perıtoneal adhesıonsplatelet rich fibrinpure olive oilpostoperatıve perıtoneal adhesıonsplatelet rich fibrinpure olive oil |
| spellingShingle | Ahmet Gökhan Güler Ali Erdal Karakaya Abdulkadir Yasir Bahar Muhammed Seyithanoğlu Duygun Altıntaş Aykan Dilan Altıntaş Ural Efficacy of pure olive oil and PRF in the prevention of postoperative peritoneal adhesions Cukurova Medical Journal postoperatıve perıtoneal adhesıons platelet rich fibrin pure olive oil postoperatıve perıtoneal adhesıons platelet rich fibrin pure olive oil |
| title | Efficacy of pure olive oil and PRF in the prevention of postoperative peritoneal adhesions |
| title_full | Efficacy of pure olive oil and PRF in the prevention of postoperative peritoneal adhesions |
| title_fullStr | Efficacy of pure olive oil and PRF in the prevention of postoperative peritoneal adhesions |
| title_full_unstemmed | Efficacy of pure olive oil and PRF in the prevention of postoperative peritoneal adhesions |
| title_short | Efficacy of pure olive oil and PRF in the prevention of postoperative peritoneal adhesions |
| title_sort | efficacy of pure olive oil and prf in the prevention of postoperative peritoneal adhesions |
| topic | postoperatıve perıtoneal adhesıons platelet rich fibrin pure olive oil postoperatıve perıtoneal adhesıons platelet rich fibrin pure olive oil |
| url | https://dergipark.org.tr/tr/download/article-file/2111062 |
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