Are Steroid Hormones Dysregulated in Autistic Girls?
Evidence of altered cholesterol and steroid hormones in autism is increasing. However, as boys are more often affected, evidence mainly relates to autistic males, whereas evidence for affected autistic girls is sparse. Therefore, a comprehensive gas chromatography mass spectrometry-based steroid hor...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-03-01
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| Series: | Diseases |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-9721/8/1/6 |
| _version_ | 1818772011041685504 |
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| author | Benedikt Andreas Gasser Johann Kurz Bernhard Dick Markus Georg Mohaupt |
| author_facet | Benedikt Andreas Gasser Johann Kurz Bernhard Dick Markus Georg Mohaupt |
| author_sort | Benedikt Andreas Gasser |
| collection | DOAJ |
| description | Evidence of altered cholesterol and steroid hormones in autism is increasing. However, as boys are more often affected, evidence mainly relates to autistic males, whereas evidence for affected autistic girls is sparse. Therefore, a comprehensive gas chromatography mass spectrometry-based steroid hormone metabolite analysis was conducted from autistic girls. Results show increased levels of several steroid hormones, especially in the class of androgens in autistic girls such as testosterone or androstenediol. The increase of the majority of steroid hormones in autistic girls is probably best explained multifactorially by a higher substrate provision in line with the previously developed cholesterol hypothesis of autism. |
| first_indexed | 2024-12-18T10:02:34Z |
| format | Article |
| id | doaj.art-0ca62a7182fd49b9b572cd0f926d36f3 |
| institution | Directory Open Access Journal |
| issn | 2079-9721 |
| language | English |
| last_indexed | 2024-12-18T10:02:34Z |
| publishDate | 2020-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diseases |
| spelling | doaj.art-0ca62a7182fd49b9b572cd0f926d36f32022-12-21T21:11:37ZengMDPI AGDiseases2079-97212020-03-0181610.3390/diseases8010006diseases8010006Are Steroid Hormones Dysregulated in Autistic Girls?Benedikt Andreas Gasser0Johann Kurz1Bernhard Dick2Markus Georg Mohaupt3Department of Clinical Research, University of Bern, 3010 Berne, SwitzerlandTeaching Hospital Internal Medicine, Lindenhofgruppe, 3006 Berne, SwitzerlandDepartment of Clinical Research, University of Bern, 3010 Berne, SwitzerlandTeaching Hospital Internal Medicine, Lindenhofgruppe, 3006 Berne, SwitzerlandEvidence of altered cholesterol and steroid hormones in autism is increasing. However, as boys are more often affected, evidence mainly relates to autistic males, whereas evidence for affected autistic girls is sparse. Therefore, a comprehensive gas chromatography mass spectrometry-based steroid hormone metabolite analysis was conducted from autistic girls. Results show increased levels of several steroid hormones, especially in the class of androgens in autistic girls such as testosterone or androstenediol. The increase of the majority of steroid hormones in autistic girls is probably best explained multifactorially by a higher substrate provision in line with the previously developed cholesterol hypothesis of autism.https://www.mdpi.com/2079-9721/8/1/6gas chromatography-mass spectrometrycholesterol21-hydroxylase |
| spellingShingle | Benedikt Andreas Gasser Johann Kurz Bernhard Dick Markus Georg Mohaupt Are Steroid Hormones Dysregulated in Autistic Girls? Diseases gas chromatography-mass spectrometry cholesterol 21-hydroxylase |
| title | Are Steroid Hormones Dysregulated in Autistic Girls? |
| title_full | Are Steroid Hormones Dysregulated in Autistic Girls? |
| title_fullStr | Are Steroid Hormones Dysregulated in Autistic Girls? |
| title_full_unstemmed | Are Steroid Hormones Dysregulated in Autistic Girls? |
| title_short | Are Steroid Hormones Dysregulated in Autistic Girls? |
| title_sort | are steroid hormones dysregulated in autistic girls |
| topic | gas chromatography-mass spectrometry cholesterol 21-hydroxylase |
| url | https://www.mdpi.com/2079-9721/8/1/6 |
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