Autonomic functions in hypothyroidism
Background: Hypothyroidism is a common endocrine disorder in the general population. Most of the cardiovascular and neurological manifestations of hypothyroidism are due to autonomic dysfunction. The American Academy of Neurology has recommended simple bedside autonomic function tests for the diagno...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Journal of Indian College of Cardiology |
| Subjects: | |
| Online Access: | http://www.joicc.org/article.asp?issn=1561-8811;year=2023;volume=13;issue=1;spage=23;epage=28;aulast=Jose |
| _version_ | 1797321539817832448 |
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| author | Antony Jose Roshan Maroli Peter George |
| author_facet | Antony Jose Roshan Maroli Peter George |
| author_sort | Antony Jose |
| collection | DOAJ |
| description | Background: Hypothyroidism is a common endocrine disorder in the general population. Most of the cardiovascular and neurological manifestations of hypothyroidism are due to autonomic dysfunction. The American Academy of Neurology has recommended simple bedside autonomic function tests for the diagnosis and follow-up of autonomic functions. Recognition of autonomic dysfunction and treatment of hypothyroidism may improve cardiovascular outcomes. This study aims to assess autonomic dysfunction in hypothyroidism and correlate it with serum thyroid-stimulating hormone (TSH) levels. Materials and Methods: This cross-sectional study was conducted on 60 patients diagnosed with hypothyroidism for 12 months at a tertiary care center in Southern India. Patients with a Zulewski clinical score over 5 and fulfilling the selection criteria were included in the study after obtaining written informed consent. Details of history, treatment, examination, and thyroid function tests data were collected and bedside tests for autonomic functions were performed. Results: Ninety percent of individuals were female, and the average age of the included study population was 40.38 ± 11.78 years. Based on TSH and FT4 values, the patients were subgrouped into currently euthyroid and overt hypothyroid individuals. The majority of the individuals (81.67%) included in the study had autonomic dysfunction. Based on the autonomic dysfunction score, there was a significantly higher proportion of overt hypothyroid individuals (n = 18) with severe autonomic dysfunction compared to euthyroid individuals (n = 4). About 75% of the study individuals had sympathetic dysfunction and 66.7% of individuals had parasympathetic dysfunction. There was no statistically significant association between autonomic dysfunction and the duration of hypothyroidism. Conclusion: Autonomic dysfunction in hypothyroidism is common; sympathetic dysfunction was observed more as compared to parasympathetic dysfunction. |
| first_indexed | 2024-03-08T05:00:02Z |
| format | Article |
| id | doaj.art-0ca67ebe5694452398d31a509f7901d7 |
| institution | Directory Open Access Journal |
| issn | 1561-8811 2213-3615 |
| language | English |
| last_indexed | 2024-03-08T05:00:02Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Indian College of Cardiology |
| spelling | doaj.art-0ca67ebe5694452398d31a509f7901d72024-02-07T12:48:21ZengWolters Kluwer Medknow PublicationsJournal of Indian College of Cardiology1561-88112213-36152023-01-01131232810.4103/jicc.jicc_15_22Autonomic functions in hypothyroidismAntony JoseRoshan MaroliPeter GeorgeBackground: Hypothyroidism is a common endocrine disorder in the general population. Most of the cardiovascular and neurological manifestations of hypothyroidism are due to autonomic dysfunction. The American Academy of Neurology has recommended simple bedside autonomic function tests for the diagnosis and follow-up of autonomic functions. Recognition of autonomic dysfunction and treatment of hypothyroidism may improve cardiovascular outcomes. This study aims to assess autonomic dysfunction in hypothyroidism and correlate it with serum thyroid-stimulating hormone (TSH) levels. Materials and Methods: This cross-sectional study was conducted on 60 patients diagnosed with hypothyroidism for 12 months at a tertiary care center in Southern India. Patients with a Zulewski clinical score over 5 and fulfilling the selection criteria were included in the study after obtaining written informed consent. Details of history, treatment, examination, and thyroid function tests data were collected and bedside tests for autonomic functions were performed. Results: Ninety percent of individuals were female, and the average age of the included study population was 40.38 ± 11.78 years. Based on TSH and FT4 values, the patients were subgrouped into currently euthyroid and overt hypothyroid individuals. The majority of the individuals (81.67%) included in the study had autonomic dysfunction. Based on the autonomic dysfunction score, there was a significantly higher proportion of overt hypothyroid individuals (n = 18) with severe autonomic dysfunction compared to euthyroid individuals (n = 4). About 75% of the study individuals had sympathetic dysfunction and 66.7% of individuals had parasympathetic dysfunction. There was no statistically significant association between autonomic dysfunction and the duration of hypothyroidism. Conclusion: Autonomic dysfunction in hypothyroidism is common; sympathetic dysfunction was observed more as compared to parasympathetic dysfunction.http://www.joicc.org/article.asp?issn=1561-8811;year=2023;volume=13;issue=1;spage=23;epage=28;aulast=Joseautonomic dysfunctionheart rate response to standingheart response to deep breathinghypothyroidismpostural challenge testsustained hand grip testthyroid function testsvalsalva ratio |
| spellingShingle | Antony Jose Roshan Maroli Peter George Autonomic functions in hypothyroidism Journal of Indian College of Cardiology autonomic dysfunction heart rate response to standing heart response to deep breathing hypothyroidism postural challenge test sustained hand grip test thyroid function tests valsalva ratio |
| title | Autonomic functions in hypothyroidism |
| title_full | Autonomic functions in hypothyroidism |
| title_fullStr | Autonomic functions in hypothyroidism |
| title_full_unstemmed | Autonomic functions in hypothyroidism |
| title_short | Autonomic functions in hypothyroidism |
| title_sort | autonomic functions in hypothyroidism |
| topic | autonomic dysfunction heart rate response to standing heart response to deep breathing hypothyroidism postural challenge test sustained hand grip test thyroid function tests valsalva ratio |
| url | http://www.joicc.org/article.asp?issn=1561-8811;year=2023;volume=13;issue=1;spage=23;epage=28;aulast=Jose |
| work_keys_str_mv | AT antonyjose autonomicfunctionsinhypothyroidism AT roshanmaroli autonomicfunctionsinhypothyroidism AT petergeorge autonomicfunctionsinhypothyroidism |