Genetic associations between autoimmune diseases and the risks of severe sepsis and 28-day mortality: a two-sample Mendelian randomization study

Genetic associations between autoimmune diseases and the risks of severe sepsis and 28-day mortality: a two-sample Mendelian randomization study

BackgroundAutoimmune diseases exhibit heterogenous dysregulation of pro-inflammatory or anti-inflammatory cytokine expression, akin to the pathophysiology of sepsis. It is speculated that individuals with autoimmune diseases may have an increased likelihood of developing sepsis and face elevated mor...

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Bibliographic Details
Main Authors: Xin Tie, Yanjie Zhao, Jing Su, Xing Liu, Tongjuan Zou, Wanhong Yin
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Medicine
Subjects:
sepsis
autoimmune diseases
Mendelian randomization
28-day mortality
risk factor
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2024.1331950/full

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