Potential Beneficial Effects of Dietary Protein Supplementation and Exercise on Functional Capacity in a Pilot Study of Individuals with Heart Failure with Preserved Ejection Fraction
Approximately half of heart failure patients in the US have heart failure with preserved ejection fraction (HFpEF). HFpEF impairs physical performance and thus reduces quality of life. Increasing dietary protein intake can increase lean body mass and physical performance in healthy elderly individua...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2020-12-01
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| Series: | Gerontology and Geriatric Medicine |
| Online Access: | https://doi.org/10.1177/2333721420982808 |
| _version_ | 1828892012194037760 |
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| author | Gohar Azhar Sakeena Raza Amanda Pangle Kellie Coleman Amanda Dawson Amy Schrader Robert R. Wolfe Jeanne Y. Wei |
| author_facet | Gohar Azhar Sakeena Raza Amanda Pangle Kellie Coleman Amanda Dawson Amy Schrader Robert R. Wolfe Jeanne Y. Wei |
| author_sort | Gohar Azhar |
| collection | DOAJ |
| description | Approximately half of heart failure patients in the US have heart failure with preserved ejection fraction (HFpEF). HFpEF impairs physical performance and thus reduces quality of life. Increasing dietary protein intake can increase lean body mass and physical performance in healthy elderly individuals, but the effect of a high-quality protein supplement, with or without a structured exercise program, has not been investigated in HFpEF patients. Twenty-three obese elderly HFpEF patients with grade 1 or 2 diastolic dysfunction were randomized into three groups: control, protein supplementation alone, and protein plus exercise. Protein supplementation involved providing sufficient whey protein so that total intake was 1.2 g protein/kg/day. The exercise intervention was 2 days of hydrotherapy and 1 day of gym sessions per week under supervision of a fitness expert. Physical parameters and functional tests were performed at baseline and at 12 weeks. Protein supplementation alone failed to improve physical performance. However, when combined with light exercise, there was significant improvement in some (6-minute walk, 10 m walking speed, quadriceps strength), but not all, physical function measurements. The results of this pilot study suggest that further exploration of potential interactive effects between protein supplementation and light exercise in individuals with HFpEF is warranted. |
| first_indexed | 2024-12-13T13:27:10Z |
| format | Article |
| id | doaj.art-0caa3bf9c764490e862def35fdd29f61 |
| institution | Directory Open Access Journal |
| issn | 2333-7214 |
| language | English |
| last_indexed | 2024-12-13T13:27:10Z |
| publishDate | 2020-12-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Gerontology and Geriatric Medicine |
| spelling | doaj.art-0caa3bf9c764490e862def35fdd29f612022-12-21T23:44:15ZengSAGE PublishingGerontology and Geriatric Medicine2333-72142020-12-01610.1177/2333721420982808Potential Beneficial Effects of Dietary Protein Supplementation and Exercise on Functional Capacity in a Pilot Study of Individuals with Heart Failure with Preserved Ejection FractionGohar Azhar0Sakeena Raza1Amanda Pangle2Kellie Coleman3Amanda Dawson4Amy Schrader5Robert R. Wolfe6Jeanne Y. Wei7Donald W. Reynolds Institute on Aging, UAMS, Little Rock, AR, USADonald W. Reynolds Institute on Aging, UAMS, Little Rock, AR, USADonald W. Reynolds Institute on Aging, UAMS, Little Rock, AR, USADonald W. Reynolds Institute on Aging, UAMS, Little Rock, AR, USADonald W. Reynolds Institute on Aging, UAMS, Little Rock, AR, USADonald W. Reynolds Institute on Aging, UAMS, Little Rock, AR, USADonald W. Reynolds Institute on Aging, UAMS, Little Rock, AR, USADonald W. Reynolds Institute on Aging, UAMS, Little Rock, AR, USAApproximately half of heart failure patients in the US have heart failure with preserved ejection fraction (HFpEF). HFpEF impairs physical performance and thus reduces quality of life. Increasing dietary protein intake can increase lean body mass and physical performance in healthy elderly individuals, but the effect of a high-quality protein supplement, with or without a structured exercise program, has not been investigated in HFpEF patients. Twenty-three obese elderly HFpEF patients with grade 1 or 2 diastolic dysfunction were randomized into three groups: control, protein supplementation alone, and protein plus exercise. Protein supplementation involved providing sufficient whey protein so that total intake was 1.2 g protein/kg/day. The exercise intervention was 2 days of hydrotherapy and 1 day of gym sessions per week under supervision of a fitness expert. Physical parameters and functional tests were performed at baseline and at 12 weeks. Protein supplementation alone failed to improve physical performance. However, when combined with light exercise, there was significant improvement in some (6-minute walk, 10 m walking speed, quadriceps strength), but not all, physical function measurements. The results of this pilot study suggest that further exploration of potential interactive effects between protein supplementation and light exercise in individuals with HFpEF is warranted.https://doi.org/10.1177/2333721420982808 |
| spellingShingle | Gohar Azhar Sakeena Raza Amanda Pangle Kellie Coleman Amanda Dawson Amy Schrader Robert R. Wolfe Jeanne Y. Wei Potential Beneficial Effects of Dietary Protein Supplementation and Exercise on Functional Capacity in a Pilot Study of Individuals with Heart Failure with Preserved Ejection Fraction Gerontology and Geriatric Medicine |
| title | Potential Beneficial Effects of Dietary Protein Supplementation and Exercise on Functional Capacity in a Pilot Study of Individuals with Heart Failure with Preserved Ejection Fraction |
| title_full | Potential Beneficial Effects of Dietary Protein Supplementation and Exercise on Functional Capacity in a Pilot Study of Individuals with Heart Failure with Preserved Ejection Fraction |
| title_fullStr | Potential Beneficial Effects of Dietary Protein Supplementation and Exercise on Functional Capacity in a Pilot Study of Individuals with Heart Failure with Preserved Ejection Fraction |
| title_full_unstemmed | Potential Beneficial Effects of Dietary Protein Supplementation and Exercise on Functional Capacity in a Pilot Study of Individuals with Heart Failure with Preserved Ejection Fraction |
| title_short | Potential Beneficial Effects of Dietary Protein Supplementation and Exercise on Functional Capacity in a Pilot Study of Individuals with Heart Failure with Preserved Ejection Fraction |
| title_sort | potential beneficial effects of dietary protein supplementation and exercise on functional capacity in a pilot study of individuals with heart failure with preserved ejection fraction |
| url | https://doi.org/10.1177/2333721420982808 |
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